Cytoprotective, antihyperglycemic and phytochemical properties of Cocos nucifera (L.) inflorescence.

Abstract:

OBJECTIVE:To analyze the cytoprotective and antidiabetic activities as well as phytochemical composition of the immature inflorescence of Cocos nucifera belonging to the Arecaceae Family. METHODS:The phytochemical screening of inflorescence was done to determine the major constituents present in Cocos nucifera inflorescence. The free radical scavenging potential of inflorescence extracts were evaluated using in vitro radical scavenging assay models. RESULTS:The phytochemical analyses on inflorescence showed the presence of phenolic compounds, flavonoids, resins and alkaloids. The macronutrient analyses, on the other hand, showed the presence of carbohydrate, proteins and fibers. Administration of the methanol extract of coconut inflorescence to the diabetic rats showed dose dependent reduction in hyperglycemia. The cytoprotective property of coconut inflorescence was evidenced from the acute toxicological evaluation. The levels of serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were significantly decreased in the diabetic rats treated with inflorescence when compared with the diabetic control rats. CONCLUSION:The results obtained from the present study apparently proved the non-toxic nature and the cytoprotective and antihyperglycemic properties of coconut inflorescence.

journal_name

Asian Pac J Trop Med

authors

Renjith RS,Chikku AM,Rajamohan T

doi

10.1016/S1995-7645(13)60142-X

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

804-10

issue

10

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(13)60142-X

journal_volume

6

pub_type

杂志文章
  • Antidiarrheal activity of Pterocarpus erinaceus methanol leaf extract in experimentally-induced diarrhea.

    abstract:OBJECTIVE:To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo. METHODS:The methanol leaf extract of Pterocarpus erinaceus was evaluated using different doses (100, 200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea, cha...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(12)60014-5

    authors: Ezeja IM,Ezeigbo II,Madubuike KG,Udeh NE,Ukweni IA,Akomas SC,Ifenkwe DC

    更新日期:2012-02-01 00:00:00

  • The role of heme-oxygenase-1 in pathogenesis of cerebral malaria in the co-culture model of human brain microvascular endothelial cell and ITG Plasmodium falciparum-infected red blood cells.

    abstract:OBJECTIVE:To investigate the role of human host heme-oxygenase-1 (HO-1) in pathogenesis of cerebral malaria in the in vitro model. METHODS:The effect of human host HO-1 [human brain microvascular endothelial cell (HBMEC)] on hemoglobin degradation in the co-culture model of HBMEC and ITG Plasmodium falciparum-infected...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/j.apjtm.2016.11.011

    authors: Thongdee P,Na-Bangchang K

    更新日期:2017-01-01 00:00:00

  • The effect of ischemic precondition to IL-6 on rat liver ischemia-reperfusion injury in transplantation.

    abstract:OBJECTIVE:To investigate the effect of ischemic precondition to protect ischemia-reperfusion injury and reduce IL-6 expression in the rats liver transplantation. METHODS:The rat portal vein infusion of autologous liver transplantation model were used. The rats were divided into ischemic preconditioning rats liver tran...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(13)60045-0

    authors: Cui LZ,Wang B,Chen LY,Zhou J

    更新日期:2013-05-13 00:00:00

  • Preventive and therapeutic effect of simvastatin on secondary inflammatory damage of rats with cerebral hemorrhage.

    abstract:OBJECTIVE:To investigate the preventive and therapeutic effect and mechanism of simvastatin on secondary inflammatory damage of rats with cerebral hemorrhage. METHODS:Sixty SD rat aged 9-12 weeks were chosen and divided into the control group, model group and simvastatin-treated group randomly with 20 rats in each gro...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/j.apjtm.2017.01.003

    authors: Zhou HX,Gao LH,Meng LL,Zhang YX,Wei ZF,Si DW

    更新日期:2017-02-01 00:00:00

  • Acalculous cholecystitis: a rare presentation of leptospirosis progressing to Weil's disease.

    abstract::Leptospirosis is a zoonotic infection with higher incidence in tropics. Leptospirosis, is known for its variable manifestations, and is a clinical challenge for physicians in the tropics. Experienced clinicians, at times can mistake leptospirosis for non-medical conditions. A few reports of leptospirosis presenting as...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(11)60235-6

    authors: Peter G,Narasimha H

    更新日期:2011-12-01 00:00:00

  • Influence of hydrogen sulfide on zymogen activation of homocysteine-induced matrix metalloproteinase-2 in H9C2 cardiocytes.

    abstract:OBJECTIVE:To observe the influence of different concentrations of homocysteine (Hcy) and hydrogen sulfide (H2S) on the secretion and activation of matrix metalloproteinase-2 (MMP-2) in cardiocytes so as to search for new ways to fight against myocardial tissue fibrosis. METHODS:Cardiocytes H9C2 was cultured in vitro a...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/j.apjtm.2016.03.023

    authors: Wang ZS,Jin H,Wang DM

    更新日期:2016-05-01 00:00:00

  • Antihydatic and immunomodulatory effects of Punica granatum peel aqueous extract in a murine model of echinococcosis.

    abstract:OBJECTIVE:To investigate the effect of pomegranate peel aqueous extract (PGE) on the development of secondary experimental echinococcosis and on the viability of Echinococcus granulosus protoscoleces, and the immunomodulatory properties of PGE. METHODS:Swiss mice were inoculated intraperitoneally with viable protoscol...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/j.apjtm.2016.01.038

    authors: Labsi M,Khelifi L,Mezioug D,Soufli I,Touil-Boukoffa C

    更新日期:2016-03-01 00:00:00

  • Mechanism of Japanese encephalitis virus genotypes replacement based on human, porcine and mosquito-originated cell lines model.

    abstract:OBJECTIVE:To examine the multiplication efficiency Japanese encephalitis virus (JEV) genotype I (GI) and genotype III (GIII) of different cell lines which originated from human, porcine, mosquitoes in order to prove mechanism of JEV GI replacement JEV GIII since it emerging in nature recent decades. METHODS:The mixtur...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/j.apjtm.2016.03.007

    authors: Do LP,Bui TM,Phan NT

    更新日期:2016-04-01 00:00:00

  • Induction of deletion mutation on ompR gene of Salmonella enterica serovar Typhi isolates from asymptomatic typhoid carriers to evolve attenuated strains for vaccine development.

    abstract:OBJECTIVE:To develop attenuated strains of Salmonella enterica serovar Typhi (S. typhi) for the candidate vaccine by osmolar stress. METHODS:S. typhi SS3 and SS5 strains were isolated from asymptomatic typhoid carriers in Namakkal, Tamil Nadu, India. Both strains were grown in LB (Luria Bertani) medium supplemented wi...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(14)60165-6

    authors: Senthilkumar B,Anbarasu K,Senbagam D,Rajasekarapandian M

    更新日期:2014-12-01 00:00:00

  • First report on natural Leishmania infection of Phlebotomus sergenti due Leishmania tropica by high resolution melting curve method in South-eastern Iran.

    abstract:OBJECTIVE:To identify the Leishmania species in infected sand flies by Real-time PCR coupled with HRM analysis. METHODS:Real-time PCR coupled with HRM analysis targeting the first internal transcribed spacer (ITS1) of nuclear ribosomal DNA as the genetic marker was used to identify and distinguish Leishmania species i...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(14)60002-X

    authors: Aghaei AA,Rassi Y,Sharifi I,Vatandoost H,Mollaie H,Oshaghi MA,Abai M,Rafizadeh S

    更新日期:2014-02-01 00:00:00

  • Lentivirus vectors construction of SiRNA targeting interference GPC3 gene and its biological effects on liver cancer cell lines Huh-7.

    abstract:OBJECTIVES:To build GPC3 gene short hairpin interference RNA (shRNA) slow virus vector, observe expression of Huh-7 GPC3 gene in human liver cell line proliferation apoptosis and the effect of GPC3 gene influencing on liver cancer cell growth, and provide theoretical basis for gene therapy of liver cancer. METHODS:Hep...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(14)60136-X

    authors: Lei CJ,Yao C,Pan QY,Long HC,Li L,Zheng SP,Zeng C,Huang JB

    更新日期:2014-10-01 00:00:00

  • Spectrum of complications associated with Plasmodium vivax infection in a tertiary hospital in South-Western India.

    abstract:OBJECTIVE:To determine the range and incidence of complications associated with Plasmodium vivax (P. vivax) malaria. METHODS:A retrospective analysis was performed of all patients of P. vivax malaria admitted in Kasturba Medical College, Manipal between January and December, 2010. Patients with mixed malarial infectio...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(11)60251-4

    authors: Naha K,Dasari S,Prabhu M

    更新日期:2012-01-01 00:00:00

  • Screening, phylogenetic analysis and antibiotic sensitivity pattern of Salmonella enterica serovar Typhi isolates from typhoid asymptomatic carriers.

    abstract:OBJECTIVE:To isolate the Salmonella enterica serovar Typhi (S. typhi) from asymptomatic typhoid carriers in the local population. To assess the antibiotic sensitivity and resistant pattern of S. typhi isolates against viable antibiotics and phylogenetic analysis of S. typhi isolates on the basis of 16S rDNA gene. METH...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(11)60191-0

    authors: Chandrasekaran B,Balakrishnan S

    更新日期:2011-10-01 00:00:00

  • Rapid synthesis of biocompatible silver nanoparticles using aqueous extract of Rosa damascena petals and evaluation of their anticancer activity.

    abstract:OBJECTIVE:To optimize the process parameters involved in the green synthesis of silver nanoparticles (G-SNPs) by aqueous extract of Rosa damascena petals and to evaluate the biocompatibility and anti cancer activity of the synthesized silver nanoparticles against human lung adenocarcinoma (A549). METHODS:The process v...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(14)60249-2

    authors: Venkatesan B,Subramanian V,Tumala A,Vellaichamy E

    更新日期:2014-09-01 00:00:00

  • Comparison between recombinant human parathyroid hormone (1-34) and elcatonin in treatment of primary osteoporosis.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of rhPTH (1-34) vs. elcatonin. METHODS:Sixty patients with primary OP were randomly divided into two groups according to the ratio of 3:1. rhPTH (1-34) group (PTH group) was treated with subcutaneous injection of rhPTH (1-34) 20 μ g daily for 18 months, and the elcatonin g...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(14)60192-9

    authors: Yang Y,Zhang XJ,Zhu XJ,Zhang L,Bao MJ,Xian Y,Wu JC,Liu LM,Li PQ

    更新日期:2015-01-01 00:00:00

  • Relationship between gene polymorphisms and prostate cancer risk.

    abstract:OBJECTIVE:To investigate the relationship between genetic factor and prostate cancer (Pca) risk and the possible cause in it. METHODS:The polymorphisms of cytochrome P450 family 17 (CYPl7) rs743572, p27 V109G and androgen receptor (AR) gene CAG repeat length in peripheral blood from 70 cases and 70 controls were detec...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/j.apjtm.2015.06.005

    authors: Han QH,Shan ZJ,Hu JT,Zhang N,Zhang XP

    更新日期:2015-07-01 00:00:00

  • Hepatoprotective and cytoprotective properties of Hyptis suaveolens against oxidative stress-induced damage by CCl(4) and H(2)O(2).

    abstract:OBJECTIVE:To investigate capacity of Hyptis suaveolens (H. suaveolens) methanol extract as an antioxidant to protect against carbon tetrachloride (CCl(4))-induced oxidative stress, hepatotoxicity in Albino Wistar rats and cytoprotective effect of hydrogen peroxide (H(2)O(2)) induced cell death in HepG(2) cell line. ME...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(12)60162-X

    authors: Ghaffari H,Ghassam BJ,Prakash HS

    更新日期:2012-11-01 00:00:00

  • Demonstration of malaria situation analysis, stratification and planning in Minab District, southern Iran.

    abstract:OBJECTIVE:To demonstrate malaria situation analysis, stratification and planning for an endemic area in southern Iran. METHODS:Data on health system, population, meteorological parameters, malaria cases, anopheline vectors, and control activities during 2005-2007 was obtained from Minab Health Center, Minab Meteorolog...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(11)60036-9

    authors: Hassan V,Arash R,Mehdi J,Ahmad R,Ali HB,Wali YA,Ali D,Abdulrasool M,Abbas P

    更新日期:2011-01-01 00:00:00

  • Correlation between single nucleotide polymorphism of rs3811047 in IL-1 F7 gene and rheumatoid arthritis susceptibility among Han population in central plains of China.

    abstract:OBJECTIVE:To discuss the association between single nucleotide polymorphism (SNP) of rs3811047 in IL-1 F7 gene and rheumatoid arthritis (RA) susceptibility among the Han population in central plains of China. METHODS:A total of 276 RA patients admitted to our hospital from December 2009 to December 2011 together with ...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(12)60204-1

    authors: Shi LP,He Y,Liu ZD

    更新日期:2013-01-01 00:00:00

  • A case of advanced mycosis fungoides with comprehensive skin and visceral organs metastasis: sensitive to chemical and biological therapy.

    abstract::Mycosis fungoides is a common cutaneous T-cell lymphoma, which is usually characterized by chronic, indolence progression, with absence of typical symptoms in early stage, metastasis to lymph nodes, bone marrow and visceral organs in later stage and ultimately progression to systemic lymphoma. It can result in seconda...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(12)60138-2

    authors: Liu YQ,Zhu WY,Shu YQ,Gu YH

    更新日期:2012-08-01 00:00:00

  • Efficacy evaluation and kinetic study of biosorption of nickel and zinc by bacteria isolated from stressed conditions in a bubble column.

    abstract:OBJECTIVE:To investigate the biosorption potential of isolated bacteria as an alternative biosorbent material for the removal of zinc and nickel from aqueous solution in a bubble column bioreactor. METHORDS:In this study from four points of waste water treatment plant, some Gram-positive and Gram-negative bacteria und...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(14)60231-5

    authors: Arjomandzadegan M,Rafiee P,Moraveji MK,Tayeboon M

    更新日期:2014-09-01 00:00:00

  • Effects of rhBNP after PCI on non-invasive hemodynamic in acute myocardial infarction patients with left heart failure.

    abstract:OBJECTIVE:To investigate the effects of exogenous recombinant human brain natriuretic peptide (rhBNP) after primary percutaneous coronary intervention (PCI) on non-invasive hemodynamic in acute myocardial infarction patients with left ventricular failure. METHODS:A number of 96 acute myocardial infarction patients acc...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/j.apjtm.2016.06.006

    authors: He XM,Chen L,Luo JB,Feng XX,Zhang YB,Chen QJ,Ji XL,Wang TS

    更新日期:2016-08-01 00:00:00

  • Effect of Chinese herbal compound on liver fibrosis in rabbits with schistosomiasis by B-ultrasound.

    abstract:OBJECTIVE:To explore the value of B-ultrasound on the evaluation of the effects of traditional Chinese medicine compound of Radix astragali, Salvia miltiorrhiza and Angelica sinensis, and TCM + praziquantel on liver fibrosis in rabbits with schistosomiasis. METHODS:The hepatic fibrosis model in rabbits with schistosom...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(13)60114-5

    authors: Liang XL,Yuan JY

    更新日期:2013-08-01 00:00:00

  • Asymptomatic malaria parasitemia does not induce additional oxidative stress in pregnant women of South East Nigeria.

    abstract:OBJECTIVE:To determine the relationship between asymptomatic malaria parasitemia and some oxidative stress parameters in pregnant Nigerian women. METHODS:This is a cross-sectional study involving 130 normal pregnant women at various trimesters, who were attending antenatal clinic at the University of Nigeria Teaching ...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(11)60076-X

    authors: Nwagha UI,Okeke TC,Nwagha TU,Ejezie FE,Ogbodo SO,Dim CC,Anyaehie BU

    更新日期:2011-03-01 00:00:00

  • Suppressive effect of pectic polysaccharides extracted from Rauwolfia verticillata (Lour.) Baill.var.hainanensis Tsiang on inflammation by regulation of NF- κ B pathway and interleukin-17 in mice with dextran sulphatesodium-induced ulcerative colitis.

    abstract:OBJECTIVE:To investigate the effects of pectic polysaccharides extracted from Rauwolfia verticillata (Lour.) Baill.var.hainanensis Tsiang on an experimental murine colitis model. METHODS:Experimental colitis was induced by dextran sulfate sodium (DSS), and mice were divided into 4 groups: control, DSS alone, DSS plus ...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(14)60306-0

    authors: Miao XP,Sun XN,Cui LJ,Cao QF,Zhuang GF,Deng TZ,Zhang DY

    更新日期:2015-02-01 00:00:00

  • Immunoprophylactic potential of filarial glutathione-s-transferase in lymphatic filariaisis.

    abstract:OBJECTIVE:To elucidates the immunoprophylactic potential of glutathion-s-transferase (GST) from cattle filarial parasite Setaria digitata (S. digitata) against lymphatic filariasis. METHODS:GST was purified through affinity chromatography (SdGST) and chacterized by SDS-PAGE and Nano-LC MS/MS analysis. Antibody isotype...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(11)60066-7

    authors: Bal M,Mandal N,Achary KG,Das MK,Kar SK

    更新日期:2011-03-01 00:00:00

  • Nephroprotective effect of Murraya koenigii on cyclophosphamide induced nephrotoxicity in rats.

    abstract:OBJECTIVE:To evaluate the nephroprotective effect of defatted methanolic extract and aqueous extract of Murraya koenigii (M. koenigii) against cyclophosphamide drug. METHODS:Nephrotoxicity was induced by cyclophosphamide in 7 days at 150 mg/kg body weight through intraperitoneal route in rat model. Nephroprotective ac...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/j.apjtm.2017.08.005

    authors: Mahipal P,Pawar RS

    更新日期:2017-08-01 00:00:00

  • Mosquito larvicidal and pupicidal activity of Euphorbia hirta Linn. (Family: Euphorbiaceae) and Bacillus sphaericus against Anopheles stephensi Liston. (Diptera: Culicidae).

    abstract:OBJECTIVE:To explore the larvicidal and pupicidal activity of Euphorbia hirta (E. hirta) leaf extract and Bacillus sphaericus (B. sphaericus) against the malarial vector, Anopheles stephensi (An. stephensi). METHODS:The larvicidal and pupicidal activity was assayed against An. stephensi at various concentrations rangi...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(13)60003-6

    authors: Panneerselvam C,Murugan K,Kovendan K,Kumar PM,Subramaniam J

    更新日期:2013-02-01 00:00:00

  • Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients.

    abstract:OBJECTIVE:To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin (HbA(1c)). METHODS:Samples were collected from 128 type 2 diabetic patients (aged 19-90 years; male 72, female 56). The sera were analyzed for HbA(1c), total cholesterol (TC), t...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/S1995-7645(12)60080-7

    authors: Yan Z,Liu Y,Huang H

    更新日期:2012-06-01 00:00:00

  • Identifications of drug resistance mutations among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia.

    abstract:OBJECTIVE:To determine drug resistance mutations and the HIV-1 subtypes among antiretroviral treatment naive HIV-1 patients in Peninsular Malaysia. METHODS:A total of 45 samples from four hospitals that provide HIV viral load services were subjected to the amplification of the protease and two third of reverse transcr...

    journal_title:Asian Pacific journal of tropical medicine

    pub_type: 杂志文章

    doi:10.1016/j.apjtm.2016.12.005

    authors: Zain RM,Ibrahim N,Ismail S,Suppiah J,Mat Rahim NA,Thayan R

    更新日期:2017-01-01 00:00:00