相关文献
eLife文献大全abstract::Sensory deprivation during the post-natal 'critical period' leads to structural reorganization of the developing visual cortex. In adulthood, the visual cortex retains some flexibility and adapts to sensory deprivation. Here we show that short-term (2 hr) monocular deprivation in adult humans boosts the BOLD response ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40014
更新日期:2018-11-26 00:00:00
abstract::The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.60673
更新日期:2020-11-04 00:00:00
abstract::Mitochondrial division, essential for survival in mammals, is enhanced by an inter-organellar process involving ER tubules encircling and constricting mitochondria. The force for constriction is thought to involve actin polymerization by the ER-anchored isoform of the formin protein inverted formin 2 (INF2). Unknown i...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.08828
更新日期:2015-08-25 00:00:00
abstract::Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the parent. Lamina-associated domains (LADs) are regions of repressi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49278
更新日期:2019-10-01 00:00:00
abstract::The human insular cortex is a heterogeneous brain structure which plays an integrative role in guiding behavior. The cytoarchitectonic organization of the human insula has been investigated over the last century using postmortem brains but there has been little progress in noninvasive in vivo mapping of its microstruc...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53470
更新日期:2020-06-04 00:00:00
abstract::Microbes are embedded in complex communities where they engage in a wide array of intra- and inter-specific interactions. The extent to which these interactions drive or impede microbiome diversity is not well understood. Historically, two contrasting hypotheses have been suggested to explain how species interactions ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58999
更新日期:2020-11-20 00:00:00
abstract::Calcium is a critical second messenger in neurons that contributes to learning and memory, but how the coordination of action potentials of neuronal ensembles with the hippocampal local field potential (LFP) is reflected in dynamic calcium activity remains unclear. Here, we recorded hippocampal calcium activity with e...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39777
更新日期:2019-03-07 00:00:00
abstract::Centering and decentering of cellular components is essential for internal organization of cells and their ability to perform basic cellular functions such as division and motility. How cells achieve proper localization of their organelles is still not well-understood, especially in large cells such as oocytes. Here, ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55368
更新日期:2020-04-21 00:00:00
abstract::Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases attenuate β-adrenergic signaling in white adipose tissue. Treatment of 3T3-L1 adipocytes with specific inhibitors of the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01119
更新日期:2013-12-24 00:00:00
abstract::The expression of E-Cadherin, a protein best known for its role in cell adhesion, regulates the onset of embryonic differentiation. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.01839
更新日期:2013-12-17 00:00:00
abstract::Glutaminase (GLS) isoenzymes GLS1 and GLS2 are key enzymes for glutamine metabolism. Interestingly, GLS1 and GLS2 display contrasting functions in tumorigenesis with elusive mechanism; GLS1 promotes tumorigenesis, whereas GLS2 exhibits a tumor-suppressive function. In this study, we found that GLS2 but not GLS1 binds ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10727
更新日期:2016-01-11 00:00:00
abstract::β-Propellers arise through the amplification of a supersecondary structure element called a blade. This process produces toroids of between four and twelve repeats, which are almost always arranged sequentially in a single polypeptide chain. We found that new propellers evolve continuously by amplification from single...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49853
更新日期:2019-10-15 00:00:00
abstract::Using knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on the representation...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30373
更新日期:2018-03-07 00:00:00
abstract::Why does a first pregnancy after age 35 increase the risk of breast cancer, and what can be done to combat this? ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.01926
更新日期:2013-12-31 00:00:00
abstract::New ages for flowstone, sediments and fossil bones from the Dinaledi Chamber are presented. We combined optically stimulated luminescence dating of sediments with U-Th and palaeomagnetic analyses of flowstones to establish that all sediments containing Homo naledi fossils can be allocated to a single stratigraphic ent...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.24231
更新日期:2017-05-09 00:00:00
abstract::Actin dynamics generate forces to deform the membrane and overcome the cell's high turgor pressure during clathrin-mediated endocytosis (CME) in yeast, but precise molecular details are still unresolved. Our previous models predicted that actin filaments of the endocytic meshwork continually polymerize and disassemble...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52355
更新日期:2019-12-19 00:00:00
abstract::CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator complex. We discov...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37084
更新日期:2018-05-29 00:00:00
abstract::Smoothened (Smo) inhibition by Patched (Ptch) is central to Hedgehog (Hh) signaling. Ptch, a proton driven antiporter, is required for Smo inhibition via an unknown mechanism. Hh ligand binding to Ptch reverses this inhibition and activated Smo initiates the Hh response. To determine whether Ptch inhibits Smo strictly...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.17634
更新日期:2016-08-23 00:00:00
abstract::Cardiac conduction defects decrease life expectancy in myotonic dystrophy type 1 (DM1), a CTG repeat disorder involving misbalance between two RNA binding factors, MBNL1 and CELF1. However, how DM1 condition translates into conduction disorders remains poorly understood. Here we simulated MBNL1 and CELF1 misbalance in...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51114
更新日期:2019-12-12 00:00:00
abstract::Vitamin B12 (cobalamin) is the most complex B-type vitamin and is synthetized exclusively in a limited number of prokaryotes. Its biologically active variants contain rare organometallic bonds, which are used by enzymes in a variety of central metabolic pathways such as L-methionine synthesis and ribonucleotide reduct...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35828
更新日期:2018-05-29 00:00:00
abstract::Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently activated by trisomy 21 in human cells. Transcriptome analysis rev...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.16220
更新日期:2016-07-29 00:00:00
abstract::Neoangiogenesis is a pivotal therapeutic target in glioblastoma. Tumor monitoring requires imaging methods to assess treatment effects and disease progression. Until now mapping of the tumor vasculature has been difficult. We have developed a combined magnetic resonance and optical toolkit to study neoangiogenesis in ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11712
更新日期:2016-02-02 00:00:00
abstract::We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism was unknown. Here we show E. faecium has unique peptidoglycan comp...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.45343
更新日期:2019-04-10 00:00:00
abstract::Muscles organise pseudo-crystalline arrays of actin, myosin and titin filaments to build force-producing sarcomeres. To study sarcomerogenesis, we have generated a transcriptomics resource of developing Drosophila flight muscles and identified 40 distinct expression profile clusters. Strikingly, most sarcomeric compon...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34058
更新日期:2018-05-30 00:00:00
abstract::The application of current channelrhodopsin-based optogenetic tools is limited by the lack of strict ion selectivity and the inability to extend the spectra sensitivity into the near-infrared (NIR) tissue transmissible range. Here we present an NIR-stimulable optogenetic platform (termed 'Opto-CRAC') that selectively ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10024
更新日期:2015-12-08 00:00:00
abstract::A mathematical model shows how the shape of early multicellular organisms may have helped cells evolve specialized roles. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.63328
更新日期:2020-11-03 00:00:00
abstract::Coat protein complex II (COPII) mediates formation of the membrane vesicles that export newly synthesised proteins from the endoplasmic reticulum. The inner COPII proteins bind to cargo and membrane, linking them to the outer COPII components that form a cage around the vesicle. Regulated flexibility in coat architect...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00951
更新日期:2013-09-17 00:00:00
abstract::Cytomegaloviruses (CMVs) are ubiquitous pathogens known to employ numerous immunoevasive strategies that significantly impair the ability of the immune system to eliminate the infected cells. Here, we report that the single mouse CMV (MCMV) protein, m154, downregulates multiple surface molecules involved in the activa...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50803
更新日期:2020-01-13 00:00:00
abstract::Developing neurons of the peripheral nervous system reach their targets via cues that support directional growth, a process known as axon guidance. In investigating how sympathetic axons reach the heart in mice, we discovered that a combination of guidance cues are employed in sequence to refine axon outgrowth, a proc...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.42528
更新日期:2019-02-08 00:00:00
abstract::The insular cortex (IC) plays key roles in emotional and regulatory brain functions and is affected across psychiatric diseases. However, the brain-wide connections of the mouse IC have not been comprehensively mapped. Here, we traced the whole-brain inputs and outputs of the mouse IC across its rostro-caudal extent. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55585
更新日期:2020-09-17 00:00:00