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Comparison of hypotensive, diuretic and renal effects between cladodes of Opuntia ficus-indica and furosemide.

Abstract：

OBJECTIVE:To investigate the diuretic, hypotensive and renal effect of Opuntia ficus-indica in two different species in oral and intravenous administration. METHODS:Diuretic activity was evaluated in rats with the plant cladode gel and aqueous extract administrated orally, and was evaluated in rabbits with plant extract administered intravenously. Single and repeated doses of cladode gel or aqueous extract of cladode were tested. Urine volume and blood and urine creatinine, sodium and potassium were measured, and creatinine clearance was calculated. The hypotensive effect of lyophilized extract of cladode was evaluated in rabbits. Two polyethylene PE50 catheters were used: one in the jugular vein for the infusion of the plant extract and the other in the carotid for the evaluation of the arterial pressure. RESULTS:The cladode gel or aqueous extract increased urine volume, creatinine clearance and urinary excretion of sodium and potassium without significant effect on serum creatinine or blood urea. Furosemide, gel and aqueous extract of cladode insignificantly lowered plasma potassium in rats. Intravenous administration of the lyophilized extract caused a significant decrease in mean arterial pressure in rabbits with a significant increase in urine volume and urine sodium and potassium; the effect was dose dependent. Intravenous administration of lyophilized extract did not affect plasma sodium or potassium. CONCLUSIONS:Gel and aqueous extract of Opuntia ficus-indica cladode have a significant diuretic effect on rats, and the lyophilized extract has a diuretic and hypotensive effect on normotensive rabbits without deterioration in renal function test. Additional studies on active ingredients are essential to pave the way for clinical studies on diuretic and hypotensive effect of the plant.

journal_name

Asian Pac J Trop Med

journal_title

Asian Pacific journal of tropical medicine

authors

Bakour M,Al-Waili N,El-Haskoury R,El-Menyiy N,Al-Waili T,Al-Waili A,Lyoussi B

doi

10.1016/j.apjtm.2017.08.016

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

900-906

issue

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(17)30930-6

journal_volume

pub_type

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Comparison of hypotensive, diuretic and renal effects between cladodes of Opuntia ficus-indica and furosemide.