当前位置： SCI文献检索 > Asian Pacific Journal of Tropical Medicine期刊下所有文献 > Isolation and characterization of anti-diabetic component (bioactivity-guided fractionation) from Ocimum sanctum L. (Lamiaceae) aerial part.

Isolation and characterization of anti-diabetic component (bioactivity-guided fractionation) from Ocimum sanctum L. (Lamiaceae) aerial part.

Abstract：

OBJECTIVE:To isolate and characterize antidiabetic component (bioactivity-guided fractionation) from hydro alcoholic extract of Ocimum sanctum (O. sanctum) aerial part. METHODS:Ten fractions (F1-F10) were isolated from hydro alcoholic extract of O. sanctum aerial part by column chromatography. All the fractions F1 to F10 were screened for antidiabetic activity in alloxan induced diabetic rats by estimating serum glucose level and lipid parameters. The isolated bioactive component was elucidated on the basis of extensive spectroscopic (UV, IR, MS, (1)H and (13)C NMR) data analysis. RESULTS:The bioactive fraction (F5) was found to be potent antidiabetic by ameliorating glucose and lipid parameters (total cholesterol, triglycerides, low and high density lipoprotein cholesterol). The extensive spectroscopic data analysis reveals that, the isolated bioactive compound elucidated as tetracyclic triterpenoid [16-hydroxy-4,4,10,13-tetramethyl-17-(4-methyl-pentyl)-hexadecahydro-cyclopenta[a]phenanthren-3-one]. CONCLUSIONS:Our present study concluded that, tetracyclic triterpenoid isolated from aerial part of O. sanctum has a great anti-diabetic potential.

journal_name

Asian Pac J Trop Med

journal_title

Asian Pacific journal of tropical medicine

authors

Patil R,Patil R,Ahirwar B,Ahirwar D

doi

10.1016/S1995-7645(11)60086-2

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

278-82

issue

4

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(11)60086-2

journal_volume

4

pub_type

杂志文章

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