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Lagenaria siceraria fruit extract ameliorate fat amassment and serum TNF-α in high-fat diet-induced obese rats.

Abstract：

OBJECTIVE:To investigate the effects of ethanolic extract of Lagenaria siceraria fruit (ELSF) on fat amassment and serum TNF- α in high-fat diet-induced obese rats. METHODS:The high fat diet induced obese rats were orally treated with orlistat (50 mg/kg) and ELSF (100, 200, 300 mg/kg/day) to the respective treatment groups. The body weight, fasting blood glucose level, lipid profile, serum levels of tumor necrosis factor- α (TNF-α) in rats were measured after 30 days of treatment and compared to the obese control animals. RESULTS:ELSF significantly (P < 0.001) reduced the body weight gain, fasting blood glucose, total cholesterol, triglyceride, total protein and TNF-α. CONCLUSIONS:These encouraging findings suggest that Lagenaria siceraria has excellent pharmacological potential to prevent fat amassment.

journal_name

Asian Pac J Trop Med

journal_title

Asian Pacific journal of tropical medicine

authors

Nadeem S,Dhore P,Quazi M,Pawar S,Raj N

doi

10.1016/S1995-7645(12)60109-6

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

698-702

issue

9

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(12)60109-6

journal_volume

5

pub_type

杂志文章

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