Abstract:
:With implantation, mouse stromal cells begin to transform into epithelial-like cells surrounding the implantation chamber forming an avascular zone called the primary decidual zone (PDZ). In the mouse, the PDZ forms a transient, size-dependent permeable barrier to protect the embryo from maternal circulating harmful agents. The process of decidualization is critical for pregnancy maintenance in mice and humans. Mice deficient in cannabinoid receptors, CB1 and CB2, show compromised PDZ with dysregulated angiogenic factors, resulting in the retention of blood vessels and macrophages. This phenotype is replicated in Cnr1-/- but not in Cnr2-/-mice. In vitro decidualization models suggest that Cnr1 levels substantially increase in mouse and human decidualizing stromal cells, and that neutralization of CB1 signaling suppresses decidualization and misregulates angiogenic factors. Taken together, we propose that implantation quality depends on appropriate angiogenic events driven by the integration of CB2 in endothelial cells and CB1 in decidual cells.
journal_name
Elifejournal_title
eLifeauthors
Li Y,Dewar A,Kim YS,Dey SK,Sun Xdoi
10.7554/eLife.61762subject
Has Abstractpub_date
2020-09-29 00:00:00issn
2050-084Xpii
61762journal_volume
9pub_type
杂志文章相关文献
eLife文献大全abstract::Macrophage activation/polarization to distinct functional states is critically supported by metabolic shifts. How polarizing signals coordinate metabolic and functional reprogramming, and the potential implications for control of macrophage activation, remains poorly understood. Here we show that IL-4 signaling co-opt...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11612
更新日期:2016-02-19 00:00:00
abstract::Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides. We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Ascaris worm. An additional 68 worms were collected from 60 human hosts in Kenyan vil...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.61562
更新日期:2020-11-06 00:00:00
abstract::Plasma cells (PCs) are essential for protection from infection, and at the origin of incurable cancers. Current studies do not circumvent the limitations of removing PCs from their microenvironment and confound formation and maintenance. Also, the investigation of PC population dynamics has mostly relied on nucleotide...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59850
更新日期:2020-11-02 00:00:00
abstract::The neural correlates of consciousness are typically sought by comparing the overall brain responses to perceived and unperceived stimuli. However, this comparison may be contaminated by non-specific attention, alerting, performance, and reporting confounds. Here, we pursue a novel approach, tracking the neuronal codi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.05652
更新日期:2015-05-21 00:00:00
abstract::Over 80% of multiple-tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death characterized by simultaneous activation of multiple cell death pathways preferentially killing transformed and cancer stem cells. We now show these si/shRNAs kill cancer cells through canonical RNAi by targ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.29702
更新日期:2017-10-24 00:00:00
abstract::Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. Here, we demonstrate that chromatin-associated RNA contributes to the stable association of SUV39H...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25299
更新日期:2017-08-01 00:00:00
abstract::Experience-dependent modifications of synaptic connections are thought to change patterns of network activities and stimulus tuning with learning. However, only a few studies explored how synaptic plasticity shapes the response dynamics of cortical circuits. Here, we investigated the mechanism underlying sharpening of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44098
更新日期:2019-08-08 00:00:00
abstract::Secondary metabolites have a great potential as pharmaceuticals, but there are only a few examples where regulation of gene cluster expression has been correlated with ecological and physiological relevance for the producer. Here, signals, mediators, and biological effects of terrein production were studied in the fun...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.07861
更新日期:2015-07-14 00:00:00
abstract::The ubiquitous presence of inhibitory interneurons in the thalamus of primates contrasts with the sparsity of interneurons reported in mice. Here, we identify a larger than expected complexity and distribution of interneurons across the mouse thalamus, where all thalamic interneurons can be traced back to two developm...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59272
更新日期:2021-02-01 00:00:00
abstract::The genome-scale transcriptional programs that specify the mammalian trachea and esophagus are unknown. Though NKX2-1 and SOX2 are hypothesized to be co-repressive master regulators of tracheoesophageal fates, this is untested at a whole transcriptomic scale and their downstream networks remain unidentified. By combin...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55526
更新日期:2020-06-09 00:00:00
abstract::Notch signaling plays a crucial role in controling the proliferation and differentiation of stem and progenitor cells during embryogenesis or organogenesis, but its regulation is incompletely understood. BLOS2, encoded by the Bloc1s2 gene, is a shared subunit of two lysosomal trafficking complexes, biogenesis of lysos...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18108
更新日期:2016-10-10 00:00:00
abstract::Little is known about venom in young developmental stages of animals. The appearance of toxins and stinging cells during early embryonic stages in the sea anemone Nematostella vectensis suggests that venom is already expressed in eggs and larvae of this species. Here, we harness transcriptomic, biochemical and transge...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35014
更新日期:2018-02-09 00:00:00
abstract::How does attentional modulation of neural activity enhance performance? Here we use a deep convolutional neural network as a large-scale model of the visual system to address this question. We model the feature similarity gain model of attention, in which attentional modulation is applied according to neural stimulus ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.38105
更新日期:2018-10-01 00:00:00
abstract::Direct reprogramming of fibroblasts to neurons induces widespread cellular and transcriptional reconfiguration. Here, we characterized global epigenomic changes during the direct reprogramming of mouse fibroblasts to neurons using whole-genome base-resolution DNA methylation (mC) sequencing. We found that the pioneer ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40197
更新日期:2019-01-15 00:00:00
abstract::In eukaryotes, intra-chromosomal recombination generates DNA circles, but little is known about how cells react to them. In yeast, partitioning of such circles to the mother cell at mitosis ensures their loss from the population but promotes replicative ageing. Nevertheless, the mechanisms of partitioning are debated....
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03790
更新日期:2014-11-17 00:00:00
abstract::Humans employ different strategies when making decisions. Previous research has reported reduced reliance on model-based strategies with aging, but it remains unclear whether this is due to cognitive or motivational factors. Moreover, it is not clear how aging affects the metacontrol of decision making, that is the dy...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49154
更新日期:2019-08-09 00:00:00
abstract::The pressure for every research article to tell a clear story often leads researchers in the life sciences to exclude experiments that 'did not work' when they write up their results. However, this practice can lead to reporting bias if the decisions about which experiments to exclude are taken after data have been co...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56626
更新日期:2020-05-22 00:00:00
abstract::Glutaminase (GLS) isoenzymes GLS1 and GLS2 are key enzymes for glutamine metabolism. Interestingly, GLS1 and GLS2 display contrasting functions in tumorigenesis with elusive mechanism; GLS1 promotes tumorigenesis, whereas GLS2 exhibits a tumor-suppressive function. In this study, we found that GLS2 but not GLS1 binds ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10727
更新日期:2016-01-11 00:00:00
abstract::MyD88 is the main adaptor molecule for TLR and IL-1R family members. Here, we demonstrated that T-cell intrinsic MyD88 signaling is required for proliferation, protection from apoptosis and expression of activation/memory genes during infection with the intracellular parasite Trypanosoma cruzi, as evidenced by transcr...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30883
更新日期:2017-09-12 00:00:00
abstract::Perturbation of neuronal activity is key to understanding the brain's functional properties, however, intervention studies typically perturb neurons in a nonspecific manner. Recent optogenetics techniques have enabled patterned perturbations, in which specific patterns of activity can be invoked in identified target n...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52757
更新日期:2020-02-19 00:00:00
abstract::Pancreatic ATP-sensitive K+ channels (KATP) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts KATP. Mg-nucleotide binding to SUR1 stimulates KATP. In the absence of Mg2+, SUR1 increases the apparent affinity for nucleotide inhibition...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52775
更新日期:2020-01-07 00:00:00
abstract::Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR) pathways. Like mice lacking primary UPR components, hepatic Lrh-1-null m...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01694
更新日期:2014-04-15 00:00:00
abstract::Understanding how genetic variation contributes to phenotypic differences is a fundamental question in biology. Combining high-throughput gene function assays with mechanistic models of the impact of genetic variants is a promising alternative to genome-wide association studies. Here we have assembled a large panel of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.31035
更新日期:2017-12-27 00:00:00
abstract::In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Kandela et al., 2015) that described how we intended to replicate selected experiments from the paper "BET bromodomain inhibition as a therapeutic strategy to target c-Myc" (Delmore et al., 2011). Here we report the resu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21253
更新日期:2017-01-19 00:00:00
abstract::Using knowledge of the structure of the world to infer value is at the heart of model-based reasoning and relies on a circuit that includes the orbitofrontal cortex (OFC). Some accounts link this to the representation of biological significance or value by neurons in OFC, while other models focus on the representation...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30373
更新日期:2018-03-07 00:00:00
abstract::Cell fate decisions are critical for life, yet little is known about how their reliability is achieved when signals are noisy and fluctuating with time. In this study, we show that in budding yeast, the decision of cell cycle commitment (Start) is determined by the time integration of its triggering signal Cln3. We fu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03977
更新日期:2015-01-14 00:00:00
abstract::A new source of progenitor cells can now be used to study hidden aspects of human lung development and pediatric lung disease. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.30194
更新日期:2017-08-14 00:00:00
abstract::Clustering of receptors associated with immunoreceptor tyrosine-based activation motifs (ITAMs) initiates the macrophage antimicrobial response. ITAM receptors engage Src-family tyrosine kinases (SFKs) to initiate phagocytosis and macrophage activation. Macrophages also encounter nonpathogenic molecules that cluster r...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09183
更新日期:2015-10-30 00:00:00
abstract::While specific mutations allow organisms to adapt to stressful environments, most changes in an organism's DNA negatively impact fitness. The mutation rate is therefore strictly regulated and often considered a slowly-evolving parameter. In contrast, we demonstrate an unexpected flexibility in cellular mutation rates ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22939
更新日期:2017-05-02 00:00:00
abstract::The COVID-19 pandemic has resulted in school closures and distancing requirements that have disrupted both work and family life for many. Concerns exist that these disruptions caused by the pandemic may not have influenced men and women researchers equally. Many medical journals have published papers on the pandemic, ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58807
更新日期:2020-06-15 00:00:00