Effect of sex steroids on GABA receptors in the rat hypothalamus and anterior pituitary gland.

abstract：:Previous studies from this laboratory suggested that two subtypes of substance P receptor may exist, based on the observations that substance P and related peptides did not exhibit complete cross-desensitisation on guinea-pig ileum, and that two distinct rank orders of potency of tachykinins were observed in various t...

journal_title：European journal of pharmacology

authors： Watson SP,Sandberg BE,Hanley MR,Iversen LL

更新日期：1983-01-28 00:00:00

abstract：:The present investigation was designed to identify potential biomarker(s) and assess the involvement of inflammatory pathway in dimethylnitrosamine (DMN)-induced liver fibrosis in rats. Following DMN-treatment (10 mg/ml/kg, i.p., given three consecutive days each week for 4 weeks) body and liver weights were significa...

journal_title：European journal of pharmacology

authors： Saha JK,Xia J,Sandusky GE,Chen YF,Gerlitz B,Grinnell B,Jakubowski JA

更新日期：2007-12-01 00:00:00

abstract：:Identification of immunosuppressants from natural sources has a proven track record in immune mediated disorders. Pseudolaric acid B is a diterpenoid isolated from the roots of Pseudolarix amabilis, possessing potent immunomodulatory effect. However, the cytotoxicity limits its future clinical application. The purpose...

journal_title：European journal of pharmacology

authors： Li T,Chen H,Yang Z,Wang W,Wang YT,Zhang LM,Zhao JH,Zhou X,Li YM

更新日期：2014-12-15 00:00:00

abstract：:Cocaine and a cocaine analog, WIN 36,065-2, were administered daily for 3 or 4 days. Both compounds developed sensitization to their locomotor stimulatory effects, with similarly shaped dose-response curves. Dosages giving optimal sensitization were 25 mg/kg per day for cocaine and 3 mg/kg for WIN 35,065-2. At 40 mg/k...

journal_title：European journal of pharmacology

authors： Reith ME

更新日期：1986-10-14 00:00:00

abstract：:Nicorandil is an adenosine triphosphate-sensitive potassium channel opener with additional antioxidant properties. Doxorubicin (DOX) is an anticancer drug that exerts oxidation-mediated adverse cardiovascular effects. This study examined the effects of nicorandil on DOX-induced cytotoxicity in human umbilical vein end...

journal_title：European journal of pharmacology

authors： Chen CC,Hong HJ,Hao WR,Cheng TH,Liu JC,Sung LC

更新日期：2019-09-15 00:00:00

abstract：:Low levels of serotonin may reduce the density of the serotonin transporter (SERT) by either increasing trafficking or reducing synthesis; a "neuroadaptive response". To determine whether 3,4-methylenedioxymethamphetamine (MDMA)-induced reductions in SERT density could be related to such a mechanism, p-chlorophenylala...

journal_title：European journal of pharmacology

authors： Boot BP,Mechan AO,McCann UD,Ricaurte GA

更新日期：2002-10-25 00:00:00

abstract：:Atherosclerosis is a leading cause of death worldwide. It is a complex chronic inflammatory disease involving interactions between vascular, circulating and immune cells. B cells play an important role in chronic inflammation producing antibodies and regulating T and natural killer (NKT) cell activation. The role of B...

journal_title：European journal of pharmacology

authors： Nus M,Tsiantoulas D,Mallat Z

更新日期：2017-12-05 00:00:00

abstract：:The effects of alpha 1-adrenergic stimulation on intracellular pH (pHi) and Ca2+ concentration ([Ca2+]i) were investigated in isolated rat cardiomyocytes with fluorescence dyes, BCECF and fura-2, respectively. In the presence of 5 or 25 mM HCO3- norepinephrine (NE) increased pHi in a dose-dependent manner. Intracellul...

journal_title：European journal of pharmacology

authors： Iwakura K,Hori M,Watanabe Y,Kitabatake A,Cragoe EJ Jr,Yoshida H,Kamada T

更新日期：1990-09-04 00:00:00

abstract：:Selective L-type voltage-operated calcium channel (VOCC) antagonists nicardipine, diltiazem and verapamil all produced pronounced falls in mean arterial blood pressure (MAP) in the anaesthetized artificially ventilated guinea-pig. This fall in MAP was associated with a significant reduction of the pressor response ind...

journal_title：European journal of pharmacology

authors： Bond A,Boot JR

更新日期：1992-07-21 00:00:00

abstract：:We evaluated the effects of ACEA (selective cannabinoid (CB)1 receptor agonist), WIN 55,212-2 mesylate (WIN; non-selective CB1 and CB2 receptor agonist) and N-palmitoylethanolamine (PEA; an endogenous fatty acid of ethanolamide) in DBA/2 mice, a genetic model of reflex audiogenic epilepsy. PEA, ACEA or WIN intraperito...

journal_title：European journal of pharmacology

authors： Citraro R,Russo E,Leo A,Russo R,Avagliano C,Navarra M,Calignano A,De Sarro G

更新日期：2016-11-15 00:00:00

abstract：:Nausea and vomiting are among the most common and distressing consequences of cytotoxic chemotherapies. Nausea and vomiting can be acute (0-24h) or delayed (24-72 h) after chemotherapy administration. The introduction of 5-HT(3) receptor antagonists in the 90s was a major advance in the prevention of acute emesis. The...

journal_title：European journal of pharmacology

authors： Rojas C,Slusher BS

更新日期：2012-06-05 00:00:00

abstract：:In this study we compared characteristics of (-)-[3H]dihydroalprenolol ([3H]DHA) binding sites in crude membrane preparations of human peripheral blood lymphocytes with those of intact, viable cells. A valid determination of specific beta-adrenergic receptor binding in both preparations was obtained by defining non-sp...

journal_title：European journal of pharmacology

authors： Meurs H,van den Bogaard W,Kauffman HF,Bruynzeel PL

更新日期：1982-11-19 00:00:00

abstract：:Dorsal root potentials were recorded from urethane-anaesthetised rats. Bicuculline, a recognised GABA antagonist, reduced the amplitude of the potential to 67% of control. Cismethrin, a synthetic pyrethroid insecticide, enhanced the potential to 142% of control values. The convulsions associated with cismethrin poison...

journal_title：European journal of pharmacology

authors： Smith PR

更新日期：1980-08-22 00:00:00

abstract：:The effects of famotidine on the cardiac repolarization process were assessed using four different levels of test systems described in the draft stage guideline ICH S7B. A supratherapeutic concentration of famotidine (10(-5) M), which is >8 times higher than C(max) obtained after its therapeutic dose, neither inhibite...

journal_title：European journal of pharmacology

authors： Sugiyama A,Satoh Y,Takahara A,Nakamura Y,Shimizu-Sasamata M,Sato S,Miyata K,Hashimoto K

更新日期：2003-04-11 00:00:00

abstract：:We examined the effects of (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409), a nitric oxide (NO) donor, on renal actions and norepinephrine overflow induced by renal nerve stimulation in anesthetized dogs, with or without N(G)-nitro-L-arginine (NOARG), a NO synthase inhibitor. Renal nerve stimulatio...

journal_title：European journal of pharmacology

authors： Tadano K,Matsuo G,Hashimoto T,Matsumura Y

更新日期：1998-01-12 00:00:00

abstract：:Environments previously associated with drug use can become one of the most common factors triggering relapse to drug-seeking behavior. To better understand the neurochemical mechanisms potentially mediating these cues, we measured nucleus accumbens dopamine levels in animals exposed to environmental cues previously p...

journal_title：European journal of pharmacology

authors： Gerasimov MR,Schiffer WK,Gardner EL,Marsteller DA,Lennon IC,Taylor SJ,Brodie JD,Ashby CR Jr,Dewey SL

更新日期：2001-03-02 00:00:00

abstract：:The effects of veratrine and veratridine on the release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) from incubations of pituitary alone, hypothalamus alone, and coincubations of hypothalamus and pituitary were examined. Veratrine produced only small increases in LH secretion from pituitaries ...

journal_title：European journal of pharmacology

authors： Powers CA,Johnson DC

更新日期：1980-08-29 00:00:00

abstract：:The effect of Bay K 8644 on contractile responses to angiotensin II (AII) was investigated in rabbit aorta. Bay K 8644 alone did not elicit contraction while contractile responses to AII were enhanced at low concentrations (10(-8), 3 X 10(-8), 10(-7) M) and depressed at a higher concentration (10(-6) M). The potentiat...

journal_title：European journal of pharmacology

authors： Roy F,Pruneau D

更新日期：1986-07-15 00:00:00

abstract：:The effects of intra- and extraluminal capsaicin administration were evaluated in isolated perfused rat mesenteric bed. Capsaicin (10 nM-1 microM) produced a potent concentration-dependent relaxation of the tonic vasoconstriction induced by norepinephrine (1 microM) but not by high-K+ (60 mM). The capsaicin-induced re...

journal_title：European journal of pharmacology

authors： Manzini S,Perretti F

更新日期：1988-03-29 00:00:00

abstract：:The aim of the present research was to characterize the pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel quinazolinone-based dipeptidyl peptidase-4 (DPP-4) inhibitor. Alogliptin potently inhibited human DPP-4 in vitro (mean IC(50), ~ 6.9 nM) and exhibited > 10,000-fold selectivity for DPP...

journal_title：European journal of pharmacology

authors： Lee B,Shi L,Kassel DB,Asakawa T,Takeuchi K,Christopher RJ

更新日期：2008-07-28 00:00:00

abstract：:The K562 cell line has been proposed as a useful experimental system to identify anti-tumor compounds acting by inducing terminal erythroid differentiation. K562 cells exhibit a low proportion of hemoglobin-synthesizing cells under standard cell growth conditions, but are able to undergo terminal erythroid differentia...

journal_title：European journal of pharmacology

authors： Brognara E,Lampronti I,Breveglieri G,Accetta A,Corradini R,Manicardi A,Borgatti M,Canella A,Multineddu C,Marchelli R,Gambari R

更新日期：2011-12-15 00:00:00

abstract：:Antagonists, but not agonists, of the 5-HT3 receptor are useful therapeutic agents, and it is possible that partial agonists may also be potentially useful in the clinic. Here we show that 5-fluorotryptamine (5-FT) is a partial agonist at both 5-HT3A and 5-HT3AB receptors with an Rmax (Imax/Imax 5-HT) of 0.64 and 0.45...

journal_title：European journal of pharmacology

authors： Bower KS,Price KL,Sturdee LE,Dayrell M,Dougherty DA,Lummis SC

更新日期：2008-02-12 00:00:00

abstract：:Ulcerative colitis (UC), as an autoimmune disease, has been troubling human health for many years. Up to now, the available treatments remain unsatisfactory. Rhizoma Coptidis has been widely applied to treat gastrointestinal diseases in China for a long time, and coptisine (COP) is identified as one of its major activ...

journal_title：European journal of pharmacology

authors： Wang Y,Liu J,Huang Z,Li Y,Liang Y,Luo C,Ni C,Xie J,Su Z,Chen J,Li C

更新日期：2021-01-25 00:00:00

abstract：:In cultured rat heart muscle cells, reversible long-term ATP depletion induces a decrease in beta-adrenoceptor density and a fall in isoproterenol- as well as forskolin-stimulated cAMP formation. However, isoproterenol-stimulated adenylyl cyclase activity in membrane preparations is not reduced after ATP depletion. Th...

journal_title：European journal of pharmacology

authors： Wagenknecht B,Beuttler C

更新日期：1991-11-13 00:00:00

abstract：:Two novel 8 alpha-amino ergolines (CH 29-717 and CU 32-085) have been shown to inhibit secretion of prolactin in rats in vivo. However, when tested for dopaminomimetic potency on pituitary cell culture preparations in vitro, CH 29-717 inhibited prolactin release with an IC50 = 4 X 10(-9) M. In the same model the 1-met...

journal_title：European journal of pharmacology

authors： Markó M

更新日期：1984-06-01 00:00:00

abstract：:(-)-3/-Norepinephrine (3H-NE) binding to the microsomal fraction of the rabbit aorta has been studied. Binding appears to increase linearly with time up to at least 30 min, shows no evidence of stereoselectivity and may be inhibited only by compounds possessing the catechol or 3-methoxy-4hydroxyphenyl moieties, with t...

journal_title：European journal of pharmacology

authors： Ruffolo RR,Mccreery RL,Patil PN

更新日期：1976-08-01 00:00:00

abstract：:Receptor for advanced glycation end-products (RAGE) is involved in the pathogenesis of diabetic nephropathy. FPS-ZM1, a selective RAGE inhibitor, in combination with valsartan were investigated for their protective potentials on the renal markers of tubular injury in streptozotocin-induced diabetic rats. Rats were ass...

journal_title：European journal of pharmacology

authors： Sanajou D,Ghorbani Haghjo A,Argani H,Roshangar L,Rashtchizadeh N,Ahmad SNS,Ashrafi-Jigheh Z,Bahrambeigi S,Asiaee F,Rashedi J,Aslani S

更新日期：2019-01-05 00:00:00

abstract：:The effects of omega-conotoxin GVIA (omega-CgTx), a peptide isolated from the venom of a marine mollusc, were studied in rat hippocampal neurons. Intracellular recordings from the CA1 area were made for the purpose in in vitro slice preparations. Omega-CgTx (0.1-1 microM) rapidly and irreversibly blocked the EPSP and ...

journal_title：European journal of pharmacology

authors： Dutar P,Rascol O,Lamour Y

更新日期：1989-12-19 00:00:00

abstract：:Perfusion of the 1S,3R isomer of trans-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD, 50 microM), or arachidonic acid (10 microM), for 5 min produced only depression of the field excitatory postsynaptic potential recorded in the CA1 region of rat hippocampal slices from which the CA3 region had been removed. However...

journal_title：European journal of pharmacology

authors： Collins DR,Davies SN

更新日期：1993-08-24 00:00:00

abstract：:Glial cells express thromboxane A(2) receptor, but its physiological role remains unknown. The present study was performed to examine thromboxane A(2) receptor-mediated morphological change in 1321N1 human astrocytoma cells. Thromboxane A(2) receptor agonists U46619 and STA(2) caused a rapid morphological change to sp...

journal_title：European journal of pharmacology

authors： Honma S,Saika M,Ohkubo S,Kurose H,Nakahata N

更新日期：2006-09-18 00:00:00