Decreased proliferation ability and differentiation potential of mesenchymal stem cells of osteoporosis rat.

Abstract:

OBJECTIVE:To explore decreased proliferation ability and differentiation potential of mesenchymal stem cells (MSCs) of osteoporosis rat. METHODS:MSCs were obtained from osteoporosis rat, and proliferation potency and impaired osteogenic differentiation potential were determined. RESULTS:The result showed a significant downregulation of MSCs pluripotency related gene (Oct 4) and osteogenic genes (BSP, OCN) expression in OVX MSCs compared with Sham MSCs (P<0.05). CONCLUSIONS:These data suggest that MSCs are aging in osteoporosis body, and autologous OVX MSCs transplantation is not appropriate to treat osteoporosis if necessary. There will be a possibility in establishing a new clinical application of MSCs autologous transplantation to treat osteoporosis, if OVX MSCs have stronger proliferation and differentiation.

journal_name

Asian Pac J Trop Med

authors

Wang Q,Zhao B,Li C,Rong JS,Tao SQ,Tao TZ

doi

10.1016/S1995-7645(14)60055-9

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

358-63

issue

5

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(14)60055-9

journal_volume

7

pub_type

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