当前位置： SCI文献检索 > Asian Pacific Journal of Tropical Medicine期刊下所有文献 > Content determination of benzyl glucosinolate and anti-cancer activity of its hydrolysis product in Carica papaya L.

Content determination of benzyl glucosinolate and anti-cancer activity of its hydrolysis product in Carica papaya L.

Abstract：

OBJECTIVE:To determine the content of benzyl glucosinolate (BG) in the pulp and the seed and investigate the anti-cancer activity of its hydrolysis product in Carica papaya L. METHODS:Determination of BG was performed on an Hypersil BDS C(18) column at the wavelength of 214 nm with 0.1% trifluoroacetic acid (TFA) aqueous solution (A) and 0.1%TFA acetonitrile (B) as the mobile phase. In vitro activity test was adopted with cultured human lung cancer H69 cell in vitro to investigate the inhibition rate of cell proliferation of benzyl isothiocyanate (BITC) against H69 cell. RESULTS:The pulp has more BG before the maturation of papaya and it nearly disappeared after papaya matured, while the seed contains BG at every stage. Activity test demonstrated that the a higher concentration of BITC would have better inhibition rate of cell proliferation on H69 cell, and the IC(50) was 6.5 μmol/L. CONCLUSIONS:BG also can be produced in the pulp of papaya and it will be stored in the seed after the fruit has been matured. The hydrolysis product of BG has certain cancer-prevention anti-cancer activities for human.

journal_name

Asian Pac J Trop Med

journal_title

Asian Pacific journal of tropical medicine

authors

Li ZY,Wang Y,Shen WT,Zhou P

doi

10.1016/S1995-7645(12)60030-3

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

231-3

issue

3

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(12)60030-3

journal_volume

5

pub_type

杂志文章

相关文献

Asian Pacific Journal of Tropical Medicine文献大全
  • Profile and geographical distribution of reported cutaneous leishmaniasis cases in Northwestern Saudi Arabia, from 2010 to 2013.

    abstract：OBJECTIVE:To describe the profile and geographical distribution of reported cases of cutaneous leishmaniasis (CL) in the province of Hail, Saudi Arabia from 2010 to 2013. METHODS:Human data were collected from the dermatology service of both King Khaled and General Hail hospitals. RESULTS:A total of 483 confirmed CL ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60332-1

    authors： Haouas N,Amer O,Ishankyty A,Alazmi A,Ishankyty I

    更新日期：2015-04-01 00:00:00

  • Pharmacological evaluation of smooth muscle relaxant and cardiac-modulation potential of Phyla nodiflora in ex-vivo and in-vivo experiments.

    abstract：OBJECTIVE:To investigate the pharmacological basis of its uses of Phyla nodiflora (P. nodiflora) for the treatment of anomalies predominantly by smooth muscle containing tissues such as gastrointestinal/vascular/broncho spasm and cardiovascular modulation. METHODS:The crude hydroalcoholic extract of P. nodiflora (Pn.C...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2017.10.021

    authors： Abdur Rahman HM,Ahmed K,Rasool MF,Imran I

    更新日期：2017-12-01 00:00:00

  • In vitro inhibitory effects of plumbagin, the promising antimalarial candidate, on human cytochrome P450 enzymes.

    abstract：OBJECTIVE:To investigate the propensity of plumbagin to inhibit the three isoforms of human cytochrome P450 (CYP), i.e., CYP1A2, CYP2C19, and CYP3A4 using human liver microsomes in vitro. METHODS:Inhibitory effects of plumbagin on the three human CYP isoforms were investigated using pooled human liver microsomes. Phen...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2015.10.016

    authors： Sumsakul W,Chaijaroenkul W,Na-Bangchang K

    更新日期：2015-11-01 00:00:00

  • Helianthus tuberosus (Jerusalem artichoke) tubers improve glucose tolerance and hepatic lipid profile in rats fed a high-fat diet.

    abstract：OBJECTIVES:To analyze the effects of feeding Helianthus tuberosus (HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet (HFD). METHODS:A normal HFD or HFD including 10 w/w% HT tubers (HFD + HT) was fed to F334/Jcl rats. After 10 weeks, organ weights, glucose tolerance, and lipid profile were a...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2017.03.028

    authors： Okada N,Kobayashi S,Moriyama K,Miyataka K,Abe S,Sato C,Kawazoe K

    更新日期：2017-05-01 00:00:00

  • A comparative in vitro antioxidant potential profile of extracts from different parts of Fagonia cretica.

    abstract：OBJECTIVE:To evaluate antioxidant and radical scavenging activities of organic extracts from fruit, roots and aerial parts of Fagonia cretica. METHODS:Shed dried and powdered plant parts were initially extracted in methanol and subsequently partitioned in n-hexane, chloroform, ethyl acetate and 1-butanol successively....

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60277-7

    authors： Iqbal P,Ahmed D,Asghar MN

    更新日期：2014-09-01 00:00:00

  • Effect of recombinant human bone morphogenetic protein 2/poly-lactide-co-glycolic acid (rhBMP-2/PLGA) with core decompression on repair of rabbit femoral head necrosis.

    abstract：OBJECTIVE:To observe the effect of recombinant human bone morphogenetic protein 2/poly-lactide-co-glycolic acid (rhBMP-2/PLGA) with core decompression on repair of rabbit femoral head necrosis. METHOD:Bilateral femoral head necrosis models of rabbit were established by steroid injection. A total of 48 rabbits (96 femo...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60156-5

    authors： Pan ZX,Zhang HX,Wang YX,Zhai LD,Du W

    更新日期：2014-11-01 00:00:00

  • Escherichia coli tetracycline efflux determinants in relation to tetracycline residues in chicken.

    abstract：OBJECTIVE:To screen for Escherichia coli (E. coli) resistant to tetracycline, followed by identification of tet efflux genes by polymerase chain reaction (PCR). In addition, detection of tetracycline residues in chicken livers and kidneys were conducted using high performance liquid chromatography-tandem quadrupole mas...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(13)60125-X

    authors： S N AB,B M AM,A S AA,A E E,I Y M

    更新日期：2013-09-01 00:00:00

  • Antidiabetic activity of aqueous root extract of Merremia tridentata (L.) Hall. f. in streptozotocin-induced-diabetic rats.

    abstract：OBJECTIVE:To investigate the antidiabetic effect of aqueous extract of Merremia tridentata (M. tridentata) root (MTRAE) in normal, glucose-loaded hyperglycemic and streptozotocin (STZ)-induced diabetic rats. METHODS:Oral administration of MTRAE at the doses of 50, 100 and 150 mg/kg was studied in normal, glucose-loade...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60020-0

    authors： Arunachalam K,Parimelazhagan T

    更新日期：2012-03-01 00:00:00

  • Antibacterial activity of selected ethnomedicinal plants from South India.

    abstract：OBJECTIVE:To screen the antimicrobial potential of three ethnomedicinal plants Chassalia curviflora Thw. (C. curviflora), Cyclea peltata Hook. F. & Thomson (C. peltata) and Euphorbia hirta L (E. hirta) used in folk medicines in Aarukani hills Kani tribe, Tamil Nadu, India against human bacterial pathogens. METHODS:Ant...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60107-7

    authors： Raja RD,Jeeva S,Prakash JW,Antonisamy JM,Irudayaraj V

    更新日期：2011-05-01 00:00:00

  • Immunomodulatory effect of garlic oil extract on Schistosoma mansoni infected mice.

    abstract：OBJECTIVE:To assess the effect potency, and the immunomodulatory response of garlic oil extract in enhancing the host's immune system against the disorders caused by Schistosoma mansoni (S. mansoni) in mice at different stages of worm maturation. METHODS:A total of 70 male CD-1 Swiss albino mice were divided into 7 gr...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2015.11.016

    authors： Kamel ROA,El-Shinnawy NA

    更新日期：2015-12-01 00:00:00

  • Anti-encystment and amoebicidal activity of Lonicera japonica Thunb. and its major constituent chlorogenic acid in vitro.

    abstract：OBJECTIVE:To examine the acanthamoebicidal effects of ethyl acetate, aqueous and butanol fractions of dried flower buds of Lonicera japonica (L. japonica) Thunb. (Flos Lonicerae) in vitro. METHODS:Acanthamoeba triangularis isolates were obtained from environmental water samples and identified by PCR. They were exposed...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2016.07.008

    authors： Mahboob T,Azlan AM,Tan TC,Samudi C,Sekaran SD,Nissapatorn V,Wiart C

    更新日期：2016-09-01 00:00:00

  • Prevalence of shiga toxins (stx1, stx2), eaeA and hly genes of Escherichia coli O157:H7 strains among children with acute gastroenteritis in southern of Iran.

    abstract：OBJECTIVE:To survey the prevalence severe diarrhea arising from these bacteria in children under 5 years old in Marvdasht. METHODS:In this study faecal sample from 615 children aged <5 years old who were hospitalized for gastroenteritis in Fars hospitals in Iran were collected and then enriched in Escherichia coli (E....

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60182-6

    authors： Kargar M,Homayoon M

    更新日期：2015-01-01 00:00:00

  • Antioxidant, anti-inflammatory and antinociceptive potential of Ternstroemia sylvatica Schltdl. & Cham.

    abstract：OBJECTIVE:To evaluate the anti-inflammatory, analgesic, antioxidant and acute toxicity of extracts obtained from a successive extraction with solvents of ascending polarity [hexane, hex; chloroform, CHCl3 and ethanol (EtOH)] of Ternstroemia sylvatica Schltdl. & Cham. METHODS:The antioxidant potential was evaluated by ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2017.10.007

    authors： Moreno-Quirós CV,Sánchez-Medina A,Vázquez-Hernández M,Hernández Reyes AG,García-Rodríguez RV

    更新日期：2017-11-01 00:00:00

  • Toxoplasmosis and anti-Toxoplasma effects of medicinal plant extracts-A mini-review.

    abstract：:Toxoplasmosis is a globally distributed parasitic protozoan disease, caused by Toxoplasma gondii. The infection can result in more severe symptoms with potentially life-threatening in case of immunocompromised individuals. Sulfadiazine and pyrimethamine are the two drugs used as a part of standard therapy for toxoplas...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.apjtm.2016.06.012

    authors： Al Nasr I,Ahmed F,Pullishery F,El-Ashram S,Ramaiah VV

    更新日期：2016-08-01 00:00:00

  • RETRACTED: Effect of transplantation of BMMSCs on pathological change of gastric precancerous lesions of rats.

    abstract：OBJECTIVE:To build the rat model of gastric precancerous lesions and discuss the effect of transplantation of mesenchymal stem cells (BMMSCs) on the pathological change. METHODS:The rat model of gastric precancerous lesions was built using N-methyl-N'-nitro-N'-nitrosoguanidine. After the intravenous transplantation of...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章,撤回出版物

    doi：10.1016/j.apjtm.2015.11.006

    authors： Lin ZL,Zheng GW,Zhang L,Zheng JT,Chen H

    更新日期：2015-12-01 00:00:00

  • Immunomodulatory activity of a lupane triterpenoid ester isolated from the eastern Nigeria mistletoe, Loranthus micranthus (Linn).

    abstract：OBJECTIVE:To provide further evidence for the ethnomedicinal use of the Eastern Nigeria mistletoe, Loranthus micranthus (L. micranthus), as an immunostimulant. METHODS:Solvent fractions from the crude extract of the mistletoe plant was obtained and screened by the cell mediated delayed type hypersensitivity reaction (...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60137-5

    authors： Ogechukwu OE,Ogoamaka OP,Sylvester NC,Kawamura A,Proksch P

    更新日期：2011-07-01 00:00:00

  • A case of advanced mycosis fungoides with comprehensive skin and visceral organs metastasis: sensitive to chemical and biological therapy.

    abstract：:Mycosis fungoides is a common cutaneous T-cell lymphoma, which is usually characterized by chronic, indolence progression, with absence of typical symptoms in early stage, metastasis to lymph nodes, bone marrow and visceral organs in later stage and ultimately progression to systemic lymphoma. It can result in seconda...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60138-2

    authors： Liu YQ,Zhu WY,Shu YQ,Gu YH

    更新日期：2012-08-01 00:00:00

  • Anti-hyperglycemic activity of leaves extract of Hyptis suaveolens L. Poit in streptozotocin induced diabetic rats.

    abstract：OBJECTIVE:To evaluate the antihyperglycemic activity of leaves of Hyptis suaveolens using streptozotocin model. METHODS:Hyptis suaveolens extract (HSE) 250 and 500 mg/kg body weight was administered orally to streptozotocin induced diabetes, once daily for 21 days. RESULTS:A significant reduction in blood glucose was...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60175-2

    authors： Mishra SB,Verma A,Mukerjee A,Vijayakumar M

    更新日期：2011-09-01 00:00:00

  • Enhancing effect of ultrasound-mediated microbubble destruction on gene delivery into rat kidney via different administration routes.

    abstract：OBJECTIVE:To investigate the efficiency of β-galactosidase gene transfer into rat kidney with ultrasound-mediated microbubble destruction via different injection routes. METHODS:A total of 25 Wistar rats were randomly divided into 5 groups. Four groups received a mixture of optison microbubbles (0.2 mL) and lacz plasm...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60099-6

    authors： Chen JX,Ma Q,Wu H,Zhou A,Chen X,Peng YM,Liu FY,Cheng MC

    更新日期：2012-07-01 00:00:00

  • Matrine inhibits bladder cancer cell growth and invasion in vitro through PI3K/AKT signaling pathway: An experimental study.

    abstract：OBJECTIVE:To study the inhibitory effect of matrine on bladder cancer cell growth and invasion in vitro through PI3K/AKT signaling pathway. METHODS:Human T24 bladder cancer cell lines were cultured and treated with different doses of matrine (0.25 mg/mL, 0.5 mg/mL and 1.0 mg/mL) as well as 20 μmol/L PI3K inhibitor LY2...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2017.05.009

    authors： Yang Y,Guo JX,Shao ZQ,Gao JP

    更新日期：2017-05-01 00:00:00

  • Antihaemolytic and snake venom neutralizing effect of some Indian medicinal plants.

    abstract：OBJECTIVE:To validate traditional claims of usefulness of the Indian plants in management of poisonous snakebite and evaluate the antivenom properties displayed by the alcoholic extracts of Andrographis paniculata (A. paniculata), Crateva magna (C. magna), Gloriosa superba (G. superba) and Hydrocotyle javanica (H. java...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60185-5

    authors： Kumarapppan C,Jaswanth A,Kumarasunderi K

    更新日期：2011-09-01 00:00:00

  • Immunoprophylactic potential of filarial glutathione-s-transferase in lymphatic filariaisis.

    abstract：OBJECTIVE:To elucidates the immunoprophylactic potential of glutathion-s-transferase (GST) from cattle filarial parasite Setaria digitata (S. digitata) against lymphatic filariasis. METHODS:GST was purified through affinity chromatography (SdGST) and chacterized by SDS-PAGE and Nano-LC MS/MS analysis. Antibody isotype...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60066-7

    authors： Bal M,Mandal N,Achary KG,Das MK,Kar SK

    更新日期：2011-03-01 00:00:00

  • Effect of Chinese herbal compound on liver fibrosis in rabbits with schistosomiasis by B-ultrasound.

    abstract：OBJECTIVE:To explore the value of B-ultrasound on the evaluation of the effects of traditional Chinese medicine compound of Radix astragali, Salvia miltiorrhiza and Angelica sinensis, and TCM + praziquantel on liver fibrosis in rabbits with schistosomiasis. METHODS:The hepatic fibrosis model in rabbits with schistosom...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(13)60114-5

    authors： Liang XL,Yuan JY

    更新日期：2013-08-01 00:00:00

  • Application of TruScreen in detecting ASCUS patients.

    abstract：OBJECTIVE:To explore the application of cervical cancer screening system, TruScreen in detecting atypical squamous cell of undetermined significance (ASCUS) patients. METHODS:A total of 42 cases were selected, who were diagnosed as ASCUS by thinprep cytologic test (TCT). Area from site 15 to 20, site 21 to 32 were det...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60170-3

    authors： Li W,Guo Y,Niu H,Jin S,Wang L

    更新日期：2011-08-01 00:00:00

  • Decreased proliferation ability and differentiation potential of mesenchymal stem cells of osteoporosis rat.

    abstract：OBJECTIVE:To explore decreased proliferation ability and differentiation potential of mesenchymal stem cells (MSCs) of osteoporosis rat. METHODS:MSCs were obtained from osteoporosis rat, and proliferation potency and impaired osteogenic differentiation potential were determined. RESULTS:The result showed a significan...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60055-9

    authors： Wang Q,Zhao B,Li C,Rong JS,Tao SQ,Tao TZ

    更新日期：2014-05-01 00:00:00

  • Antidiarrheal activity of Pterocarpus erinaceus methanol leaf extract in experimentally-induced diarrhea.

    abstract：OBJECTIVE:To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo. METHODS:The methanol leaf extract of Pterocarpus erinaceus was evaluated using different doses (100, 200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea, cha...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60014-5

    authors： Ezeja IM,Ezeigbo II,Madubuike KG,Udeh NE,Ukweni IA,Akomas SC,Ifenkwe DC

    更新日期：2012-02-01 00:00:00

  • bla(CTX-M), bla(TEM), and bla(SHV) in Enterobacteriaceae from North-Indian tertiary hospital: high occurrence of combination genes.

    abstract：OBJECTIVE:To delineate the frequency of occurrence of bla(CTX-M), bla(TEM), and bla(SHV) in Enterobacteriaceae from North-Indian tertiary hospital. METHODS:A random collection of a subset of 45 Escherichia coli (E. coli) and 28 Klebsiella pneumoniae (K. pneumoniae) that was resistant to a third generation cephalospori...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60046-1

    authors： Shahid M,Singh A,Sobia F,Rashid M,Malik A,Shukla I,Khan HM

    更新日期：2011-02-01 00:00:00

  • Demonstration of malaria situation analysis, stratification and planning in Minab District, southern Iran.

    abstract：OBJECTIVE:To demonstrate malaria situation analysis, stratification and planning for an endemic area in southern Iran. METHODS:Data on health system, population, meteorological parameters, malaria cases, anopheline vectors, and control activities during 2005-2007 was obtained from Minab Health Center, Minab Meteorolog...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60036-9

    authors： Hassan V,Arash R,Mehdi J,Ahmad R,Ali HB,Wali YA,Ali D,Abdulrasool M,Abbas P

    更新日期：2011-01-01 00:00:00

  • Evaluation of anti-tubercular activity of linolenic acid and conjugated-linoleic acid as effective inhibitors against Mycobacterium tuberculosis.

    abstract：OBJECTIVE:To evaluate a new pharmacological activity/effect of linolenic acid (α- and γ-form) and conjugated-linoleic acid (CLA) causing antibacterial activity against Mycobacterium tuberculosis (Mtb). METHODS:The anti-Mtb activity/effect of linolenic acid and CLA were determined using different anti-Mtb indicator met...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2016.01.021

    authors： Choi WH

    更新日期：2016-02-01 00:00:00

  • Isolation and characterization of anti-diabetic component (bioactivity-guided fractionation) from Ocimum sanctum L. (Lamiaceae) aerial part.

    abstract：OBJECTIVE:To isolate and characterize antidiabetic component (bioactivity-guided fractionation) from hydro alcoholic extract of Ocimum sanctum (O. sanctum) aerial part. METHODS:Ten fractions (F1-F10) were isolated from hydro alcoholic extract of O. sanctum aerial part by column chromatography. All the fractions F1 to ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60086-2

    authors： Patil R,Patil R,Ahirwar B,Ahirwar D

    更新日期：2011-04-01 00:00:00