Abstract:
:This study examined records of 2566 consecutive COVID-19 patients at five Massachusetts hospitals and sought to predict level-of-care requirements based on clinical and laboratory data. Several classification methods were applied and compared against standard pneumonia severity scores. The need for hospitalization, ICU care, and mechanical ventilation were predicted with a validation accuracy of 88%, 87%, and 86%, respectively. Pneumonia severity scores achieve respective accuracies of 73% and 74% for ICU care and ventilation. When predictions are limited to patients with more complex disease, the accuracy of the ICU and ventilation prediction models achieved accuracy of 83% and 82%, respectively. Vital signs, age, BMI, dyspnea, and comorbidities were the most important predictors of hospitalization. Opacities on chest imaging, age, admission vital signs and symptoms, male gender, admission laboratory results, and diabetes were the most important risk factors for ICU admission and mechanical ventilation. The factors identified collectively form a signature of the novel COVID-19 disease. :The new coronavirus (now named SARS-CoV-2) causing the disease pandemic in 2019 (COVID-19), has so far infected over 35 million people worldwide and killed more than 1 million. Most people with COVID-19 have no symptoms or only mild symptoms. But some become seriously ill and need hospitalization. The sickest are admitted to an Intensive Care Unit (ICU) and may need mechanical ventilation to help them breath. Being able to predict which patients with COVID-19 will become severely ill could help hospitals around the world manage the huge influx of patients caused by the pandemic and save lives. Now, Hao, Sotudian, Wang, Xu et al. show that computer models using artificial intelligence technology can help predict which COVID-19 patients will be hospitalized, admitted to the ICU, or need mechanical ventilation. Using data of 2,566 COVID-19 patients from five Massachusetts hospitals, Hao et al. created three separate models that can predict hospitalization, ICU admission, and the need for mechanical ventilation with more than 86% accuracy, based on patient characteristics, clinical symptoms, laboratory results and chest x-rays. Hao et al. found that the patients’ vital signs, age, obesity, difficulty breathing, and underlying diseases like diabetes, were the strongest predictors of the need for hospitalization. Being male, having diabetes, cloudy chest x-rays, and certain laboratory results were the most important risk factors for intensive care treatment and mechanical ventilation. Laboratory results suggesting tissue damage, severe inflammation or oxygen deprivation in the body's tissues were important warning signs of severe disease. The results provide a more detailed picture of the patients who are likely to suffer from severe forms of COVID-19. Using the predictive models may help physicians identify patients who appear okay but need closer monitoring and more aggressive treatment. The models may also help policy makers decide who needs workplace accommodations such as being allowed to work from home, which individuals may benefit from more frequent testing, and who should be prioritized for vaccination when a vaccine becomes available.
journal_name
Elifejournal_title
eLifeauthors
Hao B,Sotudian S,Wang T,Xu T,Hu Y,Gaitanidis A,Breen K,Velmahos GC,Paschalidis ICdoi
10.7554/eLife.60519subject
Has Abstractpub_date
2020-10-12 00:00:00issn
2050-084Xpii
60519journal_volume
9pub_type
杂志文章,多中心研究相关文献
eLife文献大全abstract::When a human catches a ball, they estimate future target location based on the current trajectory. How animals, small and large, encode such predictive processes at the single neuron level is unknown. Here we describe small target-selective neurons in predatory dragonflies that exhibit localized enhanced sensitivity f...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26478
更新日期:2017-07-25 00:00:00
abstract::Hepatitis B virus (HBV) is an important but difficult to study human pathogen. Most basics of the hepadnaviral life-cycle were unraveled using duck HBV (DHBV) as a model although DHBV has a capsid protein (CP) comprising ~260 rather than ~180 amino acids. Here we present high-resolution structures of several DHBV caps...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57277
更新日期:2020-08-14 00:00:00
abstract::Precise and efficient manipulation of genes is crucial for understanding the molecular mechanisms that govern human hematopoiesis and for developing novel therapies for diseases of the blood and immune system. Current methods do not enable precise engineering of complex genotypes that can be easily tracked in a mixed ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27873
更新日期:2017-09-28 00:00:00
abstract::A small transparent crustacean called Parhyale hawaiensis has become a powerful model system for the study of limb and appendage regeneration. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.21583
更新日期:2016-10-25 00:00:00
abstract::Experience-dependent modifications of synaptic connections are thought to change patterns of network activities and stimulus tuning with learning. However, only a few studies explored how synaptic plasticity shapes the response dynamics of cortical circuits. Here, we investigated the mechanism underlying sharpening of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44098
更新日期:2019-08-08 00:00:00
abstract::To move the body, the brain must precisely coordinate patterns of activity among diverse populations of motor neurons. Here, we use in vivo calcium imaging, electrophysiology, and behavior to understand how genetically-identified motor neurons control flexion of the fruit fly tibia. We find that leg motor neurons exhi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56754
更新日期:2020-06-03 00:00:00
abstract::During development, tissue repair, and tumor growth, most blood vessel networks are generated through angiogenesis. Vascular endothelial growth factor (VEGF) is a key regulator of this process and currently both VEGF and its receptors, VEGFR1, VEGFR2, and Neuropilin1 (NRP1), are targeted in therapeutic strategies for ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03720
更新日期:2014-09-22 00:00:00
abstract::Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of the spinal cord. How a neural stem cell under homeostasis converts after injury to a highly regenerative cell remains unknown. Here, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and rea...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10230
更新日期:2015-11-14 00:00:00
abstract::Imaging sperm as they travel through the female reproductive tract has revealed new details about fertilization at the molecular level. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.64379
更新日期:2020-12-02 00:00:00
abstract::The gut microbiota of patients recently diagnosed with rheumatoid arthritis is enriched in microbes belonging to the Prevotella genus. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.01608
更新日期:2013-11-05 00:00:00
abstract::Journals and other scientific organizations produce a diverse variety of plain-language summaries. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25411
更新日期:2017-03-15 00:00:00
abstract::Pathological metabolic conditions such as ischemia induce the rupture of the mitochondrial envelope and the release of pro-apoptotic proteins, leading to cell death. At the onset of this process, the inner mitochondrial membrane becomes depolarized and permeable to osmolytes, proposedly due to the opening of a non-sel...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23781
更新日期:2017-02-10 00:00:00
abstract::Sudden changes in the level of a coenzyme called NADPH might be the underlying cause of aging in cells. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00515
更新日期:2013-02-05 00:00:00
abstract::Multiple studies have reported a male bias in incidence and/or prevalence of malaria infection in males compared to females. To test the hypothesis that sex-based differences in host-parasite interactions affect the epidemiology of malaria, we intensively followed Plasmodium falciparum infections in a cohort in a mala...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59872
更新日期:2020-10-27 00:00:00
abstract::Most evolutionary thinking is based on the notion of fitness and related ideas such as fitness landscapes and evolutionary optima. Nevertheless, it is often unclear what fitness actually is, and its meaning often depends on the context. Here we argue that fitness should not be a basal ingredient in verbal or mathemati...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23804
更新日期:2017-02-15 00:00:00
abstract::Regulation of protein turnover allows cells to react to their environment and maintain homeostasis. Proteins can show different turnover rates in different tissue, but little is known about protein turnover in different brain cell types. We used dynamic SILAC to determine half-lives of over 5100 proteins in rat primar...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34202
更新日期:2018-06-19 00:00:00
abstract::As the equipment needed to perform state-of-the-art research in many areas of biology becomes ever more expensive, Eve Marder worries that researchers in less wealthy institutions might be left behind. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01515
更新日期:2013-11-19 00:00:00
abstract::Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule cells (GCs). Sema5A is strongly expressed by GCs and regulates d...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04390
更新日期:2014-10-14 00:00:00
abstract::Pancreatic ATP-sensitive K+ channels (KATP) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts KATP. Mg-nucleotide binding to SUR1 stimulates KATP. In the absence of Mg2+, SUR1 increases the apparent affinity for nucleotide inhibition...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52775
更新日期:2020-01-07 00:00:00
abstract::The neural control of transition between posture and movement encompasses the regulation of reflex-stabilizing mechanisms to enable motion. Optimal feedback theory suggests that such transitions require the disengagement of one motor control policy before the implementation of another. To test this possibility, we inv...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36123
更新日期:2018-07-10 00:00:00
abstract::Nutritional regulation by ants emerges from a distributed process: food is collected by a small fraction of workers, stored within the crops of individuals, and spread via local ant-to-ant interactions. The precise individual-level underpinnings of this collective regulation have remained unclear mainly due to difficu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.31730
更新日期:2018-03-06 00:00:00
abstract::Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that degrades aberrant mRNAs and also regulates the expression of a wide range of physiological transcripts. RUVBL1 and RUVBL2 AAA-ATPases form an hetero-hexameric ring that is part of several macromolecular complexes such as INO80, SWR1, and R2TP. Interesti...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.63042
更新日期:2020-11-18 00:00:00
abstract::Nervous systems distinguish between self- and other-generated movements by monitoring discrepancies between planned and performed actions. To do so, corollary discharges are conveyed to sensory areas and gate expected reafference. Such gating is observed in neonatal rats during wake-related movements. In contrast, twi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18749
更新日期:2016-08-03 00:00:00
abstract::Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1 channels, which are mechanically-activated non-selective cation channels. In cultured microvascular endothelial cells, Piezo1 channel activation by either shear...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50684
更新日期:2020-06-02 00:00:00
abstract::While the dynamin GTPase Drp1 plays a critical role during mitochondrial fission, mechanisms controlling its recruitment to fission sites are unclear. A current assumption is that cytosolic Drp1 is recruited directly to fission sites immediately prior to fission. Using live-cell microscopy, we find evidence for a diff...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11553
更新日期:2015-11-26 00:00:00
abstract::Telomeres are nucleoprotein complexes at the ends of chromosomes and are indispensable for the protection and lengthening of terminal DNA. Despite the evolutionarily conserved roles of telomeres, the telomeric double-strand DNA (dsDNA)-binding proteins have evolved rapidly. Here, we identified double-strand telomeric ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.64104
更新日期:2021-01-21 00:00:00
abstract::Sleep oscillations in the neocortex and hippocampus are critical for the integration of new memories into stable generalized representations in neocortex. However, the role of the thalamus in this process is poorly understood. To determine the thalamic contribution to non-REM oscillations (sharp-wave ripples, SWRs; sl...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.48881
更新日期:2020-06-11 00:00:00
abstract::WNK1, a kinase that controls kidney salt homeostasis, also regulates adhesion and migration in CD4+ T cells. Wnk1 is highly expressed in thymocytes, and since migration is important for thymocyte maturation, we investigated a role for WNK1 in mouse thymocyte development. We find that WNK1 is required for the transitio...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56934
更新日期:2020-10-14 00:00:00
abstract::Aedes aegypti transmit pathogenic arboviruses while the mosquito itself tolerates the infection. We examine a piRNA-based immunity that relies on the acquisition of viral derived cDNA (vDNA) and how this pathway discriminates between self and non-self. The piRNAs derived from these vDNAs are essential for virus contro...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.41244
更新日期:2019-10-17 00:00:00
abstract::Methyl-coenzyme M reductase (MCR), found in strictly anaerobic methanogenic and methanotrophic archaea, catalyzes the reversible production and consumption of the potent greenhouse gas methane. The α subunit of MCR (McrA) contains several unusual post-translational modifications, including a rare thioamidation of glyc...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.29218
更新日期:2017-09-07 00:00:00