Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements.

abstract：:Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease. Consensus in the field has been that expression of these factors likely reflects the target cell of transformation rather than being required for continued tumor growt...

journal_title：eLife

authors： Tenente IM,Hayes MN,Ignatius MS,McCarthy K,Yohe M,Sindiri S,Gryder B,Oliveira ML,Ramakrishnan A,Tang Q,Chen EY,Petur Nielsen G,Khan J,Langenau DM

更新日期：2017-01-12 00:00:00

abstract：:Why does a first pregnancy after age 35 increase the risk of breast cancer, and what can be done to combat this? ...

journal_title：eLife

authors： Chakravarthi BV,Varambally S

更新日期：2013-12-31 00:00:00

abstract：:Neoangiogenesis is a pivotal therapeutic target in glioblastoma. Tumor monitoring requires imaging methods to assess treatment effects and disease progression. Until now mapping of the tumor vasculature has been difficult. We have developed a combined magnetic resonance and optical toolkit to study neoangiogenesis in ...

journal_title：eLife

authors： Breckwoldt MO,Bode J,Kurz FT,Hoffmann A,Ochs K,Ott M,Deumelandt K,Krüwel T,Schwarz D,Fischer M,Helluy X,Milford D,Kirschbaum K,Solecki G,Chiblak S,Abdollahi A,Winkler F,Wick W,Platten M,Heiland S,Bendszus M,Tews

更新日期：2016-02-02 00:00:00

abstract：:The ellipsoid body (EB) in the Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination functions. However, what regulates R axon lamination and how lamination affects R neuron function re...

journal_title：eLife

authors： Xie X,Tabuchi M,Brown MP,Mitchell SP,Wu MN,Kolodkin AL

更新日期：2017-06-20 00:00:00

abstract：:Genomic rearrangements associated with speciation often result in variation in chromosome number among closely related species. Malassezia species show variable karyotypes ranging between six and nine chromosomes. Here, we experimentally identified all eight centromeres in M. sympodialis as 3-5-kb long kinetochore-bou...

journal_title：eLife

authors： Sankaranarayanan SR,Ianiri G,Coelho MA,Reza MH,Thimmappa BC,Ganguly P,Vadnala RN,Sun S,Siddharthan R,Tellgren-Roth C,Dawson TL Jnr,Heitman J,Sanyal K

更新日期：2020-01-20 00:00:00

abstract：:Our understanding of the antigen presentation pathway has recently been enhanced with the identification that the tapasin-related protein TAPBPR is a second major histocompatibility complex (MHC) class I-specific chaperone. We sought to determine whether, like tapasin, TAPBPR can also influence MHC class I peptide sel...

journal_title：eLife

authors： Hermann C,van Hateren A,Trautwein N,Neerincx A,Duriez PJ,Stevanović S,Trowsdale J,Deane JE,Elliott T,Boyle LH

更新日期：2015-10-06 00:00:00

abstract：:Apical secretion from epithelial tubes of the Drosophila embryo is mediated by apical F-actin cables generated by the formin-family protein Diaphanous (Dia). Apical localization and activity of Dia are at the core of restricting F-actin formation to the correct membrane domain. Here we identify the mechanisms that tar...

journal_title：eLife

authors： Rousso T,Shewan AM,Mostov KE,Schejter ED,Shilo BZ

更新日期：2013-07-09 00:00:00

abstract：:We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface. The nature of this interface coupled with quantitative analysis of deletion mutants of H2A-H2B suggests that the N...

journal_title：eLife

authors： Padavannil A,Sarkar P,Kim SJ,Cagatay T,Jiou J,Brautigam CA,Tomchick DR,Sali A,D'Arcy S,Chook YM

更新日期：2019-03-11 00:00:00

abstract：:Generating recombinant monoclonal antibodies (R-mAbs) from mAb-producing hybridomas offers numerous advantages that increase the effectiveness, reproducibility, and transparent reporting of research. We report here the generation of a novel resource in the form of a library of recombinant R-mAbs validated for neurosci...

journal_title：eLife

authors： Andrews NP,Boeckman JX,Manning CF,Nguyen JT,Bechtold H,Dumitras C,Gong B,Nguyen K,van der List D,Murray KD,Engebrecht J,Trimmer JS

更新日期：2019-01-22 00:00:00

abstract：:Understanding how genes and experience work in concert to generate phenotypic variability will provide a better understanding of individuality. Here, we considered this in the main olfactory epithelium, a chemosensory structure with over a thousand distinct cell types in mice. We identified a subpopulation of olfactor...

journal_title：eLife

authors： Vihani A,Hu XS,Gundala S,Koyama S,Block E,Matsunami H

更新日期：2020-11-24 00:00:00

abstract：:Mitochondria support synaptic transmission through production of ATP, sequestration of calcium, synthesis of glutamate, and other vital functions. Surprisingly, less than 50% of hippocampal CA1 presynaptic boutons contain mitochondria, raising the question of whether synapses without mitochondria can sustain changes i...

journal_title：eLife

authors： Smith HL,Bourne JN,Cao G,Chirillo MA,Ostroff LE,Watson DJ,Harris KM

更新日期：2016-12-19 00:00:00

abstract：:The characteristics of goal-directed actions tend to resemble those of previously executed actions, but it is unclear whether such effects depend strictly on action history, or also reflect context-dependent processes related to predictive motor planning. Here we manipulated the time available to initiate movements af...

journal_title：eLife

authors： Marinovic W,Poh E,de Rugy A,Carroll TJ

更新日期：2017-10-23 00:00:00

abstract：:Host-virus arms races are inherently asymmetric; viruses evolve much more rapidly than host genomes. Thus, there is high interest in discovering mechanisms by which host genomes keep pace with rapidly evolving viruses. One family of restriction factors, the APOBEC3 (A3) cytidine deaminases, has undergone positive sele...

journal_title：eLife

authors： Yang L,Emerman M,Malik HS,McLaughlin RN Jnr

更新日期：2020-06-01 00:00:00

abstract：:Regulation of protein turnover allows cells to react to their environment and maintain homeostasis. Proteins can show different turnover rates in different tissue, but little is known about protein turnover in different brain cell types. We used dynamic SILAC to determine half-lives of over 5100 proteins in rat primar...

journal_title：eLife

authors： Dörrbaum AR,Kochen L,Langer JD,Schuman EM

更新日期：2018-06-19 00:00:00

abstract：:Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed mas...

journal_title：eLife

authors： Gregorova M,Morse D,Brignoli T,Steventon J,Hamilton F,Albur M,Arnold D,Thomas M,Halliday A,Baum H,Rice C,Avison MB,Davidson AD,Santopaolo M,Oliver E,Goenka A,Finn A,Wooldridge L,Amulic B,Boyton RJ,Altmann DM,But

更新日期：2020-12-17 00:00:00

abstract：:LAMP1 and LAMP2 proteins are highly abundant, ubiquitous, mammalian proteins that line the lysosome limiting membrane, and protect it from lysosomal hydrolase action. LAMP2 deficiency causes Danon's disease, an X-linked hypertrophic cardiomyopathy. LAMP2 is needed for chaperone-mediated autophagy, and its expression i...

journal_title：eLife

authors： Li J,Pfeffer SR

更新日期：2016-09-24 00:00:00

abstract：:Mapping polyclonal serum responses is critical to rational vaccine design. However, most high-resolution mapping approaches involve isolating and characterizing individual antibodies, which incompletely defines the polyclonal response. Here we use two complementary approaches to directly map the specificities of the n...

journal_title：eLife

authors： Dingens AS,Pratap P,Malone KD,Hilton SK,Ketas T,Cottrell CA,Overbaugh JM,Moore JP,Klasse PJ,Ward AB,Bloom JD

更新日期：2021-01-13 00:00:00

abstract：:Nucleolar protein interacting with the FHA domain of pKi-67 (NIFK) is a Ki-67-interacting protein. However, its precise function in cancer remains largely uninvestigated. Here we show the clinical significance and metastatic mechanism of NIFK in lung cancer. NIFK expression is clinically associated with poor prognosis...

journal_title：eLife

authors： Lin TC,Su CY,Wu PY,Lai TC,Pan WA,Jan YH,Chang YC,Yeh CT,Chen CL,Ger LP,Chang HT,Yang CJ,Huang MS,Liu YP,Lin YF,Shyy JY,Tsai MD,Hsiao M

更新日期：2016-03-17 00:00:00

abstract：:Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolites relative to the time needed to isolate cells. To overcome this cha...

journal_title：eLife

authors： Lau AN,Li Z,Danai LV,Westermark AM,Darnell AM,Ferreira R,Gocheva V,Sivanand S,Lien EC,Sapp KM,Mayers JR,Biffi G,Chin CR,Davidson SM,Tuveson DA,Jacks T,Matheson NJ,Yilmaz O,Vander Heiden MG

更新日期：2020-07-10 00:00:00

abstract：:During mitosis chromosomes reorganise into highly compact, rod-shaped forms, thought to consist of consecutive chromatin loops around a central protein scaffold. Condensin complexes are involved in chromatin compaction, but the contribution of other chromatin proteins, DNA sequence and histone modifications is less un...

journal_title：eLife

authors： Fitz-James MH,Tong P,Pidoux AL,Ozadam H,Yang L,White SA,Dekker J,Allshire RC

更新日期：2020-09-11 00:00:00

abstract：:Single-molecule experiments reveal the dynamics of transcription through a nucleosome with single-base-pair accuracy. ...

journal_title：eLife

authors： de Jong BE,van Noort J

更新日期：2019-09-13 00:00:00

abstract：:A transcription factor that regulates skeleton formation in sea urchin embryos has evolved a new domain that is essential for this process. ...

journal_title：eLife

authors： Burke RD

更新日期：2018-01-08 00:00:00

abstract：:A hallmark of CRISPR-Cas immunity systems is the CRISPR array, a genomic locus consisting of short, repeated sequences ('repeats') interspersed with short, variable sequences ('spacers'). CRISPR arrays are transcribed and processed into individual CRISPR RNAs that each include a single spacer, and direct Cas proteins ...

journal_title：eLife

authors： Stringer AM,Baniulyte G,Lasek-Nesselquist E,Seed KD,Wade JT

更新日期：2020-10-30 00:00:00

abstract：:Human patients carrying PAPP-A2 inactivating mutations have low bone mineral density. The underlying mechanisms for this reduced calcification are poorly understood. Using a zebrafish model, we report that Papp-aa regulates bone calcification by promoting Ca2+-transporting epithelial cell (ionocyte) quiescence-prolife...

journal_title：eLife

authors： Liu C,Li S,Noer PR,Kjaer-Sorensen K,Juhl AK,Goldstein A,Ke C,Oxvig C,Duan C

更新日期：2020-04-16 00:00:00

abstract：:Experiments on Drosophila have shown that the histones that are normally bound to lipid droplets inside cells can be released to provide protection against infection. ...

journal_title：eLife

authors： Kolter R

更新日期：2012-11-13 00:00:00

abstract：:Certain neuron types fire spontaneously at high rates, an ability that is crucial for their function in brain circuits. The spontaneously active GABAergic neurons of the substantia nigra pars reticulata (SNr), a major output of the basal ganglia, provide tonic inhibition of downstream brain areas. A depolarizing 'leak...

journal_title：eLife

authors： Lutas A,Lahmann C,Soumillon M,Yellen G

更新日期：2016-05-13 00:00:00

abstract：:How producers of public goods persist in microbial communities is a major question in evolutionary biology. Cooperation is evolutionarily unstable, since cheating strains can reproduce quicker and take over. Spatial structure has been shown to be a robust mechanism for the evolution of cooperation. Here we study how s...

journal_title：eLife

authors： Uppal G,Vural DC

更新日期：2018-05-22 00:00:00

abstract：:Eukaryotic small ribosomal subunits are first assembled into 90S pre-ribosomes. The complete 90S is a gigantic complex with a molecular mass of approximately five megadaltons. Here, we report the nearly complete architecture of Saccharomyces cerevisiae 90S determined from three cryo-electron microscopy single particle...

journal_title：eLife

authors： Sun Q,Zhu X,Qi J,An W,Lan P,Tan D,Chen R,Wang B,Zheng S,Zhang C,Chen X,Zhang W,Chen J,Dong MQ,Ye K

更新日期：2017-02-28 00:00:00

abstract：:Experiments in which monkeys have to select or estimate the location of a target are revealing more about the role of the dorsal premotor cortex in decision making. ...

journal_title：eLife

authors： Stuphorn V

更新日期：2016-07-15 00:00:00

abstract：:We reveal a novel mechanism that explains how preparatory activity can evolve in motor-related cortical areas without prematurely inducing movement. The smooth eye movement region of the frontal eye fields (FEFSEM) is a critical node in the neural circuit controlling smooth pursuit eye movement. Preparatory activity e...

journal_title：eLife

authors： Darlington TR,Lisberger SG

更新日期：2020-02-21 00:00:00