Effects of microcompartmentation on flux distribution and metabolic pools in Chlamydomonas reinhardtii chloroplasts.

abstract：:With implantation, mouse stromal cells begin to transform into epithelial-like cells surrounding the implantation chamber forming an avascular zone called the primary decidual zone (PDZ). In the mouse, the PDZ forms a transient, size-dependent permeable barrier to protect the embryo from maternal circulating harmful a...

journal_title：eLife

authors： Li Y,Dewar A,Kim YS,Dey SK,Sun X

更新日期：2020-09-29 00:00:00

abstract：:Orphans are genes restricted to a single phylogenetic lineage and emerge at high rates. While this predicts an accumulation of genes, the gene number has remained remarkably constant through evolution. This paradox has not yet been resolved. Because orphan genes have been mainly analyzed over long evolutionary time sc...

journal_title：eLife

authors： Palmieri N,Kosiol C,Schlötterer C

更新日期：2014-02-19 00:00:00

abstract：:MyD88 is the main adaptor molecule for TLR and IL-1R family members. Here, we demonstrated that T-cell intrinsic MyD88 signaling is required for proliferation, protection from apoptosis and expression of activation/memory genes during infection with the intracellular parasite Trypanosoma cruzi, as evidenced by transcr...

journal_title：eLife

authors： Oliveira AC,Gomes-Neto JF,Barbosa CD,Granato A,Reis BS,Santos BM,Fucs R,Canto FB,Nakaya HI,Nóbrega A,Bellio M

更新日期：2017-09-12 00:00:00

abstract：:Pattern completion, or the ability to retrieve stable neural activity patterns from noisy or partial cues, is a fundamental feature of memory. Theoretical studies indicate that recurrently connected auto-associative or discrete attractor networks can perform this process. Although pattern completion and attractor dyna...

journal_title：eLife

authors： Bolding KA,Nagappan S,Han BX,Wang F,Franks KM

更新日期：2020-07-14 00:00:00

abstract：:Cerebral cortical architecture at birth encodes regionally differential dendritic arborization and synaptic formation. It underlies behavioral emergence of 2-year-olds. Brain changes in 0-2 years are most dynamic across the lifespan. Effective prediction of future behavior with brain microstructure at birth will revea...

journal_title：eLife

authors： Ouyang M,Peng Q,Jeon T,Heyne R,Chalak L,Huang H

更新日期：2020-12-22 00:00:00

abstract：:In recent years, functional genomics approaches combining genetic information with bulk RNA-sequencing data have identified the downstream expression effects of disease-associated genetic risk factors through so-called expression quantitative trait locus (eQTL) analysis. Single-cell RNA-sequencing creates enormous opp...

journal_title：eLife

authors： van der Wijst M,de Vries DH,Groot HE,Trynka G,Hon CC,Bonder MJ,Stegle O,Nawijn MC,Idaghdour Y,van der Harst P,Ye CJ,Powell J,Theis FJ,Mahfouz A,Heinig M,Franke L

更新日期：2020-03-09 00:00:00

abstract：:Burkholderia thailandensis uses acyl-homoserine lactone-mediated quorum sensing systems to regulate hundreds of genes. Here we show that cell-cell contact-dependent type VI secretion (T6S) toxin-immunity systems are among those activated by quorum sensing in B. thailandensis. We also demonstrate that T6S is required t...

journal_title：eLife

authors： Majerczyk C,Schneider E,Greenberg EP

更新日期：2016-05-16 00:00:00

abstract：:Adhesion molecules hold cells together but also couple cell membranes to a contractile actomyosin network, which limits the expansion of cell contacts. Despite their fundamental role in tissue morphogenesis and tissue homeostasis, how adhesion molecules control cell shapes and cell patterns in tissues remains unclear....

journal_title：eLife

authors： Chan EH,Chavadimane Shivakumar P,Clément R,Laugier E,Lenne PF

更新日期：2017-05-24 00:00:00

abstract：:Cavin-3 regulates metabolism and cell proliferation by coordinating the activities of growth factor signalling cascades. ...

journal_title：eLife

authors： Whitmarsh AJ

更新日期：2013-09-24 00:00:00

abstract：:Purkinje neurons are central to cerebellar function and show membrane bistability when recorded in vitro or in vivo under anesthesia. The existence of bistability in vivo in awake animals is disputed. Here, by recording intracellularly from Purkinje neurons in unanesthetized larval zebrafish (Danio rerio), we unequivo...

journal_title：eLife

authors： Sengupta M,Thirumalai V

更新日期：2015-09-29 00:00:00

abstract：:The sequential activation of neurons has been observed in various areas of the brain, but in no case is the underlying network structure well understood. Here we examined the circuit anatomy of zebra finch HVC, a cortical region that generates sequences underlying the temporal progression of the song. We combined seri...

journal_title：eLife

authors： Kornfeld J,Benezra SE,Narayanan RT,Svara F,Egger R,Oberlaender M,Denk W,Long MA

更新日期：2017-03-27 00:00:00

abstract：:Atopic dermatitis can result from loss of structural proteins in the outermost epidermal layers, leading to a defective epidermal barrier. To test whether this influences tumour formation, we chemically induced tumours in EPI-/- mice, which lack three barrier proteins-Envoplakin, Periplakin, and Involucrin. EPI-/- mic...

journal_title：eLife

authors： Cipolat S,Hoste E,Natsuga K,Quist SR,Watt FM

更新日期：2014-05-05 00:00:00

abstract：:D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood. By virally expressing the isoforms in dopamine neurons of D2 receptor knockout mice, th...

journal_title：eLife

authors： Gantz SC,Robinson BG,Buck DC,Bunzow JR,Neve RL,Williams JT,Neve KA

更新日期：2015-08-26 00:00:00

abstract：:Rapid diagnostic tests (RDTs) have transformed malaria diagnosis. The most prevalent P. falciparum RDTs detect histidine-rich protein 2 (PfHRP2). However, pfhrp2 gene deletions yielding false-negative RDTs, first reported in South America in 2010, have been confirmed in Africa and Asia. We developed a mathematical mod...

journal_title：eLife

authors： Watson OJ,Slater HC,Verity R,Parr JB,Mwandagalirwa MK,Tshefu A,Meshnick SR,Ghani AC

更新日期：2017-08-24 00:00:00

abstract：:Learning to perform a complex motor task requires the optimization of specific behavioral features to cope with task constraints. We show that when mice learn a novel motor paradigm they differentially refine specific behavioral features. Animals trained to perform progressively faster sequences of lever presses to ob...

journal_title：eLife

authors： Santos FJ,Oliveira RF,Jin X,Costa RM

更新日期：2015-09-29 00:00:00

abstract：:The nematode Caenorhabditis elegans possesses a simple embryonic nervous system with few enough neurons that the growth of each cell could be followed to provide a systems-level view of development. However, studies of single cell development have largely been conducted in fixed or pre-twitching live embryos, because ...

journal_title：eLife

authors： Christensen RP,Bokinsky A,Santella A,Wu Y,Marquina-Solis J,Guo M,Kovacevic I,Kumar A,Winter PW,Tashakkori N,McCreedy E,Liu H,McAuliffe M,Mohler W,Colón-Ramos DA,Bao Z,Shroff H

更新日期：2015-12-03 00:00:00

abstract：:Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing. The importance of fast synaptic recruitment and action potential initiation and repolarization, and rapid synchronous GABA release by PV+ cells, is well ...

journal_title：eLife

authors： Cornford JH,Mercier MS,Leite M,Magloire V,Häusser M,Kullmann DM

更新日期：2019-10-28 00:00:00

abstract：:A major puzzle in biology is how mammalian sperm maintain the correct swimming direction during various phases of the sexual reproduction process. Whilst chemotaxis may dominate near the ovum, it is unclear which cues guide spermatozoa on their long journey towards the egg. Hypothesized mechanisms range from peristalt...

journal_title：eLife

authors： Kantsler V,Dunkel J,Blayney M,Goldstein RE

更新日期：2014-05-27 00:00:00

abstract：:The yeast Dsc E3 ligase complex has long been recognized as a Golgi-specific protein ubquitination system. It shares a striking sequence similarity to the Hrd1 complex that plays critical roles in the ER-associated degradation pathway. Using biochemical purification and mass spectrometry, we identified two novel Dsc s...

journal_title：eLife

authors： Yang X,Arines FM,Zhang W,Li M

更新日期：2018-01-22 00:00:00

abstract：:Experiments on mitochondrial DNA in worms highlight that cheating does not always pay off. ...

journal_title：eLife

authors： Camus MF

更新日期：2020-09-22 00:00:00

abstract：:Swi2/Snf2 ATPases remodel substrates such as nucleosomes and transcription complexes to control a wide range of DNA-associated processes, but detailed structural information on the ATP-dependent remodeling reactions is largely absent. The single subunit remodeler Mot1 (modifier of transcription 1) dissociates TATA box...

journal_title：eLife

authors： Butryn A,Schuller JM,Stoehr G,Runge-Wollmann P,Förster F,Auble DT,Hopfner KP

更新日期：2015-08-10 00:00:00

abstract：:Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling and cell division. We show that mechanical strain induced Src-depe...

journal_title：eLife

authors： Benham-Pyle BW,Sim JY,Hart KC,Pruitt BL,Nelson WJ

更新日期：2016-10-26 00:00:00

abstract：:The spinal cord has the capacity to coordinate motor activities such as locomotion. Following spinal transection, functional activity can be regained, to a degree, following motor training. To identify microcircuits involved in this recovery, we studied a population of mouse spinal interneurons known to receive direct...

journal_title：eLife

authors： Bui TV,Stifani N,Akay T,Brownstone RM

更新日期：2016-12-15 00:00:00

abstract：: ...

journal_title：eLife

authors： Hayasaka N,Hirano A,Miyoshi Y,Tokuda IT,Yoshitane H,Matsuda J,Fukada Y

更新日期：2021-01-25 00:00:00

abstract：:Actin, spectrin, and associated molecules form a periodic sub-membrane lattice structure in axons. How this membrane skeleton is developed and why it preferentially forms in axons are unknown. Here, we studied the developmental mechanism of this lattice structure. We found that this structure emerged early during axon...

journal_title：eLife

authors： Zhong G,He J,Zhou R,Lorenzo D,Babcock HP,Bennett V,Zhuang X

更新日期：2014-12-23 00:00:00

abstract：:Class IV ddaC neurons specifically prune larval dendrites without affecting axons during Drosophila metamorphosis. ddaCs distribute the minus ends of microtubules (MTs) to dendrites but the plus ends to axons. However, a requirement of MT minus-end-binding proteins in dendrite-specific pruning remains completely unkno...

journal_title：eLife

authors： Wang Y,Rui M,Tang Q,Bu S,Yu F

更新日期：2019-03-28 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely reflects the target cell of transformation rather than being required for continued tumor growt...

journal_title：eLife

authors： Tenente IM,Hayes MN,Ignatius MS,McCarthy K,Yohe M,Sindiri S,Gryder B,Oliveira ML,Ramakrishnan A,Tang Q,Chen EY,Petur Nielsen G,Khan J,Langenau DM

更新日期：2017-01-12 00:00:00

abstract：:The brain needs to predict how the body reacts to motor commands, but how a network of spiking neurons can learn non-linear body dynamics using local, online and stable learning rules is unclear. Here, we present a supervised learning scheme for the feedforward and recurrent connections in a network of heterogeneous s...

journal_title：eLife

authors： Gilra A,Gerstner W

更新日期：2017-11-27 00:00:00

abstract：:Certain neuron types fire spontaneously at high rates, an ability that is crucial for their function in brain circuits. The spontaneously active GABAergic neurons of the substantia nigra pars reticulata (SNr), a major output of the basal ganglia, provide tonic inhibition of downstream brain areas. A depolarizing 'leak...

journal_title：eLife

authors： Lutas A,Lahmann C,Soumillon M,Yellen G

更新日期：2016-05-13 00:00:00

abstract：:Recent studies suggested an essential role for seryl-tRNA synthetase (SerRS) in vascular development. This role is specific to SerRS among all tRNA synthetases and is independent of its well-known aminoacylation function in protein synthesis. A unique nucleus-directing domain, added at the invertebrate-to-vertebrate t...

journal_title：eLife

authors： Shi Y,Xu X,Zhang Q,Fu G,Mo Z,Wang GS,Kishi S,Yang XL

更新日期：2014-06-17 00:00:00