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eLife文献大全abstract::The orbitofrontal cortex (OFC) is critical for updating reward-directed behaviours flexibly when outcomes are devalued or when task contingencies are reversed. Failure to update behaviour in outcome devaluation and reversal learning procedures are considered canonical deficits following OFC lesions in non-human primat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37357
更新日期:2018-07-25 00:00:00
abstract::During development, tissue repair, and tumor growth, most blood vessel networks are generated through angiogenesis. Vascular endothelial growth factor (VEGF) is a key regulator of this process and currently both VEGF and its receptors, VEGFR1, VEGFR2, and Neuropilin1 (NRP1), are targeted in therapeutic strategies for ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03720
更新日期:2014-09-22 00:00:00
abstract::The axolotl can regenerate multiple organs, including the brain. It remains, however, unclear whether neuronal diversity, intricate tissue architecture, and axonal connectivity can be regenerated; yet, this is critical for recovery of function and a central aim of cell replacement strategies in the mammalian central n...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.13998
更新日期:2016-05-09 00:00:00
abstract::Circadian rhythms are biological oscillations that schedule daily changes in physiology. Outside the laboratory, circadian clocks do not generally free-run but are driven by daily cues whose timing varies with the seasons. The principles that determine how circadian clocks align to these external cycles are not well u...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23539
更新日期:2017-07-07 00:00:00
abstract::Disruption of the sumoylation/desumoylation equilibrium is associated with several disease states such as cancer and infections, however the mechanisms regulating the global SUMO balance remain poorly defined. Here, we show that infection by Shigella flexneri, the causative agent of human bacillary dysentery, switches...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27444
更新日期:2017-12-12 00:00:00
abstract::This study examined records of 2566 consecutive COVID-19 patients at five Massachusetts hospitals and sought to predict level-of-care requirements based on clinical and laboratory data. Several classification methods were applied and compared against standard pneumonia severity scores. The need for hospitalization, IC...
journal_title:eLife
pub_type: 杂志文章,多中心研究
doi:10.7554/eLife.60519
更新日期:2020-10-12 00:00:00
abstract::Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelle...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25014
更新日期:2017-06-30 00:00:00
abstract::Brain connectivity maps display a delicate balance between individual variation and stereotypy, suggesting the existence of dedicated mechanisms that simultaneously permit and limit individual variation. We show that during the development of the Drosophila central nervous system, mutual inhibition among groups of nei...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00337
更新日期:2013-03-05 00:00:00
abstract::Neural computations underlying cognitive functions require calibration of the strength of excitatory and inhibitory synaptic connections and are associated with modulation of gamma frequency oscillations in network activity. However, principles relating gamma oscillations, synaptic strength and circuit computations ar...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.06444
更新日期:2015-07-06 00:00:00
abstract::The non-canonical Wnt/Ca2+ signaling pathway plays important roles in embryonic development, tissue formation and diseases. However, it is unclear how the Wnt ligand-stimulated, G protein-coupled receptor Frizzled activates phospholipases for calcium release. Here, we report that the zebrafish/human phosphatidylinosit...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26362
更新日期:2017-05-02 00:00:00
abstract::Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune system. Here we report ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34890
更新日期:2018-07-11 00:00:00
abstract::We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were foun...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.15175
更新日期:2016-07-15 00:00:00
abstract::In order to assess the contribution of a central clock in the hypothalamic suprachiasmatic nucleus (SCN) to circadian behavior and the organization of peripheral clocks, we generated forebrain/SCN-specific Bmal1 knockout mice by using floxed Bmal1 and pan-neuronal Cre lines. The forebrain knockout mice showed >90% del...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04617
更新日期:2014-12-19 00:00:00
abstract::Combining clonal analysis with a computational agent based model, we investigate how tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE) of the teleost medaka (Oryzias latipes) coordinate their growth rates. NR cell division timing is less variable, consistent with an upstream role...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.42646
更新日期:2019-03-26 00:00:00
abstract::Tuberculosis disproportionately affects the Canadian Inuit. To address this, it is imperative we understand transmission dynamics in this population. We investigate whether 'deep' sequencing can provide additional resolution compared to standard sequencing, using a well-characterized outbreak from the Arctic (2011-201...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53245
更新日期:2020-02-04 00:00:00
abstract::IQ scores are correlated with the morphology and activity of certain neurons in the human temporal cortex. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.44560
更新日期:2019-02-05 00:00:00
abstract::Animals seek out relevant information by moving through a dynamic world, but sensory systems are usually studied under highly constrained and passive conditions that may not probe important dimensions of the neural code. Here, we explored neural coding in the barrel cortex of head-fixed mice that tracked walls with th...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12559
更新日期:2015-12-23 00:00:00
abstract::Malaria infection starts with injection of Plasmodium sporozoites by an Anopheles mosquito into the skin of the mammalian host. How sporozoites locate and enter a blood vessel is a critical, but poorly understood process. In this study, we examine sporozoite motility and their interaction with dermal blood vessels, us...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.07789
更新日期:2015-08-13 00:00:00
abstract::As the demographics of the modern world skew older, understanding and mitigating the effects of aging is increasingly important within biomedical research. Recent studies in model organisms demonstrate that the aging process is frequently modified by an organism's ability to perceive and respond to changes in its envi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.62659
更新日期:2020-12-10 00:00:00
abstract::Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, Perforin-2 prevents the intracellular replication and proliferation of bacterial pathogens in these cells. Perfori...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.06508
更新日期:2015-09-24 00:00:00
abstract::Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear. We found that PTBP1 binding in the flanking introns allowed normal U2AF and U1 sn...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.19743
更新日期:2016-11-24 00:00:00
abstract::How living systems break symmetry in an organized manner is a fundamental question in biology. In wild-type Caenorhabditis elegans zygotes, symmetry breaking during anterior-posterior axis specification is guided by centrosomes, resulting in anterior-directed cortical flows and a single posterior PAR-2 domain. We unco...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44552
更新日期:2019-02-26 00:00:00
abstract::Repression of genes by Polycomb requires that PRC2 modifies their chromatin by trimethylating lysine 27 on histone H3 (H3K27me3). At transcriptionally active genes, di- and tri-methylated H3K36 inhibit PRC2. Here, the cryo-EM structure of PRC2 on dinucleosomes reveals how binding of its catalytic subunit EZH2 to nucle...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.61964
更新日期:2020-11-19 00:00:00
abstract::Whether somatic mutations contribute functional diversity to brain cells is a long-standing question. Single-neuron genomics enables direct measurement of somatic mutation rates in human brain and promises to answer this question. A recent study (Upton et al., 2015) reported high rates of somatic LINE-1 element (L1) r...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12966
更新日期:2016-02-22 00:00:00
abstract::The palmitoyl acyltransferase (PAT) ZDHHC14 is highly expressed in the hippocampus and is the only PAT predicted to bind Type-I PDZ domain-containing proteins. However, ZDHHC14's neuronal roles are unknown. Here, we identify the PDZ domain-containing Membrane-associated Guanylate Kinase (MaGUK) PSD93 as a direct ZDHHC...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56058
更新日期:2020-11-13 00:00:00
abstract::bicoid mRNA localises to the Drosophila oocyte anterior from stage 9 of oogenesis onwards to provide a local source for Bicoid protein for embryonic patterning. Live imaging at stage 9 reveals that bicoid mRNA particles undergo rapid Dynein-dependent movements near the oocyte anterior, but with no directional bias. Fu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.17537
更新日期:2016-10-28 00:00:00
abstract::The IFNλ family of interferons controls the spread of viruses in the upper respiratory tract and transmission between mice. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.37552
更新日期:2018-05-24 00:00:00
abstract::Experience-dependent modifications of synaptic connections are thought to change patterns of network activities and stimulus tuning with learning. However, only a few studies explored how synaptic plasticity shapes the response dynamics of cortical circuits. Here, we investigated the mechanism underlying sharpening of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44098
更新日期:2019-08-08 00:00:00
abstract::One of the major unanswered questions in evolutionary biology is when and how the transition between diderm (two membranes) and monoderm (one membrane) cell envelopes occurred in Bacteria. The Negativicutes and the Halanaerobiales belong to the classically monoderm Firmicutes, but possess outer membranes with lipopoly...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14589
更新日期:2016-08-31 00:00:00
abstract::Although the wiring of the cerebellar cortex appears to be uniform, the neurons in this region of the brain behave more differently from each other than previously thought. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.03285
更新日期:2014-06-10 00:00:00