Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.

Abstract:

:Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule cells (GCs). Sema5A is strongly expressed by GCs and regulates dendritic spine density in a cell-autonomous manner. In the adult mouse brain, newly born Sema5A-/- GCs show an increase in dendritic spine density and increased AMPA-type synaptic responses. Sema5A signals through PlexinA2 co-expressed by GCs, and the PlexinA2-RasGAP activity is necessary to suppress spinogenesis. Like Sema5A-/- mutants, PlexinA2-/- mice show an increase in GC glutamatergic synapses, and we show that Sema5A and PlexinA2 genetically interact with respect to GC spine phenotypes. Sema5A-/- mice display deficits in social interaction, a hallmark of autism-spectrum-disorders. These experiments identify novel intra-dendritic Sema5A/PlexinA2 interactions that inhibit excitatory synapse formation in developmentally born and adult-born GCs, and they provide support for SEMA5A contributions to autism-spectrum-disorders.

journal_name

Elife

journal_title

eLife

authors

Duan Y,Wang SH,Song J,Mironova Y,Ming GL,Kolodkin AL,Giger RJ

doi

10.7554/eLife.04390

subject

Has Abstract

pub_date

2014-10-14 00:00:00

issn

2050-084X

journal_volume

3

pub_type

杂志文章

相关文献

eLife文献大全
  • Impaired voice processing in reward and salience circuits predicts social communication in children with autism.

    abstract::Engaging with vocal sounds is critical for children's social-emotional learning, and children with autism spectrum disorder (ASD) often 'tune out' voices in their environment. Little is known regarding the neurobiological basis of voice processing and its link to social impairments in ASD. Here, we perform the first c...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.39906

    authors: Abrams DA,Padmanabhan A,Chen T,Odriozola P,Baker AE,Kochalka J,Phillips JM,Menon V

    更新日期:2019-02-26 00:00:00

  • Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion.

    abstract::Cytomegaloviruses (CMVs) are ubiquitous pathogens known to employ numerous immunoevasive strategies that significantly impair the ability of the immune system to eliminate the infected cells. Here, we report that the single mouse CMV (MCMV) protein, m154, downregulates multiple surface molecules involved in the activa...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.50803

    authors: Strazic Geljic I,Kucan Brlic P,Angulo G,Brizic I,Lisnic B,Jenus T,Juranic Lisnic V,Pietri GP,Engel P,Kaynan N,Zeleznjak J,Schu P,Mandelboim O,Krmpotic A,Angulo A,Jonjic S,Lenac Rovis T

    更新日期:2020-01-13 00:00:00

  • Tissue-autonomous immune response regulates stress signalling during hypertrophy.

    abstract::Postmitotic tissues are incapable of replacing damaged cells through proliferation, but need to rely on buffering mechanisms to prevent tissue disintegration. By constitutively activating the Ras/MAPK-pathway via RasV12-overexpression in the postmitotic salivary glands of Drosophila larvae, we overrode the glands adap...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.64919

    authors: Krautz R,Khalili D,Theopold U

    更新日期:2020-12-30 00:00:00

  • Surface color and predictability determine contextual modulation of V1 firing and gamma oscillations.

    abstract::The integration of direct bottom-up inputs with contextual information is a core feature of neocortical circuits. In area V1, neurons may reduce their firing rates when their receptive field input can be predicted by spatial context. Gamma-synchronized (30-80 Hz) firing may provide a complementary signal to rates, ref...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.42101

    authors: Peter A,Uran C,Klon-Lipok J,Roese R,van Stijn S,Barnes W,Dowdall JR,Singer W,Fries P,Vinck M

    更新日期:2019-02-04 00:00:00

  • Learning is enhanced by tailoring instruction to individual genetic differences.

    abstract::It is widely argued that personalized instruction based on individual differences in learning styles or genetic predispositions could improve learning outcomes. However, this proposition has resisted clear demonstration in human studies, where it is difficult to control experience and quantify outcomes. Here, we take ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.47216

    authors: Mets DG,Brainard MS

    更新日期:2019-09-17 00:00:00

  • Uncovering the functional anatomy of the human insula during speech.

    abstract::The contribution of insular cortex to speech production remains unclear and controversial given diverse findings from functional neuroimaging and lesional data. To create a precise spatiotemporal map of insular activity, we performed a series of experiments: single-word articulations of varying complexity, non-speech ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.53086

    authors: Woolnough O,Forseth KJ,Rollo PS,Tandon N

    更新日期:2019-12-19 00:00:00

  • Probe-Seq enables transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation.

    abstract::Recent transcriptional profiling technologies are uncovering previously-undefined cell populations and molecular markers at an unprecedented pace. While single cell RNA (scRNA) sequencing is an attractive approach for unbiased transcriptional profiling of all cell types, a complementary method to isolate and sequence ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.51452

    authors: Amamoto R,Garcia MD,West ER,Choi J,Lapan SW,Lane EA,Perrimon N,Cepko CL

    更新日期:2019-12-09 00:00:00

  • Registered report: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.

    abstract::The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, were selected on the...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.12470

    authors: Phelps M,Coss C,Wang H,Cook M,Reproducibility Project: Cancer Biology.,Reproducibility Project Cancer Biology.

    更新日期:2016-03-01 00:00:00

  • Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states.

    abstract::To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away from biotin after enrichment, and a spacer arm that can be label...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.12509

    authors: Tan D,Li Q,Zhang MJ,Liu C,Ma C,Zhang P,Ding YH,Fan SB,Tao L,Yang B,Li X,Ma S,Liu J,Feng B,Liu X,Wang HW,He SM,Gao N,Ye K,Dong MQ,Lei X

    更新日期:2016-03-08 00:00:00

  • Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.

    abstract::Mitogen-activated protein kinases (MAPK) such as p38 and the c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. Their activity is regulated by the MAPK-phosphatase 1 (DUSP1), a key component of the anti-inflammatory response. Stress kinases are well-described elements of the ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.39159

    authors: Celaya AM,Sánchez-Pérez I,Bermúdez-Muñoz JM,Rodríguez-de la Rosa L,Pintado-Berninches L,Perona R,Murillo-Cuesta S,Varela-Nieto I

    更新日期:2019-04-02 00:00:00

  • Effectiveness of traveller screening for emerging pathogens is shaped by epidemiology and natural history of infection.

    abstract::During outbreaks of high-consequence pathogens, airport screening programs have been deployed to curtail geographic spread of infection. The effectiveness of screening depends on several factors, including pathogen natural history and epidemiology, human behavior, and characteristics of the source epidemic. We develop...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.05564

    authors: Gostic KM,Kucharski AJ,Lloyd-Smith JO

    更新日期:2015-02-19 00:00:00

  • Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production.

    abstract::Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis. Ndst1+ OLG ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.51735

    authors: Macchi M,Magalon K,Zimmer C,Peeva E,El Waly B,Brousse B,Jaekel S,Grobe K,Kiefer F,Williams A,Cayre M,Durbec P

    更新日期:2020-06-09 00:00:00

  • MELK expression correlates with tumor mitotic activity but is not required for cancer growth.

    abstract::The Maternal Embryonic Leucine Zipper Kinase (MELK) has been identified as a promising therapeutic target in multiple cancer types. MELK over-expression is associated with aggressive disease, and MELK has been implicated in numerous cancer-related processes, including chemotherapy resistance, stem cell renewal, and tu...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.32838

    authors: Giuliano CJ,Lin A,Smith JC,Palladino AC,Sheltzer JM

    更新日期:2018-02-08 00:00:00

  • Estimating and interpreting nonlinear receptive field of sensory neural responses with deep neural network models.

    abstract::Our understanding of nonlinear stimulus transformations by neural circuits is hindered by the lack of comprehensive yet interpretable computational modeling frameworks. Here, we propose a data-driven approach based on deep neural networks to directly model arbitrarily nonlinear stimulus-response mappings. Reformulatin...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.53445

    authors: Keshishian M,Akbari H,Khalighinejad B,Herrero JL,Mehta AD,Mesgarani N

    更新日期:2020-06-26 00:00:00

  • Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast.

    abstract::Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Here we identify causes underlying hybrid infertility of two recently diverged fission yeast species Schizosaccharomyces pombe and S. kambucha, which mate to form viable hybrid diploids that effici...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.02630

    authors: Zanders SE,Eickbush MT,Yu JS,Kang JW,Fowler KR,Smith GR,Malik HS

    更新日期:2014-06-24 00:00:00

  • TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb.

    abstract::Comprehensively elucidating the molecular mechanisms of human immunodeficiency virus type 1 (HIV-1) latency is a priority to achieve a functional cure. As current 'shock' agents failed to efficiently reactivate the latent reservoir, it is important to discover new targets for developing more efficient latency-reversin...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.42426

    authors: Ma X,Yang T,Luo Y,Wu L,Jiang Y,Song Z,Pan T,Liu B,Liu G,Liu J,Yu F,He Z,Zhang W,Yang J,Liang L,Guan Y,Zhang X,Li L,Cai W,Tang X,Gao S,Deng K,Zhang H

    更新日期:2019-01-17 00:00:00

  • Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry.

    abstract::Pancreatic ATP-sensitive K+ channels (KATP) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts KATP. Mg-nucleotide binding to SUR1 stimulates KATP. In the absence of Mg2+, SUR1 increases the apparent affinity for nucleotide inhibition...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.52775

    authors: Usher SG,Ashcroft FM,Puljung MC

    更新日期:2020-01-07 00:00:00

  • The contribution of temporal coding to odor coding and odor perception in humans.

    abstract::Whether neurons encode information through their spike rates, their activity times or both is an ongoing debate in systems neuroscience. Here, we tested whether humans can discriminate between a pair of temporal odor mixtures (TOMs) composed of the same two components delivered in rapid succession in either one tempor...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.49734

    authors: Perl O,Nahum N,Belelovsky K,Haddad R

    更新日期:2020-02-07 00:00:00

  • Correction: Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein.

    abstract:: ...

    journal_title:eLife

    pub_type: 已发布勘误

    doi:10.7554/eLife.66683

    authors: Hayasaka N,Hirano A,Miyoshi Y,Tokuda IT,Yoshitane H,Matsuda J,Fukada Y

    更新日期:2021-01-25 00:00:00

  • Division of labor in bacteria.

    abstract::The emergence of subpopulations that perform distinct metabolic roles has been observed in populations of genetically identical bacteria. ...

    journal_title:eLife

    pub_type: 评论,杂志文章

    doi:10.7554/eLife.38578

    authors: Dal Co A,Brannon C,Ackermann M

    更新日期:2018-06-29 00:00:00

  • Extensive ribosome and RF2 rearrangements during translation termination.

    abstract::Protein synthesis ends when a ribosome reaches an mRNA stop codon. Release factors (RFs) decode the stop codon, hydrolyze peptidyl-tRNA to release the nascent protein, and then dissociate to allow ribosome recycling. To visualize termination by RF2, we resolved a cryo-EM ensemble of E. coli 70S•RF2 structures at up to...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.46850

    authors: Svidritskiy E,Demo G,Loveland AB,Xu C,Korostelev AA

    更新日期:2019-09-12 00:00:00

  • Absent phasing of respiratory and locomotor rhythms in running mice.

    abstract::Examining whether and how the rhythms of limb and breathing movements interact is highly informative about the mechanistic origin of hyperpnoea during running exercise. However, studies have failed to reveal regularities. In particular, whether breathing frequency is inherently proportional to limb velocity and impose...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.61919

    authors: Hérent C,Diem S,Fortin G,Bouvier J

    更新日期:2020-12-01 00:00:00

  • Intracellular sphingosine releases calcium from lysosomes.

    abstract::To elucidate new functions of sphingosine (Sph), we demonstrate that the spontaneous elevation of intracellular Sph levels via caged Sph leads to a significant and transient calcium release from acidic stores that is independent of sphingosine 1-phosphate, extracellular and ER calcium levels. This photo-induced Sph-dr...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.10616

    authors: Höglinger D,Haberkant P,Aguilera-Romero A,Riezman H,Porter FD,Platt FM,Galione A,Schultz C

    更新日期:2015-11-27 00:00:00

  • USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

    abstract::Physiological adaptation to proteotoxic stress in the endoplasmic reticulum (ER) requires retrotranslocation of misfolded proteins into the cytoplasm for ubiquitination and elimination by ER-associated degradation (ERAD). A surprising paradox emerging from recent studies is that ubiquitin ligases (E3s) and deubiquitin...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.01369

    authors: Liu Y,Soetandyo N,Lee JG,Liu L,Xu Y,Clemons WM Jr,Ye Y

    更新日期:2014-01-01 00:00:00

  • Kinesin and dynein use distinct mechanisms to bypass obstacles.

    abstract::Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm. Here, we tested the ability of single and multiple motors to bypass synthetic obstacles on MTs in vitro....

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.48629

    authors: Ferro LS,Can S,Turner MA,ElShenawy MM,Yildiz A

    更新日期:2019-09-09 00:00:00

  • CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization.

    abstract::The choroid, which provides vascular supply to the outer retina, demonstrates progressive degeneration in aging and age-related macular degeneration (AMD). However mechanisms that maintain or compromise choroidal homeostasis are obscure. We discovered that the ablation of choroidal macrophages via CSF1R blockade was a...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.55564

    authors: Yang X,Zhao L,Campos MM,Abu-Asab M,Ortolan D,Hotaling N,Bharti K,Wong WT

    更新日期:2020-04-01 00:00:00

  • Structural basis of TRPC4 regulation by calmodulin and pharmacological agents.

    abstract::Canonical transient receptor potential channels (TRPC) are involved in receptor-operated and/or store-operated Ca2+ signaling. Inhibition of TRPCs by small molecules was shown to be promising in treating renal diseases. In cells, the channels are regulated by calmodulin (CaM). Molecular details of both CaM and drug bi...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.60603

    authors: Vinayagam D,Quentin D,Yu-Strzelczyk J,Sitsel O,Merino F,Stabrin M,Hofnagel O,Yu M,Ledeboer MW,Nagel G,Malojcic G,Raunser S

    更新日期:2020-11-25 00:00:00

  • Taking aim at Sox18.

    abstract::A small molecule called Sm4 can disrupt interactions involving a transcription factor called Sox18, while having little impact on other members of the SoxF family. ...

    journal_title:eLife

    pub_type: 评论,杂志文章

    doi:10.7554/eLife.24238

    authors: Kim I,Koh GY

    更新日期:2017-01-31 00:00:00

  • A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe.

    abstract::Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia affecting geographically distant populations of two species of mussels (Mytilus chilensis in South America and M. edulis in Eur...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.47788

    authors: Yonemitsu MA,Giersch RM,Polo-Prieto M,Hammel M,Simon A,Cremonte F,Avilés FT,Merino-Véliz N,Burioli EA,Muttray AF,Sherry J,Reinisch C,Baldwin SA,Goff SP,Houssin M,Arriagada G,Vázquez N,Bierne N,Metzger MJ

    更新日期:2019-11-05 00:00:00

  • Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.

    abstract::The application of current channelrhodopsin-based optogenetic tools is limited by the lack of strict ion selectivity and the inability to extend the spectra sensitivity into the near-infrared (NIR) tissue transmissible range. Here we present an NIR-stimulable optogenetic platform (termed 'Opto-CRAC') that selectively ...

    journal_title:eLife

    pub_type: 杂志文章

    doi:10.7554/eLife.10024

    authors: He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y

    更新日期:2015-12-08 00:00:00