Abstract:
:Sudden changes in the level of a coenzyme called NADPH might be the underlying cause of aging in cells.
journal_name
Elifejournal_title
eLifeauthors
Barral Ydoi
10.7554/eLife.00515subject
Has Abstractpub_date
2013-02-05 00:00:00pages
e00515issn
2050-084Xpii
00515journal_volume
2pub_type
杂志文章相关文献
eLife文献大全abstract::Early life adversity (ELA) is associated with increased risk for stress-related disorders later in life. The link between ELA and risk for psychopathology is well established but the developmental mechanisms remain unclear. Using a mouse model of resource insecurity, limited bedding (LB), we tested the effects of LB o...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55263
更新日期:2020-07-21 00:00:00
abstract::During inflammation, serum amyloid A proteins transport retinol to infected tissues. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.04246
更新日期:2014-09-02 00:00:00
abstract::Hepatitis B virus (HBV) is an important but difficult to study human pathogen. Most basics of the hepadnaviral life-cycle were unraveled using duck HBV (DHBV) as a model although DHBV has a capsid protein (CP) comprising ~260 rather than ~180 amino acids. Here we present high-resolution structures of several DHBV caps...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57277
更新日期:2020-08-14 00:00:00
abstract::WNK1, a kinase that controls kidney salt homeostasis, also regulates adhesion and migration in CD4+ T cells. Wnk1 is highly expressed in thymocytes, and since migration is important for thymocyte maturation, we investigated a role for WNK1 in mouse thymocyte development. We find that WNK1 is required for the transitio...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56934
更新日期:2020-10-14 00:00:00
abstract::Research on mutant tobacco plants shows that a pigment called β-carotene is not necessary for photosynthesis. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.63584
更新日期:2020-11-03 00:00:00
abstract::Aeromonas bacteria living in the gut of zebrafish produce a specific molecule to pacify the immune system of their host. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.42676
更新日期:2018-11-06 00:00:00
abstract::With implantation, mouse stromal cells begin to transform into epithelial-like cells surrounding the implantation chamber forming an avascular zone called the primary decidual zone (PDZ). In the mouse, the PDZ forms a transient, size-dependent permeable barrier to protect the embryo from maternal circulating harmful a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.61762
更新日期:2020-09-29 00:00:00
abstract::Experiments in which monkeys have to select or estimate the location of a target are revealing more about the role of the dorsal premotor cortex in decision making. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.18721
更新日期:2016-07-15 00:00:00
abstract::Heritable variation in gene expression forms a crucial bridge between genomic variation and the biology of many traits. However, most expression quantitative trait loci (eQTLs) remain unidentified. We mapped eQTLs by transcriptome sequencing in 1012 yeast segregants. The resulting eQTLs accounted for over 70% of the h...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35471
更新日期:2018-07-17 00:00:00
abstract::Myelin, made by oligodendrocytes, is essential for rapid information transfer in the central nervous system. Oligodendrocyte precursors (OPs) receive glutamatergic synaptic input from axons but how this affects their development is unclear. Murine OPs in white matter express AMPA receptor (AMPAR) subunits GluA2, GluA3...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.28080
更新日期:2017-06-13 00:00:00
abstract::Our understanding of nonlinear stimulus transformations by neural circuits is hindered by the lack of comprehensive yet interpretable computational modeling frameworks. Here, we propose a data-driven approach based on deep neural networks to directly model arbitrarily nonlinear stimulus-response mappings. Reformulatin...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53445
更新日期:2020-06-26 00:00:00
abstract::The receptor protein Dectin-1 recognizes structures found on cancerous cells, and then triggers an anti-tumor immune response. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.04476
更新日期:2014-09-24 00:00:00
abstract::In eukaryotes, most integral membrane proteins are synthesized, integrated into the membrane, and folded properly in the endoplasmic reticulum (ER). We screened the mutants affecting rhabdomeric expression of rhodopsin 1 (Rh1) in the Drosophila photoreceptors and found that dPob/EMC3, EMC1, and EMC8/9, Drosophila homo...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.06306
更新日期:2015-02-26 00:00:00
abstract::IRE1α is an endoplasmic reticulum (ER) localized endonuclease activated by misfolded proteins in the ER. Previously, we demonstrated that IRE1α forms a complex with the Sec61 translocon, to which its substrate XBP1u mRNA is recruited for cleavage during ER stress (Plumb et al., 2015). Here, we probe IRE1α complexes in...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27187
更新日期:2017-05-15 00:00:00
abstract::Visual perception and behavior are mediated by cortical areas that have been distinguished using architectonic and retinotopic criteria. We employed fluorescence imaging and GCaMP6 reporter mice to generate retinotopic maps, revealing additional regions of retinotopic organization that extend into barrel and retrosple...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18372
更新日期:2017-01-06 00:00:00
abstract::Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia affecting geographically distant populations of two species of mussels (Mytilus chilensis in South America and M. edulis in Eur...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47788
更新日期:2019-11-05 00:00:00
abstract::Computational modeling of behavior has revolutionized psychology and neuroscience. By fitting models to experimental data we can probe the algorithms underlying behavior, find neural correlates of computational variables and better understand the effects of drugs, illness and interventions. But with great power comes ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49547
更新日期:2019-11-26 00:00:00
abstract::How circuits assemble starting from stem cells is a fundamental question in developmental neurobiology. We test the hypothesis that, in neuronal stem cells, temporal transcription factors predictably control neuronal terminal features and circuit assembly. Using the Drosophila motor system, we manipulate expression of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46089
更新日期:2019-09-10 00:00:00
abstract::A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here, we provide evidence that pericentromeric satellite DNA, which is often regarde...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34122
更新日期:2018-03-26 00:00:00
abstract::Aberrant expression of cancer genes and non-canonical RNA species is a hallmark of cancer. However, the mechanisms driving such atypical gene expression programs are incompletely understood. Here, our transcriptional profiling of a cohort of 50 primary clear cell renal cell carcinoma (ccRCC) samples from The Cancer Ge...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09214
更新日期:2015-11-17 00:00:00
abstract::Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis. Ndst1+ OLG ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51735
更新日期:2020-06-09 00:00:00
abstract::Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies. Here, we demonstrate engineering of electrically and chemically responsive, contractile human muscle tissues ('myobundles') using primar...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04885
更新日期:2015-01-09 00:00:00
abstract::Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of the whole cortex bas...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35237
更新日期:2018-05-11 00:00:00
abstract::Stem cells are maintained in a specialized microenvironment called niche but the nature of stem cell niche remains poorly defined in many systems. Here we demonstrate that intestinal epithelium-derived BMP serves as a niche signal for intestinal stem cell (ISC) self-renewal in Drosophila adult midgut. We find that BMP...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01857
更新日期:2014-03-11 00:00:00
abstract::A key hallmark of visual perceptual awareness is robustness to instabilities arising from unnoticeable eye and eyelid movements. In previous human intracranial (iEEG) work (Golan et al., 2016) we found that excitatory broadband high-frequency activity transients, driven by eye blinks, are suppressed in higher-level bu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27819
更新日期:2017-08-29 00:00:00
abstract::The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD225 family and inhibit diverse virus infections. IFITM3 reduces membrane fusion between cells and virions through a poorly characterized mechanism. Mutation of proline-rich transmembrane protein 2 (PRRT2), a regulator of neurotransmitter ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58537
更新日期:2020-10-28 00:00:00
abstract::Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage. Here, we examine the impact of brief periods of sleep deprivation on dendritic structure. In mice, we find that five hours o...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.13424
更新日期:2016-08-23 00:00:00
abstract::Macrophage-mediated phagocytosis and cytokine production represent the front lines of resistance to bacterial invaders. A key feature of this pro-inflammatory response in mammals is the complex remodeling of cellular metabolism towards aerobic glycolysis. Although the function of bactericidal macrophages is highly con...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50414
更新日期:2019-10-14 00:00:00
abstract::Axons span extreme distances and are subject to significant stretch deformations during limb movements or sudden head movements, especially during impacts. Yet, axon biomechanics, and its relation to the ultrastructure that allows axons to withstand mechanical stress, is poorly understood. Using a custom developed for...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51772
更新日期:2020-04-08 00:00:00
abstract::Initiatives to improve research communication can benefit from listening to graduate students, postdocs and newly-independent group leaders. ...
journal_title:eLife
pub_type: 社论
doi:10.7554/eLife.36263
更新日期:2018-03-27 00:00:00