Anti-hyperglycemic activity of leaves extract of Hyptis suaveolens L. Poit in streptozotocin induced diabetic rats.

Abstract:

OBJECTIVE:To evaluate the antihyperglycemic activity of leaves of Hyptis suaveolens using streptozotocin model. METHODS:Hyptis suaveolens extract (HSE) 250 and 500 mg/kg body weight was administered orally to streptozotocin induced diabetes, once daily for 21 days. RESULTS:A significant reduction in blood glucose was observed in diabetic animals treated with HSE at different doses when compared with diabetic rats. Levels of triglyceride, total cholesterol, low density lipoprotein, very low density lipoprotein were decreased while administering HSE at different doses, compared with their control values in diabetic animals. CONCLUSIONS:Our results show that HSE possesses significant antihyperglycemic activity which might be attributed to stimulating effects on glucose utilization and antioxidant enzyme.

journal_name

Asian Pac J Trop Med

authors

Mishra SB,Verma A,Mukerjee A,Vijayakumar M

doi

10.1016/S1995-7645(11)60175-2

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

689-93

issue

9

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(11)60175-2

journal_volume

4

pub_type

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