Abstract:
:The Maternal Embryonic Leucine Zipper Kinase (MELK) has been identified as a promising therapeutic target in multiple cancer types. MELK over-expression is associated with aggressive disease, and MELK has been implicated in numerous cancer-related processes, including chemotherapy resistance, stem cell renewal, and tumor growth. Previously, we established that triple-negative breast cancer cell lines harboring CRISPR/Cas9-induced null mutations in MELK proliferate at wild-type levels in vitro (
journal_name
Elifejournal_title
eLifeauthors
Giuliano CJ,Lin A,Smith JC,Palladino AC,Sheltzer JMdoi
10.7554/eLife.32838subject
Has Abstractpub_date
2018-02-08 00:00:00issn
2050-084Xpii
32838journal_volume
7pub_type
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