Gating of neural error signals during motor learning.

Abstract:

:Cerebellar climbing fiber activity encodes performance errors during many motor learning tasks, but the role of these error signals in learning has been controversial. We compared two motor learning paradigms that elicited equally robust putative error signals in the same climbing fibers: learned increases and decreases in the gain of the vestibulo-ocular reflex (VOR). During VOR-increase training, climbing fiber activity on one trial predicted changes in cerebellar output on the next trial, and optogenetic activation of climbing fibers to mimic their encoding of performance errors was sufficient to implant a motor memory. In contrast, during VOR-decrease training, there was no trial-by-trial correlation between climbing fiber activity and changes in cerebellar output, and climbing fiber activation did not induce VOR-decrease learning. Our data suggest that the ability of climbing fibers to induce plasticity can be dynamically gated in vivo, even under conditions where climbing fibers are robustly activated by performance errors. DOI: http://dx.doi.org/10.7554/eLife.02076.001.

journal_name

Elife

journal_title

eLife

authors

Kimpo RR,Rinaldi JM,Kim CK,Payne HL,Raymond JL

doi

10.7554/eLife.02076

subject

Has Abstract

pub_date

2014-04-22 00:00:00

pages

e02076

issn

2050-084X

journal_volume

3

pub_type

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