COVID-19 medical papers have fewer women first authors than expected.

abstract：:The Hippo-YAP pathway is a central regulator of cell contact inhibition, proliferation and death. There are conflicting reports regarding the role of Angiomotin (Amot) in regulating this pathway. While some studies suggest a YAP-inhibitory function other studies indicate Amot is required for YAP activity. Here, we des...

journal_title：eLife

authors： Moleirinho S,Hoxha S,Mandati V,Curtale G,Troutman S,Ehmer U,Kissil JL

更新日期：2017-05-03 00:00:00

abstract：:There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction. In this study, using single-session extinction trai...

journal_title：eLife

authors： An B,Kim J,Park K,Lee S,Song S,Choi S

更新日期：2017-07-03 00:00:00

abstract：:The NuRD complex subunit CHD4 is essential for fusion-positive rhabdomyosarcoma (FP-RMS) survival, but the mechanisms underlying this dependency are not understood. Here, a NuRD-specific CRISPR screen demonstrates that FP-RMS is particularly sensitive to CHD4 amongst the NuRD members. Mechanistically, NuRD complex con...

journal_title：eLife

authors： Marques JG,Gryder BE,Pavlovic B,Chung Y,Ngo QA,Frommelt F,Gstaiger M,Song Y,Benischke K,Laubscher D,Wachtel M,Khan J,Schäfer BW

更新日期：2020-08-03 00:00:00

abstract：:Congenital diaphragmatic hernia (CDH) is a severe birth defect. Wt1-null mouse embryos develop CDH but the mechanisms regulated by WT1 are unknown. We have generated a murine model with conditional deletion of WT1 in the lateral plate mesoderm, using the G2 enhancer of the Gata4 gene as a driver. 80% of G2-Gata4(Cre);...

journal_title：eLife

authors： Carmona R,Cañete A,Cano E,Ariza L,Rojas A,Muñoz-Chápuli R

更新日期：2016-09-19 00:00:00

abstract：:The nematode Caenorhabditis elegans possesses a simple embryonic nervous system with few enough neurons that the growth of each cell could be followed to provide a systems-level view of development. However, studies of single cell development have largely been conducted in fixed or pre-twitching live embryos, because ...

journal_title：eLife

authors： Christensen RP,Bokinsky A,Santella A,Wu Y,Marquina-Solis J,Guo M,Kovacevic I,Kumar A,Winter PW,Tashakkori N,McCreedy E,Liu H,McAuliffe M,Mohler W,Colón-Ramos DA,Bao Z,Shroff H

更新日期：2015-12-03 00:00:00

abstract：:Atopic Dermatitis (AD) is a T cell-mediated chronic skin disease and is associated with altered skin barrier integrity. Infants with mutations in genes involved in tissue barrier fitness are predisposed towards inflammatory diseases, but most do not develop or sustain the diseases, suggesting that there exist regulato...

journal_title：eLife

authors： Spidale NA,Malhotra N,Frascoli M,Sylvia K,Miu B,Freeman C,Stadinski BD,Huseby E,Kang J

更新日期：2020-02-17 00:00:00

abstract：:The COVID-19 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a story about the numbers. In this article we provide a one-stop, curated graphical source for the key numbers (based mostly on the peer-reviewed literature) abou...

journal_title：eLife

authors： Bar-On YM,Flamholz A,Phillips R,Milo R

更新日期：2020-04-02 00:00:00

abstract：:Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability. Computer simulations predicted that qualitative changes in primary afferent excitability linked to neuropathic pain arise through a switch in spike initiation dynamics when...

journal_title：eLife

authors： Ratté S,Zhu Y,Lee KY,Prescott SA

更新日期：2014-04-01 00:00:00

abstract：:Genomic sequencing has implicated large numbers of genes and de novo mutations as potential disease risk factors. A high throughput in vivo model system is needed to validate gene associations with pathology. We developed a Drosophila-based functional system to screen candidate disease genes identified from Congenital...

journal_title：eLife

authors： Zhu JY,Fu Y,Nettleton M,Richman A,Han Z

更新日期：2017-01-20 00:00:00

abstract：:Neural circuits that control copulation in male flies have been identified. ...

journal_title：eLife

authors： Levine J

更新日期：2016-11-15 00:00:00

abstract：:Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is proposed to be the sole e...

journal_title：eLife

authors： Pettinati I,Grzechnik P,Ribeiro de Almeida C,Brem J,McDonough MA,Dhir S,Proudfoot NJ,Schofield CJ

更新日期：2018-12-03 00:00:00

abstract：:We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism was unknown. Here we show E. faecium has unique peptidoglycan comp...

journal_title：eLife

authors： Kim B,Wang YC,Hespen CW,Espinosa J,Salje J,Rangan KJ,Oren DA,Kang JY,Pedicord VA,Hang HC

更新日期：2019-04-10 00:00:00

abstract：:Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In Drosophila, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional understanding of the LH is scant, in large part due to a lack of sparse neurogenetic t...

journal_title：eLife

authors： Dolan MJ,Frechter S,Bates AS,Dan C,Huoviala P,Roberts RJ,Schlegel P,Dhawan S,Tabano R,Dionne H,Christoforou C,Close K,Sutcliffe B,Giuliani B,Li F,Costa M,Ihrke G,Meissner GW,Bock DD,Aso Y,Rubin GM,Jefferis GS

更新日期：2019-05-21 00:00:00

abstract：:Signaling by the G-protein-coupled receptors (GPCRs) plays fundamental role in a vast number of essential physiological functions. Precise control of GPCR signaling requires action of regulators of G protein signaling (RGS) proteins that deactivate heterotrimeric G proteins. RGS proteins are elaborately regulated and ...

journal_title：eLife

authors： Patil DN,Rangarajan ES,Novick SJ,Pascal BD,Kojetin DJ,Griffin PR,Izard T,Martemyanov KA

更新日期：2018-12-12 00:00:00

abstract：:Responses of sensory neurons are often modeled using a weighted combination of rectified linear subunits. Since these subunits often cannot be measured directly, a flexible method is needed to infer their properties from the responses of downstream neurons. We present a method for maximum likelihood estimation of subu...

journal_title：eLife

authors： Shah NP,Brackbill N,Rhoades C,Kling A,Goetz G,Litke AM,Sher A,Simoncelli EP,Chichilnisky EJ

更新日期：2020-03-09 00:00:00

abstract：:Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently completed dense connectome,...

journal_title：eLife

authors： Li F,Lindsey JW,Marin EC,Otto N,Dreher M,Dempsey G,Stark I,Bates AS,Pleijzier MW,Schlegel P,Nern A,Takemura SY,Eckstein N,Yang T,Francis A,Braun A,Parekh R,Costa M,Scheffer LK,Aso Y,Jefferis GS,Abbott LF,Litwi

更新日期：2020-12-14 00:00:00

abstract：:Human-based modelling and simulations are becoming ubiquitous in biomedical science due to their ability to augment experimental and clinical investigations. Cardiac electrophysiology is one of the most advanced areas, with cardiac modelling and simulation being considered for virtual testing of pharmacological therap...

journal_title：eLife

authors： Tomek J,Bueno-Orovio A,Passini E,Zhou X,Minchole A,Britton O,Bartolucci C,Severi S,Shrier A,Virag L,Varro A,Rodriguez B

更新日期：2019-12-24 00:00:00

abstract：:The neural control of transition between posture and movement encompasses the regulation of reflex-stabilizing mechanisms to enable motion. Optimal feedback theory suggests that such transitions require the disengagement of one motor control policy before the implementation of another. To test this possibility, we inv...

journal_title：eLife

authors： Tisserand R,Dakin CJ,Van der Loos MH,Croft EA,Inglis TJ,Blouin JS

更新日期：2018-07-10 00:00:00

abstract：:Although individuals of many species inexorably age, a number of observations established that the rate of aging is modulated in response to a variety of mild stresses. Here, we investigated how heat stress promotes longevity in yeast. We show that upon growth at higher temperature, yeast cells relax the retention of ...

journal_title：eLife

authors： Baldi S,Bolognesi A,Meinema AC,Barral Y

更新日期：2017-12-28 00:00:00

abstract：:Activation of systemic acquired resistance in plants is associated with transcriptome reprogramming induced by the unstable coactivator NPR1. Immune-induced ubiquitination and proteasomal degradation of NPR1 are thought to facilitate continuous delivery of active NPR1 to target promoters, thereby maximising gene expre...

journal_title：eLife

authors： Skelly MJ,Furniss JJ,Grey H,Wong KW,Spoel SH

更新日期：2019-10-07 00:00:00

abstract：:The straight-tusked elephants Palaeoloxodon spp. were widespread across Eurasia during the Pleistocene. Phylogenetic reconstructions using morphological traits have grouped them with Asian elephants (Elephas maximus), and many paleontologists place Palaeoloxodon within Elephas. Here, we report the recovery of full mit...

journal_title：eLife

authors： Meyer M,Palkopoulou E,Baleka S,Stiller M,Penkman KEH,Alt KW,Ishida Y,Mania D,Mallick S,Meijer T,Meller H,Nagel S,Nickel B,Ostritz S,Rohland N,Schauer K,Schüler T,Roca AL,Reich D,Shapiro B,Hofreiter M

更新日期：2017-06-06 00:00:00

abstract：:The ellipsoid body (EB) in the Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination functions. However, what regulates R axon lamination and how lamination affects R neuron function re...

journal_title：eLife

authors： Xie X,Tabuchi M,Brown MP,Mitchell SP,Wu MN,Kolodkin AL

更新日期：2017-06-20 00:00:00

abstract：:The immediate evolutionary space accessible to HIV is largely determined by how single amino acid mutations affect fitness. These mutational effects can shift as the virus evolves. However, the prevalence of such shifts in mutational effects remains unclear. Here, we quantify the effects on viral growth of all amino a...

journal_title：eLife

authors： Haddox HK,Dingens AS,Hilton SK,Overbaugh J,Bloom JD

更新日期：2018-03-28 00:00:00

abstract：:Cerebellar climbing fiber activity encodes performance errors during many motor learning tasks, but the role of these error signals in learning has been controversial. We compared two motor learning paradigms that elicited equally robust putative error signals in the same climbing fibers: learned increases and decreas...

journal_title：eLife

authors： Kimpo RR,Rinaldi JM,Kim CK,Payne HL,Raymond JL

更新日期：2014-04-22 00:00:00

abstract：:The canonical action of the p85α regulatory subunit of phosphatidylinositol 3-kinase (PI3K) is to associate with the p110α catalytic subunit to allow stimuli-dependent activation of the PI3K pathway. We elucidate a p110α-independent role of homodimerized p85α in the positive regulation of PTEN stability and activity. ...

journal_title：eLife

authors： Cheung LW,Walkiewicz KW,Besong TM,Guo H,Hawke DH,Arold ST,Mills GB

更新日期：2015-07-29 00:00:00

abstract：:Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of precursor cells from mouse forebrain at embryonic days E8.5 vs. E10.5 (before vs. after neural tube closure). Genes encoding protein ...

journal_title：eLife

authors： Chau KF,Shannon ML,Fame RM,Fonseca E,Mullan H,Johnson MB,Sendamarai AK,Springel MW,Laurent B,Lehtinen MK

更新日期：2018-05-10 00:00:00

abstract：:Translesion DNA synthesis (TLS) during S-phase uses specialized TLS DNA polymerases to replicate a DNA lesion, allowing stringent DNA synthesis to resume beyond the offending damage. Human TLS involves the conjugation of ubiquitin to PCNA clamps encircling damaged DNA and the role of this post-translational modificati...

journal_title：eLife

authors： Hedglin M,Pandey B,Benkovic SJ

更新日期：2016-10-22 00:00:00

abstract：:We aimed to study time trends and levels of mean total cholesterol and lipid fractions, and dyslipidaemias prevalence in Latin America and the Caribbean (LAC). Systematic-review and meta-analysis of population-based studies in which lipid (total cholesterol [TC; 86 studies; 168,553 people], HDL-Cholesterol [HDL-C; 84 ...

journal_title：eLife

authors： Carrillo-Larco RM,Benites-Moya CJ,Anza-Ramirez C,Albitres-Flores L,Sánchez-Velazco D,Pacheco-Barrios N,Bernabe-Ortiz A

更新日期：2020-08-18 00:00:00

abstract：:An 'interactome' screen of all Drosophila cell-surface and secreted proteins containing immunoglobulin superfamily (IgSF) domains discovered a network formed by paralogs of Beaten Path (Beat) and Sidestep (Side), a ligand-receptor pair that is central to motor axon guidance. Here we describe a new method for interacto...

journal_title：eLife

authors： Li H,Watson A,Olechwier A,Anaya M,Sorooshyari SK,Harnett DP,Lee HP,Vielmetter J,Fares MA,Garcia KC,Özkan E,Labrador JP,Zinn K

更新日期：2017-08-15 00:00:00

abstract：:To elucidate new functions of sphingosine (Sph), we demonstrate that the spontaneous elevation of intracellular Sph levels via caged Sph leads to a significant and transient calcium release from acidic stores that is independent of sphingosine 1-phosphate, extracellular and ER calcium levels. This photo-induced Sph-dr...

journal_title：eLife

authors： Höglinger D,Haberkant P,Aguilera-Romero A,Riezman H,Porter FD,Platt FM,Galione A,Schultz C

更新日期：2015-11-27 00:00:00