Abstract:
:A mathematical model shows how the shape of early multicellular organisms may have helped cells evolve specialized roles.
journal_name
Elifejournal_title
eLifeauthors
Staps M,Tarnita Cdoi
10.7554/eLife.63328subject
Has Abstractpub_date
2020-11-03 00:00:00issn
2050-084Xpii
63328journal_volume
9pub_type
评论,杂志文章相关文献
eLife文献大全abstract::We reveal a novel mechanism that explains how preparatory activity can evolve in motor-related cortical areas without prematurely inducing movement. The smooth eye movement region of the frontal eye fields (FEFSEM) is a critical node in the neural circuit controlling smooth pursuit eye movement. Preparatory activity e...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50962
更新日期:2020-02-21 00:00:00
abstract::Clinical trials are currently underway to assess the efficacy of forniceal deep brain stimulation (DBS) for improvement of memory in Alzheimer's patients, and forniceal DBS has been shown to improve learning and memory in a mouse model of Rett syndrome (RTT), an intellectual disability disorder caused by loss-of-funct...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34031
更新日期:2018-03-23 00:00:00
abstract::Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. To test whether exosomal RNAs also contribute to changes in gene expression in recipient cells, and whether mutant KRAS might regulate the composition of secreted microRNAs (miRNAs), we compared small RN...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.07197
更新日期:2015-07-01 00:00:00
abstract::Initiatives to improve research communication can benefit from listening to graduate students, postdocs and newly-independent group leaders. ...
journal_title:eLife
pub_type: 社论
doi:10.7554/eLife.36263
更新日期:2018-03-27 00:00:00
abstract::Struggling to get her research project up and running in a new country, a mother gets inspiration from her young daughter. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59587
更新日期:2020-06-10 00:00:00
abstract::In eukaryotes, intra-chromosomal recombination generates DNA circles, but little is known about how cells react to them. In yeast, partitioning of such circles to the mother cell at mitosis ensures their loss from the population but promotes replicative ageing. Nevertheless, the mechanisms of partitioning are debated....
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03790
更新日期:2014-11-17 00:00:00
abstract::Cell growth and/or proliferation may require the reprogramming of metabolic pathways, whereby a switch from oxidative to glycolytic metabolism diverts glycolytic intermediates towards anabolic pathways. Herein, we identify a novel role for TRIM32 in the maintenance of glycolytic flux mediated by biochemical interactio...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52358
更新日期:2020-03-30 00:00:00
abstract::Ten countries have reported pfhrp2/pfhrp3 gene deletions since the first observation of pfhrp2-deleted parasites in 2012. In a previous study (Watson et al., 2017), we characterised the drivers selecting for pfhrp2/3 deletions and mapped the regions in Africa with the greatest selection pressure. In February 2018, the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40339
更新日期:2019-05-02 00:00:00
abstract::Patterns of spatial positioning of individuals within microbial communities are often critical to community function. However, understanding patterning in natural communities is hampered by the multitude of cell-cell and cell-environment interactions as well as environmental variability. Here, through simulations and ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00230
更新日期:2013-01-22 00:00:00
abstract::Drosophila larvae and adults possess a potent innate immune response, but the response of Drosophila eggs is poor. In contrast to Drosophila, eggs of the beetle Tribolium are protected by a serosa, an extraembryonic epithelium that is present in all insects except higher flies. In this study, we test a possible immune...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04111
更新日期:2014-12-09 00:00:00
abstract::The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase. Until now, the regulation that restricts CMG ubiquitylation to terminatio...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.60371
更新日期:2020-08-17 00:00:00
abstract::Cells and organelles are not homogeneous but include microcompartments that alter the spatiotemporal characteristics of cellular processes. The effects of microcompartmentation on metabolic pathways are however difficult to study experimentally. The pyrenoid is a microcompartment that is essential for a carbon concent...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37960
更新日期:2018-10-11 00:00:00
abstract::Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia affecting geographically distant populations of two species of mussels (Mytilus chilensis in South America and M. edulis in Eur...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47788
更新日期:2019-11-05 00:00:00
abstract::AMPARs control fast synaptic communication between neurons and their function relies on auxiliary subunits, which importantly modulate channel properties. Although it has been suggested that AMPARs can bind to TARPs with variable stoichiometry, little is known about the effect that this stoichiometry exerts on certain...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53946
更新日期:2020-05-26 00:00:00
abstract::The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two m...
journal_title:eLife
pub_type:
doi:10.7554/eLife.25835
更新日期:2017-07-06 00:00:00
abstract::The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD225 family and inhibit diverse virus infections. IFITM3 reduces membrane fusion between cells and virions through a poorly characterized mechanism. Mutation of proline-rich transmembrane protein 2 (PRRT2), a regulator of neurotransmitter ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58537
更新日期:2020-10-28 00:00:00
abstract::When a T cell and an antigen-presenting cell form an immunological synapse, rapid dynein-driven translocation of the centrosome toward the contact site leads to reorganization of microtubules and associated organelles. Currently, little is known about how the regulation of microtubule dynamics contributes to this proc...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.62876
更新日期:2020-12-21 00:00:00
abstract::After paralyzing spinal cord injury the adult nervous system has little ability to 'heal' spinal connections, and it is assumed to be unable to develop extra-spinal recovery strategies to bypass the lesion. We challenge this assumption, showing that completely spinalized adult rats can recover unassisted hindlimb weig...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23532
更新日期:2017-06-29 00:00:00
abstract::Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose availability or the energy sensor AMP-activat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51063
更新日期:2019-12-23 00:00:00
abstract::In Drosophila larvae, Class IV sensory neurons respond to noxious thermal stimuli and provoke heat avoidance behavior. Previously, we showed that the activated neurons displayed characteristic fluctuations of firing rates, which consisted of repetitive high-frequency spike trains and subsequent pause periods, and we p...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.29754
更新日期:2017-10-16 00:00:00
abstract::During early embryogenesis, cells must exit pluripotency and commit to multiple lineages in all germ-layers. How this transition is operated in vivo is poorly understood. Here, we report that MEK1 and the Nanog-related transcription factor Ventx2 coordinate this transition. MEK1 was required to make Xenopus pluripoten...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21526
更新日期:2017-06-27 00:00:00
abstract::Pathological metabolic conditions such as ischemia induce the rupture of the mitochondrial envelope and the release of pro-apoptotic proteins, leading to cell death. At the onset of this process, the inner mitochondrial membrane becomes depolarized and permeable to osmolytes, proposedly due to the opening of a non-sel...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23781
更新日期:2017-02-10 00:00:00
abstract::In plants the dorsoventral boundary of leaves defines an axis of symmetry through the centre of the organ separating the top (dorsal) and bottom (ventral) tissues. Although the positioning of this boundary is critical for leaf morphogenesis, how the boundary is established and how it influences development remains unc...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27421
更新日期:2017-09-12 00:00:00
abstract::Understanding how virus capsids assemble around their nucleic acid (NA) genomes could promote efforts to block viral propagation or to reengineer capsids for gene therapy applications. We develop a coarse-grained model of capsid proteins and NAs with which we investigate assembly dynamics and thermodynamics. In contra...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00632
更新日期:2013-06-14 00:00:00
abstract::Auditory processing depends upon inhibitory signaling by interneurons, even at its earliest stages in the ventral cochlear nucleus (VCN). Remarkably, to date only a single subtype of inhibitory neuron has been documented in the VCN, a projection neuron termed the D-stellate cell. With the use of a transgenic mouse lin...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54350
更新日期:2020-11-03 00:00:00
abstract::We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture pas...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58042
更新日期:2020-08-24 00:00:00
abstract::Direct activation of the human phospholipase C-γ isozymes (PLC-γ1, -γ2) by tyrosine phosphorylation is fundamental to the control of diverse biological processes, including chemotaxis, platelet aggregation, and adaptive immunity. In turn, aberrant activation of PLC-γ1 and PLC-γ2 is implicated in inflammation, autoimmu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51700
更新日期:2019-12-31 00:00:00
abstract::A major puzzle in biology is how mammalian sperm maintain the correct swimming direction during various phases of the sexual reproduction process. Whilst chemotaxis may dominate near the ovum, it is unclear which cues guide spermatozoa on their long journey towards the egg. Hypothesized mechanisms range from peristalt...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02403
更新日期:2014-05-27 00:00:00
abstract::Positive-strand RNA viruses, the largest genetic class of viruses, include numerous important pathogens such as Zika virus. These viruses replicate their RNA genomes in novel, membrane-bounded mini-organelles, but the organization of viral proteins and RNAs in these compartments has been largely unknown. We used cryo-...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25940
更新日期:2017-06-27 00:00:00
abstract::Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development. Here, we report endocytic sorting signals for the receptor Patched1 (Ptch1), comprising two 'PPXY' motifs, that direct it to degra...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02555
更新日期:2014-06-12 00:00:00