Abstract:
:Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is presented, the most relevant memory should be updated. In a contextual version of the object recognition task, we examined the effect of medial PFC (mPFC) serotonin 2a receptor (5-HT2aR) blockade during retrieval in reconsolidation of competing objects memories. We found that mPFC 5-HT2aR controls retrieval and reconsolidation of object memories in the perirhinal cortex (PRH), but not in the dorsal hippocampus in rats. Also, reconsolidation of objects memories in PRH required a functional interaction between the ventral hippocampus and the mPFC. Our results indicate that in the presence of conflicting information at retrieval, mPFC 5-HT2aR may facilitate top-down context-guided control over PRH to control the behavioral response and object memory reconsolidation.
journal_name
Elifejournal_title
eLifeauthors
Morici JF,Miranda M,Gallo FT,Zanoni B,Bekinschtein P,Weisstaub NVdoi
10.7554/eLife.33746subject
Has Abstractpub_date
2018-05-02 00:00:00issn
2050-084Xpii
33746journal_volume
7pub_type
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