Abstract:
:The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of a human brain, our study showed that the dominant axis of MTL cytoarchitectural differentiation follows the iso-to-allocortical transition and depth-specific variations in neuronal density. Projecting the histology-derived MTL model to in-vivo functional MRI, we furthermore determined how its cytoarchitecture underpins its intrinsic effective connectivity and association to large-scale networks. Here, the cytoarchitectural gradient was found to underpin intrinsic effective connectivity of the MTL, but patterns differed along the anterior-posterior axis. Moreover, while the iso-to-allocortical gradient parametrically represented the multiple-demand relative to task-negative networks, anterior-posterior gradients represented transmodal versus unimodal networks. Our findings establish that the combination of micro- and macrostructural features allow the MTL to represent dominant motifs of whole-brain functional organisation.
journal_name
Elifejournal_title
eLifeauthors
Paquola C,Benkarim O,DeKraker J,Larivière S,Frässle S,Royer J,Tavakol S,Valk S,Bernasconi A,Bernasconi N,Khan A,Evans AC,Razi A,Smallwood J,Bernhardt BCdoi
10.7554/eLife.60673subject
Has Abstractpub_date
2020-11-04 00:00:00issn
2050-084Xpii
60673journal_volume
9pub_type
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