相关文献
eLife文献大全abstract::Cortical plasticity is fundamental to motor recovery following cortical perturbation. However, it is still unclear how this plasticity is induced at a functional circuit level. Here, we investigated motor recovery and underlying neural plasticity upon optogenetic suppression of a cortical area for eye movement. Using ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50855
更新日期:2019-11-05 00:00:00
abstract::Clinical trials are currently underway to assess the efficacy of forniceal deep brain stimulation (DBS) for improvement of memory in Alzheimer's patients, and forniceal DBS has been shown to improve learning and memory in a mouse model of Rett syndrome (RTT), an intellectual disability disorder caused by loss-of-funct...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34031
更新日期:2018-03-23 00:00:00
abstract::Appropriate generalization of learned responses to new situations is vital for adaptive behavior. We provide a circuit-level account of generalization in the electrosensory lobe (ELL) of weakly electric mormyrid fish. Much is already known in this system about a form of learning in which motor corollary discharge sign...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44032
更新日期:2019-03-14 00:00:00
abstract::An individual may need to take different actions to the same stimulus in different situations to achieve a given goal. The selection of the appropriate action hinges on the previously learned associations between stimuli, actions, and outcomes in the situations. Here, using a go/no-go paradigm and a symmetrical reward...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.43281
更新日期:2019-04-04 00:00:00
abstract::Humans and other animals base important decisions on estimates of number, and intraparietal cortex is thought to provide a crucial substrate of this ability. However, it remains debated whether an independent neuronal processing mechanism underlies this 'number sense', or whether number is instead judged indirectly on...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.45160
更新日期:2019-07-24 00:00:00
abstract::The characteristics of goal-directed actions tend to resemble those of previously executed actions, but it is unclear whether such effects depend strictly on action history, or also reflect context-dependent processes related to predictive motor planning. Here we manipulated the time available to initiate movements af...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26713
更新日期:2017-10-23 00:00:00
abstract::Cerebellar climbing fiber activity encodes performance errors during many motor learning tasks, but the role of these error signals in learning has been controversial. We compared two motor learning paradigms that elicited equally robust putative error signals in the same climbing fibers: learned increases and decreas...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02076
更新日期:2014-04-22 00:00:00
abstract::Compartmentalized oscillations of second messengers affect global cellular signaling. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.63845
更新日期:2020-11-17 00:00:00
abstract::The mesiotemporal lobe (MTL) is implicated in many cognitive processes, is compromised in numerous brain disorders, and exhibits a gradual cytoarchitectural transition from six-layered parahippocampal isocortex to three-layered hippocampal allocortex. Leveraging an ultra-high-resolution histological reconstruction of ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.60673
更新日期:2020-11-04 00:00:00
abstract::Despite their importance in sexual differentiation and reproduction, Y chromosome genes are rarely described because they reside in repeat-rich regions that are difficult to study. Here, we show that Guy1, a unique Y chromosome gene of a major urban malaria mosquito Anopheles stephensi, confers 100% female lethality w...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.19281
更新日期:2016-09-20 00:00:00
abstract::Cardiac conduction defects decrease life expectancy in myotonic dystrophy type 1 (DM1), a CTG repeat disorder involving misbalance between two RNA binding factors, MBNL1 and CELF1. However, how DM1 condition translates into conduction disorders remains poorly understood. Here we simulated MBNL1 and CELF1 misbalance in...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51114
更新日期:2019-12-12 00:00:00
abstract::The training of PhD students and early-career scientists is largely an apprenticeship in which the trainee associates with an expert to become an independent scientist. But when is a PhD student ready to graduate, a postdoctoral scholar ready for an independent position, or an early-career scientist ready for advanced...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34801
更新日期:2018-05-31 00:00:00
abstract::Efficient precision genome engineering requires high frequency and specificity of integration at the genomic target site. Here, we describe a set of resources to streamline reporter gene knock-ins in zebrafish and demonstrate the broader utility of the method in mammalian cells. Our approach uses short homology of 24-...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53968
更新日期:2020-05-15 00:00:00
abstract::Our understanding of the antigen presentation pathway has recently been enhanced with the identification that the tapasin-related protein TAPBPR is a second major histocompatibility complex (MHC) class I-specific chaperone. We sought to determine whether, like tapasin, TAPBPR can also influence MHC class I peptide sel...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09617
更新日期:2015-10-06 00:00:00
abstract::Struggling to get her research project up and running in a new country, a mother gets inspiration from her young daughter. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59587
更新日期:2020-06-10 00:00:00
abstract::A polymorphism in the autophagy gene Atg16l1 is associated with susceptibility to inflammatory bowel disease (IBD); however, it remains unclear how autophagy contributes to intestinal immune homeostasis. Here, we demonstrate that autophagy is essential for maintenance of balanced CD4(+) T cell responses in the intesti...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12444
更新日期:2016-02-24 00:00:00
abstract::Microbes are embedded in complex communities where they engage in a wide array of intra- and inter-specific interactions. The extent to which these interactions drive or impede microbiome diversity is not well understood. Historically, two contrasting hypotheses have been suggested to explain how species interactions ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58999
更新日期:2020-11-20 00:00:00
abstract::Faithful chromosome segregation in all eukaryotes relies on centromeres, the chromosomal sites that recruit kinetochore proteins and mediate spindle attachment during cell division. The centromeric histone H3 variant, CenH3, is the defining chromatin component of centromeres in most eukaryotes, including animals, fung...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03676
更新日期:2014-09-23 00:00:00
abstract::Mitochondria are dynamic organelles that must precisely control their protein composition according to cellular energy demand. Although nuclear-encoded mRNAs can be localized to the mitochondrial surface, the importance of this localization is unclear. As yeast switch to respiratory metabolism, there is an increase in...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57814
更新日期:2020-08-07 00:00:00
abstract::Stem cells are maintained in a specialized microenvironment called niche but the nature of stem cell niche remains poorly defined in many systems. Here we demonstrate that intestinal epithelium-derived BMP serves as a niche signal for intestinal stem cell (ISC) self-renewal in Drosophila adult midgut. We find that BMP...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01857
更新日期:2014-03-11 00:00:00
abstract::Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo β-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is proposed to be the sole e...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39865
更新日期:2018-12-03 00:00:00
abstract::Precise and efficient manipulation of genes is crucial for understanding the molecular mechanisms that govern human hematopoiesis and for developing novel therapies for diseases of the blood and immune system. Current methods do not enable precise engineering of complex genotypes that can be easily tracked in a mixed ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27873
更新日期:2017-09-28 00:00:00
abstract::Bacterial cells utilize monitoring substrates, which undergo force-sensitive translation elongation arrest, to feedback-regulate a Sec-related gene. Vibrio alginolyticus VemP controls the expression of SecD/F that stimulates a late step of translocation by undergoing export-regulated elongation arrest. Here, we attemp...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.62623
更新日期:2020-12-15 00:00:00
abstract::AMPARs control fast synaptic communication between neurons and their function relies on auxiliary subunits, which importantly modulate channel properties. Although it has been suggested that AMPARs can bind to TARPs with variable stoichiometry, little is known about the effect that this stoichiometry exerts on certain...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53946
更新日期:2020-05-26 00:00:00
abstract::Embryonic polarity of invertebrates, amphibians and fish is specified largely by maternal determinants, which fixes cell fates early in development. In contrast, amniote embryos remain plastic and can form multiple individuals until gastrulation. How is their polarity determined? In the chick embryo, the earliest know...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03743
更新日期:2014-12-11 00:00:00
abstract::Kinesin super family protein 2A (KIF2A), an ATP-dependent microtubule (MT) destabilizer, regulates cell migration, axon elongation, and pruning in the developing nervous system. KIF2A mutations have recently been identified in patients with malformed cortical development. However, postnatal KIF2A is continuously expre...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30935
更新日期:2018-01-09 00:00:00
abstract::Experiments on mitochondrial DNA in worms highlight that cheating does not always pay off. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.62222
更新日期:2020-09-22 00:00:00
abstract::Across species, sleep in young animals is critical for normal brain maturation. The molecular determinants of early life sleep remain unknown. Through an RNAi-based screen, we identified a gene, pdm3, required for sleep maturation in Drosophila. Pdm3, a transcription factor, coordinates an early developmental program ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52676
更新日期:2020-03-23 00:00:00
abstract::Optogenetic approaches are leading to a better understanding of the forces that determine the plane of cell division. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.38748
更新日期:2018-07-09 00:00:00
abstract::Accurate protein localization is crucial to generate and maintain organization in all cells. Achieving accuracy is challenging, as the molecular signals that dictate a protein's cellular destination are often promiscuous. A salient example is the targeting of an essential class of tail-anchored (TA) proteins, whose so...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21301
更新日期:2016-12-07 00:00:00