Action history influences subsequent movement via two distinct processes.

abstract：:A heat exchange mechanism in the head of kissing bugs helps to prevent stress and regulate their temperature while they feed on warm blood. ...

journal_title：eLife

authors： Benoit JB,Denlinger DL

更新日期：2017-11-21 00:00:00

abstract：:Decisions are accompanied by a degree of confidence that a selected option is correct. A sequential sampling framework explains the speed and accuracy of decisions and extends naturally to the confidence that the decision rendered is likely to be correct. However, discrepancies between confidence and accuracy suggest ...

journal_title：eLife

authors： van den Berg R,Anandalingam K,Zylberberg A,Kiani R,Shadlen MN,Wolpert DM

更新日期：2016-02-01 00:00:00

abstract：:A key challenge in antibiotic stewardship is figuring out how to use antibiotics therapeutically without promoting the evolution of antibiotic resistance. Here, we demonstrate proof of concept for an adjunctive therapy that allows intravenous antibiotic treatment without driving the evolution and onward transmission o...

journal_title：eLife

authors： Morley VJ,Kinnear CL,Sim DG,Olson SN,Jackson LM,Hansen E,Usher GA,Showalter SA,Pai MP,Woods RJ,Read AF

更新日期：2020-12-01 00:00:00

abstract：:Recent transcriptional profiling technologies are uncovering previously-undefined cell populations and molecular markers at an unprecedented pace. While single cell RNA (scRNA) sequencing is an attractive approach for unbiased transcriptional profiling of all cell types, a complementary method to isolate and sequence ...

journal_title：eLife

authors： Amamoto R,Garcia MD,West ER,Choi J,Lapan SW,Lane EA,Perrimon N,Cepko CL

更新日期：2019-12-09 00:00:00

abstract：:Although mRNAs are localized in the processes of excitatory neurons, it is still unclear whether interneurons also localize a large population of mRNAs. In addition, the variability in the localized mRNA population within and between cell types is unknown. Here we describe the unbiased transcriptomic characterization ...

journal_title：eLife

authors： Perez JD,Dieck ST,Alvarez-Castelao B,Tushev G,Chan IC,Schuman EM

更新日期：2021-01-06 00:00:00

abstract：:The progenitor cells of the developing liver can differentiate toward both hepatocyte and biliary cell fates. In addition to the established roles of TGFβ and Notch signaling in this fate specification process, there is increasing evidence that liver progenitors are sensitive to mechanical cues. Here, we utilized micr...

journal_title：eLife

authors： Kaylan KB,Berg IC,Biehl MJ,Brougham-Cook A,Jain I,Jamil SM,Sargeant LH,Cornell NJ,Raetzman LT,Underhill GH

更新日期：2018-12-27 00:00:00

abstract：:A pair of neurons is required for nematodes to be able to navigate using the Earth's magnetic field. ...

journal_title：eLife

authors： Rankin CH,Lin CH

更新日期：2015-08-05 00:00:00

abstract：:We previously showed in Drosophila melanogaster embryos that low-affinity Ultrabithorax (Ubx)-responsive shavenbaby (svb) enhancers drive expression using localized transcriptional environments and that active svb enhancers on different chromosomes tended to colocalize (Tsai et al., 2017). Here, we test the hypothesis...

journal_title：eLife

authors： Tsai A,Alves MR,Crocker J

更新日期：2019-07-11 00:00:00

abstract：:To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away from biotin after enrichment, and a spacer arm that can be label...

journal_title：eLife

authors： Tan D,Li Q,Zhang MJ,Liu C,Ma C,Zhang P,Ding YH,Fan SB,Tao L,Yang B,Li X,Ma S,Liu J,Feng B,Liu X,Wang HW,He SM,Gao N,Ye K,Dong MQ,Lei X

更新日期：2016-03-08 00:00:00

abstract：:Swi2/Snf2 ATPases remodel substrates such as nucleosomes and transcription complexes to control a wide range of DNA-associated processes, but detailed structural information on the ATP-dependent remodeling reactions is largely absent. The single subunit remodeler Mot1 (modifier of transcription 1) dissociates TATA box...

journal_title：eLife

authors： Butryn A,Schuller JM,Stoehr G,Runge-Wollmann P,Förster F,Auble DT,Hopfner KP

更新日期：2015-08-10 00:00:00

abstract：:Cancer prevention is predicted to result in more positive therapeutic outcomes than post-diagnostic interventions, and so may be a viable option for future personalized medicine. ...

journal_title：eLife

authors： Komarova NL

更新日期：2015-08-05 00:00:00

abstract：:TMEM16A is a ligand-gated anion channel that is activated by intracellular Ca2+. This channel comprises two independent pores and closely apposed Ca2+ binding sites that are contained within each subunit of a homodimeric protein. Previously we characterized the influence of positively charged pore-lining residues on a...

journal_title：eLife

authors： Lam AK,Dutzler R

更新日期：2018-10-12 00:00:00

abstract：:Numerous brain regions have been shown to have neural correlates of gradually accumulating evidence for decision-making, but the causal roles of these regions in decisions driven by accumulation of evidence have yet to be determined. Here, in rats performing an auditory evidence accumulation task, we inactivated the f...

journal_title：eLife

authors： Erlich JC,Brunton BW,Duan CA,Hanks TD,Brody CD

更新日期：2015-04-14 00:00:00

abstract：:Cell-type-specific 3D organization of the genome is unrecognizable during mitosis. It remains unclear how essential positional information is transmitted through cell division such that a daughter cell recapitulates the spatial genome organization of the parent. Lamina-associated domains (LADs) are regions of repressi...

journal_title：eLife

authors： Poleshko A,Smith CL,Nguyen SC,Sivaramakrishnan P,Wong KG,Murray JI,Lakadamyali M,Joyce EF,Jain R,Epstein JA

更新日期：2019-10-01 00:00:00

abstract：:Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can undergo irreversible aggregation to the amyloid state. The dimer...

journal_title：eLife

authors： Brumshtein B,Esswein SR,Salwinski L,Phillips ML,Ly AT,Cascio D,Sawaya MR,Eisenberg DS

更新日期：2015-11-18 00:00:00

abstract：:In vivo, the primary molecular mechanotransductive events mechanically initiating cell differentiation remain unknown. Here we find the molecular stretching of the highly conserved Y654-β-catenin-D665-E-cadherin binding site as mechanically induced by tissue strain. It triggers the increase of accessibility of the Y65...

journal_title：eLife

authors： Röper JC,Mitrossilis D,Stirnemann G,Waharte F,Brito I,Fernandez-Sanchez ME,Baaden M,Salamero J,Farge E

更新日期：2018-07-19 00:00:00

abstract：:During early embryogenesis, cells must exit pluripotency and commit to multiple lineages in all germ-layers. How this transition is operated in vivo is poorly understood. Here, we report that MEK1 and the Nanog-related transcription factor Ventx2 coordinate this transition. MEK1 was required to make Xenopus pluripoten...

journal_title：eLife

authors： Scerbo P,Marchal L,Kodjabachian L

更新日期：2017-06-27 00:00:00

abstract：:RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein aggregates or through phase separation into a liquid RNA/protein phase. Which model describes RNP granules in living cells is still unclear. In this study, we analyze P bodies in budding yeast and find that they have liquid-like pro...

journal_title：eLife

authors： Kroschwald S,Maharana S,Mateju D,Malinovska L,Nüske E,Poser I,Richter D,Alberti S

更新日期：2015-08-04 00:00:00

abstract：:Mu-opioid receptors (MORs) are crucial for analgesia by both exogenous and endogenous opioids. However, the distinct mechanisms underlying these two types of opioid analgesia remain largely unknown. Here, we demonstrate that analgesic effects of exogenous and endogenous opioids on inflammatory pain are mediated by MOR...

journal_title：eLife

authors： Zhang XY,Dou YN,Yuan L,Li Q,Zhu YJ,Wang M,Sun YG

更新日期：2020-06-10 00:00:00

abstract：:A key hallmark of visual perceptual awareness is robustness to instabilities arising from unnoticeable eye and eyelid movements. In previous human intracranial (iEEG) work (Golan et al., 2016) we found that excitatory broadband high-frequency activity transients, driven by eye blinks, are suppressed in higher-level bu...

journal_title：eLife

authors： Golan T,Davidesco I,Meshulam M,Groppe DM,Mégevand P,Yeagle EM,Goldfinger MS,Harel M,Melloni L,Schroeder CE,Deouell LY,Mehta AD,Malach R

更新日期：2017-08-29 00:00:00

abstract：:Unfolded protein responses (UPRs) safeguard cellular function during proteotoxic stress and aging. In a previous paper (Lehrbach and Ruvkun, 2016) we showed that the ER-associated SKN-1A/Nrf1 transcription factor activates proteasome subunit expression in response to proteasome dysfunction, but it was not established ...

journal_title：eLife

authors： Lehrbach NJ,Ruvkun G

更新日期：2019-04-11 00:00:00

abstract：:Transcription at individual genes in single cells is often pulsatile and stochastic. A key question emerges regarding how this behaviour contributes to tissue phenotype, but it has been a challenge to quantitatively analyse this in living cells over time, as opposed to studying snap-shots of gene expression state. We ...

journal_title：eLife

authors： Featherstone K,Hey K,Momiji H,McNamara AV,Patist AL,Woodburn J,Spiller DG,Christian HC,McNeilly AS,Mullins JJ,Finkenstädt BF,Rand DA,White MR,Davis JR

更新日期：2016-02-01 00:00:00

abstract：:The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury. Here, we report novel pathways in axon regeneration, identified by extending our previous function-based screen using the C. elegans...

journal_title：eLife

authors： Kim KW,Tang NH,Piggott CA,Andrusiak MG,Park S,Zhu M,Kurup N,Cherra SJ 3rd,Wu Z,Chisholm AD,Jin Y

更新日期：2018-11-21 00:00:00

abstract：:Embryonic polarity of invertebrates, amphibians and fish is specified largely by maternal determinants, which fixes cell fates early in development. In contrast, amniote embryos remain plastic and can form multiple individuals until gastrulation. How is their polarity determined? In the chick embryo, the earliest know...

journal_title：eLife

authors： Torlopp A,Khan MA,Oliveira NM,Lekk I,Soto-Jiménez LM,Sosinsky A,Stern CD

更新日期：2014-12-11 00:00:00

abstract：:Most funding agencies rely on peer review to evaluate grant applications and proposals, but research into the use of this process by funding agencies has been limited. Here we explore if two changes to the organization of peer review for proposals submitted to various funding actions by the European Union has an influ...

journal_title：eLife

authors： Pina DG,Buljan I,Hren D,Marušić A

更新日期：2021-01-13 00:00:00

abstract：:Tissue elongation and its control by spatiotemporal signals is a major developmental question. Currently, it is thought that Drosophila ovarian follicular epithelium elongation requires the planar polarization of the basal domain cytoskeleton and of the extra-cellular matrix, associated with a dynamic process of rotat...

journal_title：eLife

authors： Alégot H,Pouchin P,Bardot O,Mirouse V

更新日期：2018-02-08 00:00:00

abstract：:The germ line provides the cellular link between generations of multicellular organisms, its cells entering the meiotic cell cycle only once each generation. However, the mechanisms governing this initiation of meiosis remain poorly understood. Here, we examined cells undergoing meiotic initiation in mice, and we foun...

journal_title：eLife

authors： Kojima ML,de Rooij DG,Page DC

更新日期：2019-02-27 00:00:00

abstract：:Signals delivered by costimulatory molecules are implicated in driving T cell expansion. The requirements for these signals, however, vary from dispensable to essential in different infections. We examined the underlying mechanisms of this differential T cell costimulation dependence and found that the viral context d...

journal_title：eLife

authors： Welten SP,Redeker A,Franken KL,Oduro JD,Ossendorp F,Čičin-Šain L,Melief CJ,Aichele P,Arens R

更新日期：2015-08-11 00:00:00

abstract：:The vascular pathogen Verticillium dahliae infects the roots of plants to cause Verticillium wilt. The molecular mechanisms underlying V. dahliae virulence and host resistance remain elusive. Here, we demonstrate that a secretory protein, VdSCP41, functions as an intracellular effector that promotes V. dahliae virulen...

journal_title：eLife

authors： Qin J,Wang K,Sun L,Xing H,Wang S,Li L,Chen S,Guo HS,Zhang J

更新日期：2018-05-14 00:00:00

abstract：:In 2015, as part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Kandela et al., 2015) that described how we intended to replicate selected experiments from the paper "BET bromodomain inhibition as a therapeutic strategy to target c-Myc" (Delmore et al., 2011). Here we report the resu...

journal_title：eLife

authors： Aird F,Kandela I,Mantis C,Reproducibility Project: Cancer Biology.

更新日期：2017-01-19 00:00:00