当前位置： SCI文献检索 > Asian Pacific Journal of Tropical Medicine期刊下所有文献 > Antipyretic, anti-inflammatory and analgesic properties of nilavembu kudineer choornam: a classical preparation used in the treatment of chikungunya fever.

Antipyretic, anti-inflammatory and analgesic properties of nilavembu kudineer choornam: a classical preparation used in the treatment of chikungunya fever.

Abstract：

OBJECTIVE:To investigate the efficacy of ethanolic extract of nilavembu kudineer choornam (EENKC) in inflammation, pain and fever using animal models to support its actions. METHODS:Acute toxicity study of EENKC was performed in mice to fix the effective dose. The antipyretic, anti-inflammatory and analgesic activity of EENKC was evaluated in brewer's yeast induced pyrexia in rats, carrageenan-induced inflammation in rats and acetic-acid induced writhing in mice model. RESULTS:Acute toxicity revealed that EENKC didn't show death and toxic signs up to 2 000 mg/kg. In brewer's yeast induced pyrexia and carrageenan-induced inflammation EENKC at the doses of 200 and 400 mg/kg inhibited fever and inflammation significantly (P<0.01 and <0.05) compared to control animals. In mice, the number of writhing induced by acetic-acid was significantly (P<0.01) reduced after treatment with both the dose of EENKC than control animals. EENKC 200 mg/kg inhibits inflammation higher level in carrageenan-induced paw edema, but there is no significant difference when compared to indomethacin 10 mg/kg. CONCLUSIONS:The present findings revealed that EENKC possesses antipyretic, anti-inflammatory and analgesic activity which supports nilavembu kudineer choornam efficacy in chikungunya fever.

journal_name

Asian Pac J Trop Med

journal_title

Asian Pacific journal of tropical medicine

authors

Anbarasu K,Manisenthil KK,Ramachandran S

doi

10.1016/S1995-7645(11)60201-0

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

819-23

issue

10

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(11)60201-0

journal_volume

4

pub_type

杂志文章

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