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eLife文献大全abstract::The spliceosome is a complex machine composed of small nuclear ribonucleoproteins (snRNPs) and accessory proteins that excises introns from pre-mRNAs. After assembly the spliceosome is activated for catalysis by rearrangement of subunits to form an active site. How this rearrangement is coordinated is not well-underst...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14166
更新日期:2016-05-31 00:00:00
abstract::Autoinducers are small signaling molecules that mediate intercellular communication in microbial populations and trigger coordinated gene expression via 'quorum sensing'. Elucidating the mechanisms that control autoinducer production is, thus, pertinent to understanding collective microbial behavior, such as virulence...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25773
更新日期:2017-07-25 00:00:00
abstract::Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis. Ndst1+ OLG ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51735
更新日期:2020-06-09 00:00:00
abstract::Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Here we identify causes underlying hybrid infertility of two recently diverged fission yeast species Schizosaccharomyces pombe and S. kambucha, which mate to form viable hybrid diploids that effici...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02630
更新日期:2014-06-24 00:00:00
abstract::Canonical transient receptor potential channels (TRPC) are involved in receptor-operated and/or store-operated Ca2+ signaling. Inhibition of TRPCs by small molecules was shown to be promising in treating renal diseases. In cells, the channels are regulated by calmodulin (CaM). Molecular details of both CaM and drug bi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.60603
更新日期:2020-11-25 00:00:00
abstract::The internal brain dynamics that link sensation and action are arguably better studied during natural animal behaviors. Here, we report on a novel volume imaging and 3D tracking technique that monitors whole brain neural activity in freely swimming larval zebrafish (Danio rerio). We demonstrated the capability of our ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.28158
更新日期:2017-09-20 00:00:00
abstract::Meibum lipids form a lipid layer on the outermost side of the tear film and function to prevent water evaporation and reduce surface tension. (O-Acyl)-ω-hydroxy fatty acids (OAHFAs), a subclass of these lipids, are thought to be involved in connecting the lipid and aqueous layers in tears, although their actual functi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53582
更新日期:2020-04-07 00:00:00
abstract::In plants the dorsoventral boundary of leaves defines an axis of symmetry through the centre of the organ separating the top (dorsal) and bottom (ventral) tissues. Although the positioning of this boundary is critical for leaf morphogenesis, how the boundary is established and how it influences development remains unc...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27421
更新日期:2017-09-12 00:00:00
abstract::During inflammation, serum amyloid A proteins transport retinol to infected tissues. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.04246
更新日期:2014-09-02 00:00:00
abstract::The ellipsoid body (EB) in the Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination functions. However, what regulates R axon lamination and how lamination affects R neuron function re...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25328
更新日期:2017-06-20 00:00:00
abstract::We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture pas...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58042
更新日期:2020-08-24 00:00:00
abstract::Journals are exploring new approaches to peer review in order to reduce bias, increase transparency and respond to author preferences. Funders are also getting involved. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.32011
更新日期:2017-09-29 00:00:00
abstract::Researchers have identified two genes-follistatin and activin-as having an important role in the ability of certain flatworms to identify wounds that require the production of new tissue. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.00533
更新日期:2013-09-10 00:00:00
abstract::Previous studies had shown that the integration of genome wide expression profiles, in metabolic tissues, with genetic and phenotypic variance, provided valuable insight into the underlying molecular mechanisms. We used RNA-Seq to characterize hypothalamic transcriptome in 99 inbred strains of mice from the Hybrid Mou...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.15614
更新日期:2016-09-13 00:00:00
abstract::Mature microRNAs (miRNAs) are processed from primary transcripts (pri-miRNAs), and their expression is controlled at transcriptional and post-transcriptional levels. However, how regulation at multiple levels achieves precise control remains elusive. Using published and new datasets, we profile a time course of mature...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.38389
更新日期:2018-07-19 00:00:00
abstract::The enteric nervous system controls a variety of gastrointestinal functions including intestinal motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but several intestinal regions display also other motility patterns for which the underlying circuits and connectivity schemes th...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.42914
更新日期:2019-02-12 00:00:00
abstract::Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is presented, the most relevant memory should be updated. In a contextual version of the object recogniti...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.33746
更新日期:2018-05-02 00:00:00
abstract::Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-ra...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39111
更新日期:2018-12-25 00:00:00
abstract::Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.53233
更新日期:2019-12-06 00:00:00
abstract::Advanced microscopy and labeling techniques reveal that bacteria localize mRNAs within their cells in a similar way to eukaryotes. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.16598
更新日期:2016-05-20 00:00:00
abstract::PKMζ is a persistently active PKC isoform proposed to maintain late-LTP and long-term memory. But late-LTP and memory are maintained without PKMζ in PKMζ-null mice. Two hypotheses can account for these findings. First, PKMζ is unimportant for LTP or memory. Second, PKMζ is essential for late-LTP and long-term memory i...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14846
更新日期:2016-05-17 00:00:00
abstract::Segmentation of the axial skeleton in amniotes depends on the segmentation clock, which patterns the paraxial mesoderm and the sclerotome. While the segmentation clock clearly operates in teleosts, the role of the sclerotome in establishing the axial skeleton is unclear. We severely disrupt zebrafish paraxial segmenta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.33843
更新日期:2018-04-06 00:00:00
abstract::Interaction between disease-microbiome associations and ageing has not been explored in detail. Here, using age/region-matched sub-sets, we analysed the gut microbiome differences across five major diseases in a multi-cohort dataset constituting more than 2500 individuals from 20 to 89 years old. We show that disease-...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50240
更新日期:2020-03-11 00:00:00
abstract::Axonal conduction velocity can change substantially during ongoing activity, thus modifying spike interval structures and, potentially, temporal coding. We used a biophysical model to unmask mechanisms underlying the history-dependence of conduction. The model replicates activity in the unmyelinated axon of the crusta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25382
更新日期:2017-07-10 00:00:00
abstract::To efficiently navigate through the environment and avoid potential threats, an animal must quickly detect the motion of approaching objects. Current models of primate vision place the origins of this complex computation in the visual cortex. Here, we report that detection of approaching motion begins in the retina. S...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51144
更新日期:2020-02-24 00:00:00
abstract::Early mouse development is accompanied by dynamic changes in chromatin modifications, including G9a-mediated histone H3 lysine 9 dimethylation (H3K9me2), which is essential for embryonic development. Here we show that genome-wide accumulation of H3K9me2 is crucial for postimplantation development, and coincides with r...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09571
更新日期:2015-11-09 00:00:00
abstract::Learning more about the cells that enable parasitic worms called schistosomes to reproduce inside snails could lead to new treatments that prevent these parasites from being transmitted to humans. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.01115
更新日期:2013-07-30 00:00:00
abstract::T follicular helper cells (Tfh) are critical for the longevity and quality of antibody-mediated protection against infection. Yet few signaling pathways have been identified to be unique solely to Tfh development. ROQUIN is a post-transcriptional repressor of T cells, acting through its ROQ domain to destabilize mRNA ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.08698
更新日期:2015-10-23 00:00:00
abstract::Deinococcus radiodurans (DR) survives in the presence of hundreds of double-stranded DNA (dsDNA) breaks by efficiently repairing such breaks. RecO, a protein that is essential for the extreme radioresistance of DR, is one of the major recombination mediator proteins in the RecA-loading process in the RecFOR pathway. H...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50945
更新日期:2020-04-16 00:00:00
abstract::WNK1, a kinase that controls kidney salt homeostasis, also regulates adhesion and migration in CD4+ T cells. Wnk1 is highly expressed in thymocytes, and since migration is important for thymocyte maturation, we investigated a role for WNK1 in mouse thymocyte development. We find that WNK1 is required for the transitio...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56934
更新日期:2020-10-14 00:00:00