Abstract:
:Establishing how neurocircuit activation causes particular behaviors requires modulating the activity of specific neurons. Here, we demonstrate that magnetothermal genetic stimulation provides tetherless deep brain activation sufficient to evoke motor behavior in awake mice. The approach uses alternating magnetic fields to heat superparamagnetic nanoparticles on the neuronal membrane. Neurons, heat-sensitized by expressing TRPV1 are activated with magnetic field application. Magnetothermal genetic stimulation in the motor cortex evoked ambulation, deep brain stimulation in the striatum caused rotation around the body-axis, and stimulation near the ridge between ventral and dorsal striatum caused freezing-of-gait. The duration of the behavior correlated tightly with field application. This approach provides genetically and spatially targetable, repeatable and temporarily precise activation of deep-brain circuits without the need for surgical implantation of any device.
journal_name
Elifejournal_title
eLifeauthors
Munshi R,Qadri SM,Zhang Q,Castellanos Rubio I,Del Pino P,Pralle Adoi
10.7554/eLife.27069subject
Has Abstractpub_date
2017-08-15 00:00:00issn
2050-084Xpii
27069journal_volume
6pub_type
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