Abstract:
:Alzheimer's and Parkinson's disease are late onset neurodegenerative diseases that will require therapy over decades to mitigate the effects of disease-driving proteins such tau and α-synuclein (α-Syn). Previously we found that TRIM28 regulates the levels and toxicity of α-Syn and tau (
journal_name
Elifejournal_title
eLifeauthors
Rousseaux MW,Revelli JP,Vázquez-Vélez GE,Kim JY,Craigen E,Gonzales K,Beckinghausen J,Zoghbi HYdoi
10.7554/eLife.36768subject
Has Abstractpub_date
2018-06-04 00:00:00issn
2050-084Xpii
36768journal_volume
7pub_type
杂志文章相关文献
eLife文献大全abstract::Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolites relative to the time needed to isolate cells. To overcome this cha...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56782
更新日期:2020-07-10 00:00:00
abstract:: ...
journal_title:eLife
pub_type: 已发布勘误
doi:10.7554/eLife.66683
更新日期:2021-01-25 00:00:00
abstract::Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic airway disease, subfertility, ectopic pregnancy, and hydrocephalus. While many patients harbor mutations in the dynein motors that drive cilia beating, the disease also results from mutations in so-called dynein axonemal ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.38497
更新日期:2018-12-18 00:00:00
abstract::A fluorescent imaging technique called fastFISH has been used to track the various steps involved in the transcription of a single DNA molecule. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.02061
更新日期:2014-01-01 00:00:00
abstract::The immediate evolutionary space accessible to HIV is largely determined by how single amino acid mutations affect fitness. These mutational effects can shift as the virus evolves. However, the prevalence of such shifts in mutational effects remains unclear. Here, we quantify the effects on viral growth of all amino a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34420
更新日期:2018-03-28 00:00:00
abstract::Development of specialized cells and structures in the heart is regulated by spatially -restricted molecular pathways. Disruptions in these pathways can cause severe congenital cardiac malformations or functional defects. To better understand these pathways and how they regulate cardiac development we used tomo-seq, c...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.31515
更新日期:2018-02-05 00:00:00
abstract::Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies. Here, we demonstrate engineering of electrically and chemically responsive, contractile human muscle tissues ('myobundles') using primar...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04885
更新日期:2015-01-09 00:00:00
abstract::The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase. Until now, the regulation that restricts CMG ubiquitylation to terminatio...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.60371
更新日期:2020-08-17 00:00:00
abstract::SUMO1-conjugation of proteins at neuronal synapses is considered to be a major post-translational regulatory process in nerve cell and synapse function, but the published evidence for SUMO1-conjugation at synapses is contradictory. We employed multiple genetic mouse models for stringently controlled biochemical and im...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26338
更新日期:2017-06-09 00:00:00
abstract::The phylogenetic placement of the morphologically simple placozoans is crucial to understanding the evolution of complex animal traits. Here, we examine the influence of adding new genomes from placozoans to a large dataset designed to study the deepest splits in the animal phylogeny. Using site-heterogeneous substitu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36278
更新日期:2018-10-30 00:00:00
abstract::Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of simulations. However, the number of published models, and the lack of standardization, make the comparison of ion channel models with one another and with experimental dat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22152
更新日期:2017-03-06 00:00:00
abstract::Toothed whales use sonar to detect, locate, and track prey. They adjust emitted sound intensity, auditory sensitivity and click rate to target range, and terminate prey pursuits with high-repetition-rate, low-intensity buzzes. However, their narrow acoustic field of view (FOV) is considered stable throughout target ap...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.05651
更新日期:2015-03-20 00:00:00
abstract::In eukaryotes, intra-chromosomal recombination generates DNA circles, but little is known about how cells react to them. In yeast, partitioning of such circles to the mother cell at mitosis ensures their loss from the population but promotes replicative ageing. Nevertheless, the mechanisms of partitioning are debated....
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03790
更新日期:2014-11-17 00:00:00
abstract::To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away from biotin after enrichment, and a spacer arm that can be label...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12509
更新日期:2016-03-08 00:00:00
abstract::PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But late-LTP and memory are maintained without PKMζ in PKMζ-null mice. Two hypotheses can account for these findings. First, PKMζ is unimportant for LTP or memory. Second, PKMζ is essential for late-LTP and long-term memory i...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14846
更新日期:2016-05-17 00:00:00
abstract::Struggling to get her research project up and running in a new country, a mother gets inspiration from her young daughter. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59587
更新日期:2020-06-10 00:00:00
abstract::Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocy...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25903
更新日期:2017-05-16 00:00:00
abstract::Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, Perforin-2 prevents the intracellular replication and proliferation of bacterial pathogens in these cells. Perfori...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.06508
更新日期:2015-09-24 00:00:00
abstract::Hepcidin is the master regulator of systemic iron homeostasis. Derived primarily from the liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of iron absorption and recycling respectively. Recently, we demonstrated that ferroportin is also found in cardiomyocytes, and that its cardiac-spe...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.19804
更新日期:2016-11-29 00:00:00
abstract::Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and within, post-synaptic densities (PSDs) from rats. Organic fluorescent...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27744
更新日期:2017-07-27 00:00:00
abstract::B-cell receptors form ordered clusters to recruit kinases and exclude phosphatases. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.25375
更新日期:2017-03-30 00:00:00
abstract::Selective autophagy is mediated by cargo receptors that link the cargo to the isolation membrane via interactions with Atg8 proteins. Atg8 proteins are localized to the membrane in an ubiquitin-like conjugation reaction, but how this conjugation is coupled to the presence of the cargo is unclear. Here we show that the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.18544
更新日期:2016-11-23 00:00:00
abstract::Initiatives to improve research communication can benefit from listening to graduate students, postdocs and newly-independent group leaders. ...
journal_title:eLife
pub_type: 社论
doi:10.7554/eLife.36263
更新日期:2018-03-27 00:00:00
abstract::Lissencephaly ('smooth brain') is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease - lissencephaly-1 (LIS1) - has been a focus of intense scrutiny since its first identification almost 30 years ago. LIS1 is a criti...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59737
更新日期:2020-07-21 00:00:00
abstract::Systemic metabolic reprogramming induced by infection exerts profound, pathogen-specific effects on infection outcome. Here, we detail the host immune and metabolic response during sickness and recovery in a mouse model of malaria. We describe extensive alterations in metabolism during acute infection, and identify in...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.60165
更新日期:2020-10-06 00:00:00
abstract::Ribosomes are universally important in biology and their production is dysregulated by developmental disorders, cancer, and virus infection. Although presumed required for protein synthesis, how ribosome biogenesis impacts virus reproduction and cell-intrinsic immune responses remains untested. Surprisingly, we find t...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49551
更新日期:2019-12-16 00:00:00
abstract::As part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Blum et al., 2015), that described how we intended to replicate selected experiments from the paper 'Transcriptional amplification in tumor cells with elevated c-Myc' (Lin et al., 2012). Here we report the results. We found overe...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30274
更新日期:2018-01-09 00:00:00
abstract::Establishing how neurocircuit activation causes particular behaviors requires modulating the activity of specific neurons. Here, we demonstrate that magnetothermal genetic stimulation provides tetherless deep brain activation sufficient to evoke motor behavior in awake mice. The approach uses alternating magnetic fiel...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27069
更新日期:2017-08-15 00:00:00
abstract::Motor fatigability emerges when demanding tasks are executed over an extended period of time. Here, we used repetitive low-force movements that cause a gradual reduction in movement speed (or 'motor slowing') to study the central component of fatigability in healthy adults. We show that motor slowing is associated wit...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46750
更新日期:2019-09-16 00:00:00
abstract::Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling and cell division. We show that mechanical strain induced Src-depe...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.19799
更新日期:2016-10-26 00:00:00