Abstract：
OBJECTIVE:To investigate the protective role of Cardiospermum halicacabum (C. halicacabum) leaf extract on glycoprotein metabolism in streptozotocin (STZ)-induced diabetic rats. METHODS:Diabetes was induced in male albino Wistar rats by intraperitonial administration of STZ. The C. halicacabum leaf extract (CHE) was administered orally to normal and STZ-diabetic rats for 45 days. The effects of C. halicacabum leaf extract (CHE) on plasma and tissue glycoproteins (hexose, hexosamine, fucose and sialic acid) were determined. RESULTS:The levels of plasma and tissues glycoproteins containing hexose, hexosamine and fucose were significantly increased in STZ-induced diabetic rats. In addition, the level of sialic acid significantly increased in plasma and liver while decreased in kidney of STZ-induced diabetic rats. After administration of CHE to diabetic rats, the metabolic alteration of glycoprotein reverted towards normal levels. CONCLUSIONS:The present study indicates that the CHE possesses a protective effect on abnormal glycoprotein metabolism in addition to its antihyperglycemic activity.
journal_name
Asian Pac J Trop Medjournal_title
Asian Pacific journal of tropical medicineauthors
Veeramani C,Al-Numair KS,Alsaif MA,Chandramohan G,Al-Numair NS,Pugalendi KVdoi
10.1016/S1995-7645(12)60178-3subject
Has Abstractpub_date
2012-12-01 00:00:00pages
939-44issue
12eissn
1995-7645issn
2352-4146pii
S1995-7645(12)60178-3journal_volume
5pub_type
杂志文章abstract：OBJECTIVE:To observe the protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats. METHODS:All rats were randomly divided into normal control group, cirrhosis and treatment group. Thioacetamide was used to establish rat model of cirrhotic portal hypertension. The necrotic tissue of gast...
journal_title：Asian Pacific journal of tropical medicine
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更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:To discuss the liver function damage mechanism of patients with clonorchiasis by analyzing the ultrasound characteristics, liver function, change of the serum inflammatory factors and cell apoptosis factors. METHODS:Color Doppler ultrasound technique was adopted to detect the portal vein and blood flow chang...
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abstract：OBJECTIVE:To investigate the levels of serum cortisol in patients with uncomplicated Plasmodium falciparum (P. falciparum) malaria in an area of unstable malaria transmission in eastern Sudan. METHODS:The concentrations of cortisol were measured in sera of 25 patients with uncomplicated P. falciparum malaria (at prese...
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更新日期：2015-01-01 00:00:00
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更新日期：2016-04-01 00:00:00
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更新日期：2016-11-01 00:00:00
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更新日期：2014-12-01 00:00:00
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更新日期：2013-10-01 00:00:00
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更新日期：2017-06-01 00:00:00
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journal_title：Asian Pacific journal of tropical medicine
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更新日期：2012-11-01 00:00:00
