Supplying the sleeping brain.

abstract：:T follicular helper cells (Tfh) are critical for the longevity and quality of antibody-mediated protection against infection. Yet few signaling pathways have been identified to be unique solely to Tfh development. ROQUIN is a post-transcriptional repressor of T cells, acting through its ROQ domain to destabilize mRNA ...

journal_title：eLife

authors： Ramiscal RR,Parish IA,Lee-Young RS,Babon JJ,Blagih J,Pratama A,Martin J,Hawley N,Cappello JY,Nieto PF,Ellyard JI,Kershaw NJ,Sweet RA,Goodnow CC,Jones RG,Febbraio MA,Vinuesa CG,Athanasopoulos V

更新日期：2015-10-23 00:00:00

abstract：:Contrary to dogma, evolutionarily young and dynamic genes can encode essential functions. We find that evolutionarily dynamic ZAD-ZNF genes, which encode the most abundant class of insect transcription factors, are more likely to encode essential functions in Drosophila melanogaster than ancient, conserved ZAD-ZNF gen...

journal_title：eLife

authors： Kasinathan B,Colmenares SU 3rd,McConnell H,Young JM,Karpen GH,Malik HS

更新日期：2020-11-10 00:00:00

abstract：:The IFNλ family of interferons controls the spread of viruses in the upper respiratory tract and transmission between mice. ...

journal_title：eLife

authors： Wack A

更新日期：2018-05-24 00:00:00

abstract：:The rhythm generating network for breathing must continuously adjust to changing metabolic and behavioral demands. Here, we examined network-based mechanisms in the mouse preBötzinger complex using substance P, a potent excitatory modulator of breathing frequency and stability, as a tool to dissect network properties ...

journal_title：eLife

authors： Baertsch NA,Ramirez JM

更新日期：2019-12-05 00:00:00

abstract：:Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear. Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed autophagic flux assays in multiple tissues of wild-type Caenorhabditis elegans and long-lived daf-2/insulin/...

journal_title：eLife

authors： Chang JT,Kumsta C,Hellman AB,Adams LM,Hansen M

更新日期：2017-07-04 00:00:00

abstract：:Yeast cells undergoing the diauxic response show a striking upstream shift in poly(A) site utilization, with increased use of ORF-proximal poly(A) sites resulting in shorter 3' mRNA isoforms for most genes. This altered poly(A) pattern is extremely similar to that observed in cells containing Pol II derivatives with s...

journal_title：eLife

authors： Geisberg JV,Moqtaderi Z,Struhl K

更新日期：2020-08-26 00:00:00

abstract：:Synaptic adhesion molecules regulate synapse development and function. However, whether and how presynaptic adhesion molecules regulate postsynaptic NMDAR function remains largely unclear. Presynaptic LAR family receptor tyrosine phosphatases (LAR-RPTPs) regulate synapse development through mechanisms that include tra...

journal_title：eLife

authors： Kim K,Shin W,Kang M,Lee S,Kim D,Kang R,Jung Y,Cho Y,Yang E,Kim H,Bae YC,Kim E

更新日期：2020-03-06 00:00:00

abstract：:Actin filaments assemble inside the nucleus in response to multiple cellular perturbations, including heat shock, protein misfolding, integrin engagement, and serum stimulation. We find that DNA damage also generates nuclear actin filaments-detectable by phalloidin and live-cell actin probes-with three characteristic ...

journal_title：eLife

authors： Belin BJ,Lee T,Mullins RD

更新日期：2015-08-19 00:00:00

abstract：:Previously we identified Lam/GramD1 proteins, a family of endoplasmic reticulum membrane proteins with sterol-binding StARkin domains that are implicated in intracellular sterol homeostasis. Here, we show how these proteins exchange sterol molecules with membranes. An aperture at one end of the StARkin domain enables ...

journal_title：eLife

authors： Khelashvili G,Chauhan N,Pandey K,Eliezer D,Menon AK

更新日期：2019-12-04 00:00:00

abstract：:The equilibrium between proliferation and quiescence of myogenic progenitor and stem cells is tightly regulated to ensure appropriate skeletal muscle growth and repair. The non-receptor tyrosine phosphatase Ptpn11 (Shp2) is an important transducer of growth factor and cytokine signals. Here we combined complex genetic...

journal_title：eLife

authors： Griger J,Schneider R,Lahmann I,Schöwel V,Keller C,Spuler S,Nazare M,Birchmeier C

更新日期：2017-05-02 00:00:00

abstract：:Understanding how fungi specialize on their plant host is crucial for developing sustainable disease control. A traditional, centuries-old rice agro-system of the Yuanyang terraces was used as a model to show that virulence effectors of the rice blast fungus Magnaporthe oryzaeh play a key role in its specialization on...

journal_title：eLife

authors： Liao J,Huang H,Meusnier I,Adreit H,Ducasse A,Bonnot F,Pan L,He X,Kroj T,Fournier E,Tharreau D,Gladieux P,Morel JB

更新日期：2016-12-23 00:00:00

abstract：:A small transparent crustacean called Parhyale hawaiensis has become a powerful model system for the study of limb and appendage regeneration. ...

journal_title：eLife

authors： Amaya E

更新日期：2016-10-25 00:00:00

abstract：:Deinococcus radiodurans (DR) survives in the presence of hundreds of double-stranded DNA (dsDNA) breaks by efficiently repairing such breaks. RecO, a protein that is essential for the extreme radioresistance of DR, is one of the major recombination mediator proteins in the RecA-loading process in the RecFOR pathway. H...

journal_title：eLife

authors： Hwang J,Kim JY,Kim C,Park S,Joo S,Kim SK,Lee NK

更新日期：2020-04-16 00:00:00

abstract：:The anterior cingulate cortex (ACC) encodes information supporting mnemonic and cognitive processes. We show here that a rat's position can be decoded with high spatiotemporal resolution from ACC activity. ACC neurons encoded the current state of the animal and task, except for brief excursions that sometimes occurred...

journal_title：eLife

authors： Mashhoori A,Hashemnia S,McNaughton BL,Euston DR,Gruber AJ

更新日期：2018-04-17 00:00:00

abstract：:Over 80% of multiple-tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death characterized by simultaneous activation of multiple cell death pathways preferentially killing transformed and cancer stem cells. We now show these si/shRNAs kill cancer cells through canonical RNAi by targ...

journal_title：eLife

authors： Putzbach W,Gao QQ,Patel M,van Dongen S,Haluck-Kangas A,Sarshad AA,Bartom ET,Kim KA,Scholtens DM,Hafner M,Zhao JC,Murmann AE,Peter ME

更新日期：2017-10-24 00:00:00

abstract：:There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction. In this study, using single-session extinction trai...

journal_title：eLife

authors： An B,Kim J,Park K,Lee S,Song S,Choi S

更新日期：2017-07-03 00:00:00

abstract：:Oomycete pathogens secrete host cell-entering effector proteins to manipulate host immunity during infection. We previously showed that PsAvh52, an early-induced RxLR effector secreted from the soybean root rot pathogen, Phytophthora sojae, could suppress plant immunity. Here, we found that PsAvh52 is required for ful...

journal_title：eLife

authors： Li H,Wang H,Jing M,Zhu J,Guo B,Wang Y,Lin Y,Chen H,Kong L,Ma Z,Wang Y,Ye W,Dong S,Tyler B,Wang Y

更新日期：2018-10-22 00:00:00

abstract：:Alzheimer's and Parkinson's disease are late onset neurodegenerative diseases that will require therapy over decades to mitigate the effects of disease-driving proteins such tau and α-synuclein (α-Syn). Previously we found that TRIM28 regulates the levels and toxicity of α-Syn and tau (journal_title：eLife

authors： Rousseaux MW,Revelli JP,Vázquez-Vélez GE,Kim JY,Craigen E,Gonzales K,Beckinghausen J,Zoghbi HY

更新日期：2018-06-04 00:00:00

abstract：:Aging is an intricate phenomenon associated with the gradual loss of physiological functions, and both nutrient sensing and proteostasis control lifespan. Although multiple approaches have facilitated the identification of candidate genes that govern longevity, the molecular mechanisms that link aging pathways are sti...

journal_title：eLife

authors： Chen YC,Jiang PH,Chen HM,Chen CH,Wang YT,Chen YJ,Yu CJ,Teng SC

更新日期：2018-12-05 00:00:00

abstract：:New data on the relationship between two proteins, cyclin D and Rb, suggest that we need to re-evaluate our understanding of how cells enter into the cell cycle. ...

journal_title：eLife

authors： Bertoli C,de Bruin RA

更新日期：2014-07-01 00:00:00

abstract：:Hawaiian isolates of the nematode species Caenorhabditis elegans have long been known to harbor genetic diversity greater than the rest of the worldwide population, but this observation was supported by only a small number of wild strains. To better characterize the niche and genetic diversity of Hawaiian C. elegans a...

journal_title：eLife

authors： Crombie TA,Zdraljevic S,Cook DE,Tanny RE,Brady SC,Wang Y,Evans KS,Hahnel S,Lee D,Rodriguez BC,Zhang G,van der Zwagg J,Kiontke K,Andersen EC

更新日期：2019-12-03 00:00:00

abstract：:Whether neurons encode information through their spike rates, their activity times or both is an ongoing debate in systems neuroscience. Here, we tested whether humans can discriminate between a pair of temporal odor mixtures (TOMs) composed of the same two components delivered in rapid succession in either one tempor...

journal_title：eLife

authors： Perl O,Nahum N,Belelovsky K,Haddad R

更新日期：2020-02-07 00:00:00

abstract：:Rising and more variable global temperatures pose a challenge for biodiversity, with reproduction and fertility being especially sensitive to heat. Here, we assessed the potential for thermal adaptation in sperm and egg function using Tribolium flour beetles, a warm-temperate-tropical insect model. Following temperatu...

journal_title：eLife

authors： Vasudeva R,Sutter A,Sales K,Dickinson ME,Lumley AJ,Gage MJ

更新日期：2019-10-01 00:00:00

abstract：:The new open-access journal eLife has launched, making its first content available in PubMed Central. In addition to publishing science of the highest quality, the journal aims to improve both the peer-review process and the presentation of new research results. ...

journal_title：eLife

authors： Schekman R,Patterson M,Watt F,Weigel D

更新日期：2012-10-15 00:00:00

abstract：:A founding paradigm in virology is that the spatial unit of the viral replication cycle is an individual cell. Multipartite viruses have a segmented genome where each segment is encapsidated separately. In this situation the viral genome is not recapitulated in a single virus particle but in the viral population. How ...

journal_title：eLife

authors： Sicard A,Pirolles E,Gallet R,Vernerey MS,Yvon M,Urbino C,Peterschmitt M,Gutierrez S,Michalakis Y,Blanc S

更新日期：2019-03-12 00:00:00

abstract：:Group B Streptococcus (GBS) is the leading cause of invasive bacterial neonatal infections. Late-onset diseases (LOD) occur between 7 and 89 days of life and are largely due to the CC17 GBS hypervirulent clone. We studied the impact of estradiol (E2) and progesterone (P4), which impregnate the fetus during pregnancy, ...

journal_title：eLife

authors： Hays C,Touak G,Bouaboud A,Fouet A,Guignot J,Poyart C,Tazi A

更新日期：2019-11-11 00:00:00

abstract：:We wish to identify determinants of endothelial lineage. Murine embryonic stem cells (mESC) were fused with human endothelial cells in stable, non-dividing, heterokaryons. Using RNA-seq, it is possible to discriminate between human and mouse transcripts in these chimeric heterokaryons. We observed a temporal pattern o...

journal_title：eLife

authors： Wong WT,Matrone G,Tian X,Tomoiaga SA,Au KF,Meng S,Yamazoe S,Sieveking D,Chen K,Burns DM,Chen JK,Blau HM,Cooke JP

更新日期：2017-03-21 00:00:00

abstract：:Apical secretion from epithelial tubes of the Drosophila embryo is mediated by apical F-actin cables generated by the formin-family protein Diaphanous (Dia). Apical localization and activity of Dia are at the core of restricting F-actin formation to the correct membrane domain. Here we identify the mechanisms that tar...

journal_title：eLife

authors： Rousso T,Shewan AM,Mostov KE,Schejter ED,Shilo BZ

更新日期：2013-07-09 00:00:00

abstract：:Multiple studies have reported a male bias in incidence and/or prevalence of malaria infection in males compared to females. To test the hypothesis that sex-based differences in host-parasite interactions affect the epidemiology of malaria, we intensively followed Plasmodium falciparum infections in a cohort in a mala...

journal_title：eLife

authors： Briggs J,Teyssier N,Nankabirwa JI,Rek J,Jagannathan P,Arinaitwe E,Bousema T,Drakeley C,Murray M,Crawford E,Hathaway N,Staedke SG,Smith D,Rosenthal PJ,Kamya M,Dorsey G,Rodriguez-Barraquer I,Greenhouse B

更新日期：2020-10-27 00:00:00

abstract：:Host-virus arms races are inherently asymmetric; viruses evolve much more rapidly than host genomes. Thus, there is high interest in discovering mechanisms by which host genomes keep pace with rapidly evolving viruses. One family of restriction factors, the APOBEC3 (A3) cytidine deaminases, has undergone positive sele...

journal_title：eLife

authors： Yang L,Emerman M,Malik HS,McLaughlin RN Jnr

更新日期：2020-06-01 00:00:00