Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats.

Abstract:

OBJECTIVE:To observe the protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats. METHODS:All rats were randomly divided into normal control group, cirrhosis and treatment group. Thioacetamide was used to establish rat model of cirrhotic portal hypertension. The necrotic tissue of gastric mucosa ulcer focus, degree of neutrophils infiltration at the ulcer margin, portal pressure, portal venous flow, abdominal aortic pressure, abdominal aortic blood flow at front end, gastric mucosal blood flow (GMBF), glycoprotein (GP) of gastric mucosa, basal acid secretion, H(+)back -diffusion, gastric mucosal damage index, NO, prostaglandin E2(PGE2) and tumor necrosis factor-α (TNF-α) were determined respectively, and the pathological changes of gastric mucosa were also observed by microscope. RESULTS:Compared with cirrhosis group and the control group, the ulcer bottom necrotic material, gastric neutrophil infiltration and UI of the treatment group were all decreased significantly (P<0.01), GMBF value, GP values, serum NO, PGE2, TNF-α were all significantly increased. CONCLUSIONS:Omeprazole has an important protective effect on gastric mucosal and it can increase gastric mucosal blood flow and related to many factors.

journal_name

Asian Pac J Trop Med

authors

Gao W,Li HY,Wang LX,Hao LJ,Gao JL,Zheng RJ,Cai CJ,Si YL

doi

10.1016/S1995-7645(14)60065-1

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

402-6

issue

5

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(14)60065-1

journal_volume

7

pub_type

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