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Sensing inhomogeneous mechanical properties of human corneal Descemet's membrane with AFM nano-indentation.

Abstract：

:The paper describes a highly space-resolved characterization of the surface mechanical properties of the posterior human corneal layer (Descemet's membrane). This has been accomplished with Atomic Force Microscopy (AFM) nano-indentation by using a probe with a sharp tip geometry. Results indicate that the contact with this biological tissue in liquid occurs with no (or very low) adhesion. More importantly, under the same operating conditions, a broad distribution of penetration depth can be measured on different x-y positions of the tissue surface, indicating a high inhomogeneity of surface stiffness, not yet clearly reported in the literature. An important contribution to such inhomogeneity should be ascribed to the discontinuous nature of the collagen/proteoglycans fibers matrix tissue, as can be imaged by AFM when the tissue is semi-dry. Using classical contact mechanics calculations adapted to the specific geometry of the tetrahedral tip it has been found that the elastic modulus E of the material in the very proximity of the surface ranges from 0.23 to 2.6 kPa.

journal_name

J Mech Behav Biomed Mater

journal_title

Journal of the mechanical behavior of biomedical materials

authors

Di Mundo R,Recchia G,Parekh M,Ruzza A,Ferrari S,Carbone G

doi

10.1016/j.jmbbm.2017.05.019

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

21-27

eissn

1751-6161

issn

1878-0180

pii

S1751-6161(17)30207-2

journal_volume

74

pub_type

杂志文章

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