Antiviral activity of maca (Lepidium meyenii) against human influenza virus.

Abstract:

OBJECTIVE:To investigate antiviral activity of maca to reduce viral load in Madin-Darby canine kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and Flu-B, respectively). METHODS:Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the extracts were evaluated on MDCK cells using method MTT assay. Antiviral activity of compounds against Flu-A and Flu-B viruses was assayed using a test for determining the inhibition of the cytopathic effect on cell culture and multiplex RT-PCR. RESULTS:The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC50] of 157.4 and 110.5, respectively. CONCLUSIONS:In vitro assays demonstrated that maca has antiviral activity not only against Flu-A (like most antiviral agents) but also Flu-B viruses, providing remarkable therapeutic benefits.

journal_name

Asian Pac J Trop Med

authors

Del Valle Mendoza J,Pumarola T,Gonzales LA,Del Valle LJ

doi

10.1016/S1995-7645(14)60268-6

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

S415-20

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(14)60268-6

journal_volume

7S1

pub_type

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