Abstract:
:Experience-dependent modifications of synaptic connections are thought to change patterns of network activities and stimulus tuning with learning. However, only a few studies explored how synaptic plasticity shapes the response dynamics of cortical circuits. Here, we investigated the mechanism underlying sharpening of both stimulus selectivity and response dynamics with familiarity observed in monkey inferotemporal cortex. Broadening the distribution of activities and stronger oscillations in the response dynamics after learning provide evidence for synaptic plasticity in recurrent connections modifying the strength of positive feedback. Its interplay with slow negative feedback via firing rate adaptation is critical in sharpening response dynamics. Analysis of changes in temporal patterns also enables us to disentangle recurrent and feedforward synaptic plasticity and provides a measure for the strengths of recurrent synaptic plasticity. Overall, this work highlights the importance of analyzing changes in dynamics as well as network patterns to further reveal the mechanisms of visual learning.
journal_name
Elifejournal_title
eLifeauthors
Lim Sdoi
10.7554/eLife.44098subject
Has Abstractpub_date
2019-08-08 00:00:00issn
2050-084Xpii
44098journal_volume
8pub_type
杂志文章相关文献
eLife文献大全abstract::Deinococcus radiodurans (DR) survives in the presence of hundreds of double-stranded DNA (dsDNA) breaks by efficiently repairing such breaks. RecO, a protein that is essential for the extreme radioresistance of DR, is one of the major recombination mediator proteins in the RecA-loading process in the RecFOR pathway. H...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50945
更新日期:2020-04-16 00:00:00
abstract::Hawaiian isolates of the nematode species Caenorhabditis elegans have long been known to harbor genetic diversity greater than the rest of the worldwide population, but this observation was supported by only a small number of wild strains. To better characterize the niche and genetic diversity of Hawaiian C. elegans a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50465
更新日期:2019-12-03 00:00:00
abstract::TMEM16A is a ligand-gated anion channel that is activated by intracellular Ca2+. This channel comprises two independent pores and closely apposed Ca2+ binding sites that are contained within each subunit of a homodimeric protein. Previously we characterized the influence of positively charged pore-lining residues on a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39122
更新日期:2018-10-12 00:00:00
abstract::Dorsal/ventral (DV) patterning of the sea urchin embryo relies on a ventrally-localized organizer expressing Nodal, a pivotal regulator of the DV gene regulatory network. However, the inceptive mechanisms imposing the symmetry-breaking are incompletely understood. In Paracentrotus lividus, the Hbox12 homeodomain-conta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04664
更新日期:2014-12-02 00:00:00
abstract::Transposable elements (TEs), the movement of which can damage the genome, are epigenetically silenced in eukaryotes. Intriguingly, TEs are activated in the sperm companion cell - vegetative cell (VC) - of the flowering plant Arabidopsis thaliana. However, the extent and mechanism of this activation are unknown. Here w...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.42530
更新日期:2019-05-28 00:00:00
abstract::In complex biological systems, simple individual-level behavioral rules can give rise to emergent group-level behavior. While collective behavior has been well studied in cells and larger organisms, the mesoscopic scale is less understood, as it is unclear which sensory inputs and physical processes matter a priori. H...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.43318
更新日期:2019-04-25 00:00:00
abstract::Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry. We discovered distinct age-related changes in both model organisms. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.24662
更新日期:2017-07-12 00:00:00
abstract::A pair of neurons is required for nematodes to be able to navigate using the Earth's magnetic field. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.09666
更新日期:2015-08-05 00:00:00
abstract::The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome-wide association studies on 78 facial shape phenotypes quantified from 3-dimensional facial images of 10,115 Europeans identif...
journal_title:eLife
pub_type: 杂志文章,meta分析
doi:10.7554/eLife.49898
更新日期:2019-11-26 00:00:00
abstract::The calcium release-activated calcium channel Orai regulates Ca2+ entry into non-excitable cells and is required for proper immune function. While the channel typically opens following Ca2+ release from the endoplasmic reticulum, certain pathologic mutations render the channel constitutively open. Previously, using on...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.62772
更新日期:2020-11-30 00:00:00
abstract::A small molecule called Sm4 can disrupt interactions involving a transcription factor called Sox18, while having little impact on other members of the SoxF family. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.24238
更新日期:2017-01-31 00:00:00
abstract::Translation is a core cellular process carried out by a highly conserved macromolecular machine, the ribosome. There has been remarkable evolutionary adaptation of this machine through the addition of eukaryote-specific ribosomal proteins whose individual effects on ribosome function are largely unknown. Here we show ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11154
更新日期:2016-04-27 00:00:00
abstract::The Maternal Embryonic Leucine Zipper Kinase (MELK) has been identified as a promising therapeutic target in multiple cancer types. MELK over-expression is associated with aggressive disease, and MELK has been implicated in numerous cancer-related processes, including chemotherapy resistance, stem cell renewal, and tu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.32838
更新日期:2018-02-08 00:00:00
abstract::A heat exchange mechanism in the head of kissing bugs helps to prevent stress and regulate their temperature while they feed on warm blood. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.33035
更新日期:2017-11-21 00:00:00
abstract::Dopamine neurons respond to errors in predicting value-neutral sensory information. These data, combined with causal evidence that dopamine transients support sensory-based associative learning, suggest that the dopamine system signals a multidimensional prediction error. Yet such complexity is not evident in the acti...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49315
更新日期:2019-11-01 00:00:00
abstract::Most evolutionary thinking is based on the notion of fitness and related ideas such as fitness landscapes and evolutionary optima. Nevertheless, it is often unclear what fitness actually is, and its meaning often depends on the context. Here we argue that fitness should not be a basal ingredient in verbal or mathemati...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23804
更新日期:2017-02-15 00:00:00
abstract::Compartmentalized oscillations of second messengers affect global cellular signaling. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.63845
更新日期:2020-11-17 00:00:00
abstract::Innate lymphoid cells (ILCs) contribute to host defence and tissue repair but can induce immunopathology. Recent work has revealed tissue-specific roles for ILCs; however, the question of how a small population has large effects on immune homeostasis remains unclear. We identify two mechanisms that ILC3s utilise to ex...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10066
更新日期:2016-01-18 00:00:00
abstract::Bacterial flagella mediate host-microbe interactions through tissue tropism during colonization, as well as by activating immune responses. The flagellar shaft of some bacteria, including several human pathogens, is encased in a membranous sheath of unknown function. While it has been hypothesized that the sheath may ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01579
更新日期:2014-03-04 00:00:00
abstract::During inflammation, serum amyloid A proteins transport retinol to infected tissues. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.04246
更新日期:2014-09-02 00:00:00
abstract::Class IV ddaC neurons specifically prune larval dendrites without affecting axons during Drosophila metamorphosis. ddaCs distribute the minus ends of microtubules (MTs) to dendrites but the plus ends to axons. However, a requirement of MT minus-end-binding proteins in dendrite-specific pruning remains completely unkno...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39964
更新日期:2019-03-28 00:00:00
abstract::Negative feedback regulation, that is the ability of a gene to repress its own synthesis, is the most abundant regulatory motif known to biology. Frequently reported for transcriptional regulators, negative feedback control relies on binding of a transcription factor to its own promoter. Here, we report a novel mechan...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58836
更新日期:2020-08-03 00:00:00
abstract::Kinesin super family protein 2A (KIF2A), an ATP-dependent microtubule (MT) destabilizer, regulates cell migration, axon elongation, and pruning in the developing nervous system. KIF2A mutations have recently been identified in patients with malformed cortical development. However, postnatal KIF2A is continuously expre...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30935
更新日期:2018-01-09 00:00:00
abstract::Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. To test whether exosomal RNAs also contribute to changes in gene expression in recipient cells, and whether mutant KRAS might regulate the composition of secreted microRNAs (miRNAs), we compared small RN...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.07197
更新日期:2015-07-01 00:00:00
abstract::After paralyzing spinal cord injury the adult nervous system has little ability to 'heal' spinal connections, and it is assumed to be unable to develop extra-spinal recovery strategies to bypass the lesion. We challenge this assumption, showing that completely spinalized adult rats can recover unassisted hindlimb weig...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23532
更新日期:2017-06-29 00:00:00
abstract::Bacillus subtilis can measure the activity of the enzymes that remodel the cell wall to ensure that the levels of activity are 'just right'. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54244
更新日期:2020-01-24 00:00:00
abstract::How mammalian tissues maintain their architecture and tissue-specificity is poorly understood. Previously, we documented both the indispensable role of the extracellular matrix (ECM) protein, laminin-111 (LN1), in the formation of normal breast acini, and the phenotypic reversion of cancer cells to acini-like structur...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26148
更新日期:2018-03-21 00:00:00
abstract::The Hippo-YAP pathway is a central regulator of cell contact inhibition, proliferation and death. There are conflicting reports regarding the role of Angiomotin (Amot) in regulating this pathway. While some studies suggest a YAP-inhibitory function other studies indicate Amot is required for YAP activity. Here, we des...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.23966
更新日期:2017-05-03 00:00:00
abstract::Kinesin-1 and cytoplasmic dynein are microtubule (MT) motors that transport intracellular cargoes. It remains unclear how these motors move along MTs densely coated with obstacles of various sizes in the cytoplasm. Here, we tested the ability of single and multiple motors to bypass synthetic obstacles on MTs in vitro....
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.48629
更新日期:2019-09-09 00:00:00
abstract::The expression of E-Cadherin, a protein best known for its role in cell adhesion, regulates the onset of embryonic differentiation. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.01839
更新日期:2013-12-17 00:00:00