Abstract：
OBJECTIVE:To evaluate antioxidant and radical scavenging activities of organic extracts from fruit, roots and aerial parts of Fagonia cretica. METHODS:Shed dried and powdered plant parts were initially extracted in methanol and subsequently partitioned in n-hexane, chloroform, ethyl acetate and 1-butanol successively. Antioxidant and radical scavenging potential of the methanol extracts and the fractions of each part were evaluated using total phenolic contents (TPC) and total flavonoid contents (TFC), 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation radicals scavenging, reducing power (potassium ferricyanide-trichloroacetic acid system), ferric ion reducing antioxidant potential, lipid peroxidation inhibition activity (linoleic acid system) and total antioxidant activity (phosphomolybdate) assays. RESULTS:TPC and TFC values for methanol extracts and various fractions ranged from 0.23-4.30 mg/L gallic acid equivalents and from 30-545 mg/L rutin equivalents, respectively. Overall, methanol extracts and all the fractions of root and aerial parts showed higher TPC and TFC values. Methanol extracts and aqueous fractions of root and aerial parts and the n-butanol fraction of root showed lower EC50 values for 2,2-diphenyl-1-picrylhydrazyl scavenging than the other plant extracts. The 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging, total antioxidant potential and ferric ion reducing antioxidant potential values confirmed the presence of potent antioxidant principles in the methanol extract of roots. In general, all the extracts/fractions and especially those of root showed high antioxidant and radical scavenging activities. CONCLUSIONS:The crude methanol extract of root can be explored further for in vivo studies. This study revealed the potent antioxidant potential of Fagonia cretica and its prospective efficacy against various reactive oxygen species-mediated diseases.
journal_name
Asian Pac J Trop Medjournal_title
Asian Pacific journal of tropical medicineauthors
Iqbal P,Ahmed D,Asghar MNdoi
10.1016/S1995-7645(14)60277-7subject
Has Abstractpub_date
2014-09-01 00:00:00pages
S473-80eissn
1995-7645issn
2352-4146pii
S1995-7645(14)60277-7journal_volume
7S1pub_type
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journal_title：Asian Pacific journal of tropical medicine
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更新日期：2014-09-01 00:00:00
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更新日期：2014-09-01 00:00:00
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更新日期：2011-10-01 00:00:00
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更新日期：2013-11-01 00:00:00
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更新日期：2014-12-01 00:00:00
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更新日期：2014-09-01 00:00:00
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更新日期：2014-11-01 00:00:00
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更新日期：2011-03-01 00:00:00
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journal_title：Asian Pacific journal of tropical medicine
pub_type： 杂志文章
doi：10.1016/S1995-7645(13)60188-1
更新日期：2014-01-01 00:00:00
