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Cortisol and uncomplicated Plasmodium falciparum malaria in an area of unstable malaria transmission in eastern Sudan.

Abstract：

OBJECTIVE:To investigate the levels of serum cortisol in patients with uncomplicated Plasmodium falciparum (P. falciparum) malaria in an area of unstable malaria transmission in eastern Sudan. METHODS:The concentrations of cortisol were measured in sera of 25 patients with uncomplicated P. falciparum malaria (at presentation, 24 h and 7 d later) and 25 healthy volunteers using radioimmunoassay gamma counter. RESULTS:There was no significant difference in mean (SD) of total cortisol levels in patients with malaria in comparison with the control group; 602.2 (369.6) vs. 449.2(311.7) ng/mL, P=0.12. In patients with uncomplicated P. falciparum malaria, the mean (SD) presenting cortisol levels were significantly higher in comparison to the levels on day 7; 602.2 (369.6) vs. 373.6(139.1) ng/mL, P=0.009. In the patients with uncomplicated P. falciparum malaria (on presentation) cortisol levels were not correlated with initial temperature or the presenting parasitaemia. CONCLUSIONS:Thus, cortisol levels were not significantly different between the patients and the controls.

journal_name

Asian Pac J Trop Med

journal_title

Asian Pacific journal of tropical medicine

authors

Ibrahim EA,Kheir MM,Elhardello OA,Almahi WA,Ali NI,Elbashir MI,Ishag A

doi

10.1016/S1995-7645(11)60056-4

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

146-7

issue

2

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(11)60056-4

journal_volume

4

pub_type

杂志文章

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