Abstract:
:The new open-access journal eLife has launched, making its first content available in PubMed Central. In addition to publishing science of the highest quality, the journal aims to improve both the peer-review process and the presentation of new research results.
journal_name
Elifejournal_title
eLifeauthors
Schekman R,Patterson M,Watt F,Weigel Ddoi
10.7554/eLife.00270subject
Has Abstractpub_date
2012-10-15 00:00:00pages
e00270issn
2050-084Xpii
00270journal_volume
1pub_type
杂志文章相关文献
eLife文献大全abstract::A pair of neurons is required for nematodes to be able to navigate using the Earth's magnetic field. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.09666
更新日期:2015-08-05 00:00:00
abstract::Plasmodium sporozoites, the mosquito-transmitted forms of the malaria parasite, first infect the liver for an initial round of replication before the emergence of pathogenic blood stages. Sporozoites represent attractive targets for antimalarial preventive strategies, yet the mechanisms of parasite entry into hepatocy...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25903
更新日期:2017-05-16 00:00:00
abstract::Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control signals. We show that cortical maturation requires a reduction in cortical porosity, and a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56666
更新日期:2020-05-27 00:00:00
abstract::The neural correlates of consciousness are typically sought by comparing the overall brain responses to perceived and unperceived stimuli. However, this comparison may be contaminated by non-specific attention, alerting, performance, and reporting confounds. Here, we pursue a novel approach, tracking the neuronal codi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.05652
更新日期:2015-05-21 00:00:00
abstract::Studies of cell fate focus on specification, but little is known about maintenance of the differentiated state. In this study, we find that the mouse tendon cell fate requires continuous maintenance in vivo and identify an essential role for TGFβ signaling in maintenance of the tendon cell fate. To examine the role of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52695
更新日期:2020-01-21 00:00:00
abstract::Delineating the basic cellular components of cortical inhibitory circuits remains a fundamental issue in order to understand their specific contributions to microcircuit function. It is still unclear how current classifications of cortical interneuron subtypes relate to biological processes such as their developmental...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.32017
更新日期:2018-03-20 00:00:00
abstract::How living systems break symmetry in an organized manner is a fundamental question in biology. In wild-type Caenorhabditis elegans zygotes, symmetry breaking during anterior-posterior axis specification is guided by centrosomes, resulting in anterior-directed cortical flows and a single posterior PAR-2 domain. We unco...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44552
更新日期:2019-02-26 00:00:00
abstract::Cancer cells usually exhibit aberrant cell signaling and metabolic reprogramming. However, mechanisms of crosstalk between these processes remain elusive. Here, we show that in an in vivo tumor model expressing oncogenic Drosophila Homeodomain-interacting protein kinase (Hipk), tumor cells display elevated aerobic gly...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46315
更新日期:2019-07-01 00:00:00
abstract::We collated contact tracing data from COVID-19 clusters in Singapore and Tianjin, China and estimated the extent of pre-symptomatic transmission by estimating incubation periods and serial intervals. The mean incubation periods accounting for intermediate cases were 4.91 days (95%CI 4.35, 5.69) and 7.54 (95%CI 6.76, 8...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57149
更新日期:2020-06-22 00:00:00
abstract::Cognitive control proactively configures information processing to suit expected task demands. Predictions of forthcoming demand can be driven by explicit external cues or be generated internally, based on past experience (cognitive history). However, it is not known whether and how the brain reconciles these two sour...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39497
更新日期:2018-08-16 00:00:00
abstract::B-cell receptors form ordered clusters to recruit kinases and exclude phosphatases. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.25375
更新日期:2017-03-30 00:00:00
abstract::The neuronal DNA-/RNA-binding protein Pur-alpha is a transcription regulator and core factor for mRNA localization. Pur-alpha-deficient mice die after birth with pleiotropic neuronal defects. Here, we report the crystal structure of the DNA-/RNA-binding domain of Pur-alpha in complex with ssDNA. It reveals base-specif...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11297
更新日期:2016-01-08 00:00:00
abstract::Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-ra...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39111
更新日期:2018-12-25 00:00:00
abstract::Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In Drosophila, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional understanding of the LH is scant, in large part due to a lack of sparse neurogenetic t...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.43079
更新日期:2019-05-21 00:00:00
abstract::Antiviral development is plagued by drug resistance and genetic barriers to resistance are needed. For HIV and hepatitis C virus (HCV), combination therapy has proved life-saving. The targets of direct-acting antivirals for HCV infection are NS3/4A protease, NS5A phosphoprotein and NS5B polymerase. Differential visual...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.32579
更新日期:2018-03-28 00:00:00
abstract::Down syndrome (DS) results in various degrees of cognitive deficits. In DS mouse models, recovery of behavioral and neurophysiological deficits using GABAAR antagonists led to hypothesize an excessive activity of inhibitory circuits in this condition. Nonetheless, whether over-inhibition is present in DS and whether t...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58731
更新日期:2020-08-12 00:00:00
abstract::Cell fate decisions are critical for life, yet little is known about how their reliability is achieved when signals are noisy and fluctuating with time. In this study, we show that in budding yeast, the decision of cell cycle commitment (Start) is determined by the time integration of its triggering signal Cln3. We fu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03977
更新日期:2015-01-14 00:00:00
abstract::Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose availability or the energy sensor AMP-activat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51063
更新日期:2019-12-23 00:00:00
abstract::Two different cell signals often affect transcription of the same gene. In such cases, it is natural to ask how the combined transcriptional response compares to the individual responses. The most commonly used mechanistic models predict additive or multiplicative combined responses, but a systematic genome-wide evalu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59388
更新日期:2020-12-07 00:00:00
abstract::The growth of preprints in the life sciences has been reported widely and is driving policy changes for journals and funders, but little quantitative information has been published about preprint usage. Here, we report how we collected and analyzed data on all 37,648 preprints uploaded to bioRxiv.org, the largest biol...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.45133
更新日期:2019-04-24 00:00:00
abstract::Msp1 is a conserved AAA ATPase in budding yeast localized to mitochondria where it prevents accumulation of mistargeted tail-anchored (TA) proteins, including the peroxisomal TA protein Pex15. Msp1 also resides on peroxisomes but it remains unknown how native TA proteins on mitochondria and peroxisomes evade Msp1 surv...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.28507
更新日期:2017-09-14 00:00:00
abstract::Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P2-activated, Na+-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the channel activity of TPC1 is strongly dependent on membrane volta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51423
更新日期:2019-12-11 00:00:00
abstract::Numerous brain regions have been shown to have neural correlates of gradually accumulating evidence for decision-making, but the causal roles of these regions in decisions driven by accumulation of evidence have yet to be determined. Here, in rats performing an auditory evidence accumulation task, we inactivated the f...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.05457
更新日期:2015-04-14 00:00:00
abstract::The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been implicated in a wide variety of behavioral and neurological disorders. The DRN is subdivided into distinct anatomical subregions comprised of multiple cell types, and its complex cellular organization has impeded efforts to investiga...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46464
更新日期:2019-08-14 00:00:00
abstract::bicoid mRNA localises to the Drosophila oocyte anterior from stage 9 of oogenesis onwards to provide a local source for Bicoid protein for embryonic patterning. Live imaging at stage 9 reveals that bicoid mRNA particles undergo rapid Dynein-dependent movements near the oocyte anterior, but with no directional bias. Fu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.17537
更新日期:2016-10-28 00:00:00
abstract::Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelle...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25014
更新日期:2017-06-30 00:00:00
abstract::Numerous links exist between co-transcriptional RNA processing and the transcribing RNAPII. In particular, pre-mRNA splicing was reported to be associated with slowed RNAPII elongation. Here, we identify a site of ubiquitination (K1246) in the catalytic subunit of RNAPII close to the DNA entry path. Ubiquitination was...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27082
更新日期:2017-10-13 00:00:00
abstract::In endoplasmic reticulum-associated protein degradation (ERAD), membrane proteins are ubiquitinated, extracted from the membrane, and degraded by the proteasome. The cytosolic ATPase Cdc48 drives extraction by pulling on polyubiquitinated substrates. How hydrophobic transmembrane (TM) segments are moved from the phosp...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56945
更新日期:2020-06-26 00:00:00
abstract::Physiological adaptation to proteotoxic stress in the endoplasmic reticulum (ER) requires retrotranslocation of misfolded proteins into the cytoplasm for ubiquitination and elimination by ER-associated degradation (ERAD). A surprising paradox emerging from recent studies is that ubiquitin ligases (E3s) and deubiquitin...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01369
更新日期:2014-01-01 00:00:00
abstract::Sex-optimal diets have different effects on gene expression in female and male flies. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.51289
更新日期:2019-10-01 00:00:00