Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine.

abstract：:The representation of position in the mammalian brain is distributed across multiple neural populations. Grid cell modules in the medial entorhinal cortex (MEC) express activity patterns that span a low-dimensional manifold which remains stable across different environments. In contrast, the activity patterns of hippo...

journal_title：eLife

authors： Agmon H,Burak Y

更新日期：2020-08-11 00:00:00

abstract：:Genome-wide association analyses have uncovered multiple genomic regions associated with T2D, but identification of the causal variants at these remains a challenge. There is growing interest in the potential of deep learning models - which predict epigenome features from DNA sequence - to support inference concerning...

journal_title：eLife

authors： Wesolowska-Andersen A,Zhuo Yu G,Nylander V,Abaitua F,Thurner M,Torres JM,Mahajan A,Gloyn AL,McCarthy MI

更新日期：2020-01-27 00:00:00

abstract：:Apical secretion from epithelial tubes of the Drosophila embryo is mediated by apical F-actin cables generated by the formin-family protein Diaphanous (Dia). Apical localization and activity of Dia are at the core of restricting F-actin formation to the correct membrane domain. Here we identify the mechanisms that tar...

journal_title：eLife

authors： Rousso T,Shewan AM,Mostov KE,Schejter ED,Shilo BZ

更新日期：2013-07-09 00:00:00

abstract：:Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors with mutations in p53 and ATRX, an H3.3-specific chromatin remodeler. To gain insight into the role of H3-G34R, we generated fission yeast that express o...

journal_title：eLife

authors： Yadav RK,Jablonowski CM,Fernandez AG,Lowe BR,Henry RA,Finkelstein D,Barnum KJ,Pidoux AL,Kuo YM,Huang J,O'Connell MJ,Andrews AJ,Onar-Thomas A,Allshire RC,Partridge JF

更新日期：2017-07-18 00:00:00

abstract：:Stem cells are maintained in a specialized microenvironment called niche but the nature of stem cell niche remains poorly defined in many systems. Here we demonstrate that intestinal epithelium-derived BMP serves as a niche signal for intestinal stem cell (ISC) self-renewal in Drosophila adult midgut. We find that BMP...

journal_title：eLife

authors： Tian A,Jiang J

更新日期：2014-03-11 00:00:00

abstract：:The restoration of homeostasis after tissue damage relies on proper spatial-temporal control of damage-induced apoptosis and compensatory proliferation. In Drosophila imaginal discs these processes are coordinated by the stress response pathway JNK. We demonstrate that JNK signaling induces a dose-dependent extension ...

journal_title：eLife

authors： Cosolo A,Jaiswal J,Csordás G,Grass I,Uhlirova M,Classen AK

更新日期：2019-02-08 00:00:00

abstract：:A heat exchange mechanism in the head of kissing bugs helps to prevent stress and regulate their temperature while they feed on warm blood. ...

journal_title：eLife

authors： Benoit JB,Denlinger DL

更新日期：2017-11-21 00:00:00

abstract：:Contrary to dogma, evolutionarily young and dynamic genes can encode essential functions. We find that evolutionarily dynamic ZAD-ZNF genes, which encode the most abundant class of insect transcription factors, are more likely to encode essential functions in Drosophila melanogaster than ancient, conserved ZAD-ZNF gen...

journal_title：eLife

authors： Kasinathan B,Colmenares SU 3rd,McConnell H,Young JM,Karpen GH,Malik HS

更新日期：2020-11-10 00:00:00

abstract：:Mitochondrial dysfunction is associated with activation of the integrated stress response (ISR) but the underlying triggers remain unclear. We systematically combined acute mitochondrial inhibitors with genetic tools for compartment-specific NADH oxidation to trace mechanisms linking different forms of mitochondrial d...

journal_title：eLife

authors： Mick E,Titov DV,Skinner OS,Sharma R,Jourdain AA,Mootha VK

更新日期：2020-05-28 00:00:00

abstract：:Group B Streptococcus (GBS) is the leading cause of invasive bacterial neonatal infections. Late-onset diseases (LOD) occur between 7 and 89 days of life and are largely due to the CC17 GBS hypervirulent clone. We studied the impact of estradiol (E2) and progesterone (P4), which impregnate the fetus during pregnancy, ...

journal_title：eLife

authors： Hays C,Touak G,Bouaboud A,Fouet A,Guignot J,Poyart C,Tazi A

更新日期：2019-11-11 00:00:00

abstract：:The final identity of a differentiated neuron is determined by multiple signaling events, including activity dependent calcium transients. Non-canonical Frizzled2 (Fz2) signaling generates calcium transients that determine neuronal polarity, neuronal migration, and synapse assembly in the developing vertebrate brain. ...

journal_title：eLife

authors： Agrawal T,Hasan G

更新日期：2015-05-08 00:00:00

abstract：:Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of axonemes in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a coiled-coil stalk. We address how cytoplasmic and axonemal dynein MTBDs bind microtubules at near a...

journal_title：eLife

authors： Lacey SE,He S,Scheres SH,Carter AP

更新日期：2019-07-02 00:00:00

abstract：:Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod, comprised of repeating FimA subunits, provides a structural scaffold for displaying the tip adhesin, FimH. We solved the 4.2 Å resoluti...

journal_title：eLife

authors： Spaulding CN,Schreiber HL 4th,Zheng W,Dodson KW,Hazen JE,Conover MS,Wang F,Svenmarker P,Luna-Rico A,Francetic O,Andersson M,Hultgren S,Egelman EH

更新日期：2018-01-18 00:00:00

abstract：:K146N is a dominant mutation in human β-cardiac myosin heavy chain, which causes hypertrophic cardiomyopathy. We examined how Drosophila muscle responds to this mutation and integratively analyzed the biochemical, physiological and mechanical foundations of the disease. ATPase assays, actin motility, and indirect flig...

journal_title：eLife

authors： Kronert WA,Bell KM,Viswanathan MC,Melkani GC,Trujillo AS,Huang A,Melkani A,Cammarato A,Swank DM,Bernstein SI

更新日期：2018-08-13 00:00:00

abstract：:Over the past century, soybean oil (SBO) consumption in the United States increased dramatically. The main SBO fatty acid, linoleic acid (18:2), inhibits in vitro the growth of lactobacilli, beneficial members of the small intestinal microbiota. Human-associated lactobacilli have declined in prevalence in Western micr...

journal_title：eLife

authors： Di Rienzi SC,Jacobson J,Kennedy EA,Bell ME,Shi Q,Waters JL,Lawrence P,Brenna JT,Britton RA,Walter J,Ley RE

更新日期：2018-03-27 00:00:00

abstract：:The collapse of iconic, keystone populations of sockeye (Oncorhynchus nerka) and Chinook (Oncorhynchus tshawytscha) salmon in the Northeast Pacific is of great concern. It is thought that infectious disease may contribute to declines, but little is known about viruses endemic to Pacific salmon. Metatranscriptomic sequ...

journal_title：eLife

authors： Mordecai GJ,Miller KM,Di Cicco E,Schulze AD,Kaukinen KH,Ming TJ,Li S,Tabata A,Teffer A,Patterson DA,Ferguson HW,Suttle CA

更新日期：2019-09-03 00:00:00

abstract：:We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism was unknown. Here we show E. faecium has unique peptidoglycan comp...

journal_title：eLife

authors： Kim B,Wang YC,Hespen CW,Espinosa J,Salje J,Rangan KJ,Oren DA,Kang JY,Pedicord VA,Hang HC

更新日期：2019-04-10 00:00:00

abstract：Background:Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is currently unavailable. Here, we explore the use of the well-establishe...

journal_title：eLife

authors： Reuling IJ,van de Schans LA,Coffeng LE,Lanke K,Meerstein-Kessel L,Graumans W,van Gemert GJ,Teelen K,Siebelink-Stoter R,van de Vegte-Bolmer M,de Mast Q,van der Ven AJ,Ivinson K,Hermsen CC,de Vlas S,Bradley J,Collins KA,O

更新日期：2018-02-27 00:00:00

abstract：:Linking interindividual differences in psychological phenotype to variations in brain structure is an old dream for psychology and a crucial question for cognitive neurosciences. Yet, replicability of the previously-reported 'structural brain behavior' (SBB)-associations has been questioned, recently. Here, we conduct...

journal_title：eLife

authors： Kharabian Masouleh S,Eickhoff SB,Hoffstaedter F,Genon S,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2019-03-13 00:00:00

abstract：:Cancer prevention is predicted to result in more positive therapeutic outcomes than post-diagnostic interventions, and so may be a viable option for future personalized medicine. ...

journal_title：eLife

authors： Komarova NL

更新日期：2015-08-05 00:00:00

abstract：:Computational models postulate that head-direction (HD) cells are part of an attractor network integrating head turns. This network requires inputs from visual landmarks to anchor the HD signal to the external world. We investigated whether information about HD and visual landmarks is integrated in the medial entorhin...

journal_title：eLife

authors： Kornienko O,Latuske P,Bassler M,Kohler L,Allen K

更新日期：2018-09-17 00:00:00

abstract：:Heterogeneity broadly exists in various cell types both during development and at homeostasis. Investigating heterogeneity is crucial for comprehensively understanding the complexity of ontogeny, dynamics, and function of specific cell types. Traditional bulk-labeling techniques are incompetent to dissect heterogeneit...

journal_title：eLife

authors： He S,Tian Y,Feng S,Wu Y,Shen X,Chen K,He Y,Sun Q,Li X,Xu J,Wen Z,Qu JY

更新日期：2020-01-06 00:00:00

abstract：:Using a clever combination of genetic and biochemical tools researchers have shown that a transcription factor called USF1 has a central role in determining how mutations of the Clock gene manifest themselves in the behaviour of different mouse strains. ...

journal_title：eLife

authors： Demarque M,Schibler U

更新日期：2013-04-09 00:00:00

abstract：:TCF/LEF factors are ancient context-dependent enhancer-binding proteins that are activated by β-catenin following Wnt signaling. They control embryonic development and adult stem cell compartments, and their dysregulation often causes cancer. β-catenin-dependent transcription relies on the NPF motif of Pygo proteins. ...

journal_title：eLife

authors： Fiedler M,Graeb M,Mieszczanek J,Rutherford TJ,Johnson CM,Bienz M

更新日期：2015-08-27 00:00:00

abstract：:Genetic programming and neural activity drive synaptic remodeling in developing neural circuits, but the molecular components that link these pathways are poorly understood. Here we show that the C. elegans Degenerin/Epithelial Sodium Channel (DEG/ENaC) protein, UNC-8, is transcriptionally controlled to function as a ...

journal_title：eLife

authors： Miller-Fleming TW,Petersen SC,Manning L,Matthewman C,Gornet M,Beers A,Hori S,Mitani S,Bianchi L,Richmond J,Miller DM

更新日期：2016-07-12 00:00:00

abstract：:To elucidate new functions of sphingosine (Sph), we demonstrate that the spontaneous elevation of intracellular Sph levels via caged Sph leads to a significant and transient calcium release from acidic stores that is independent of sphingosine 1-phosphate, extracellular and ER calcium levels. This photo-induced Sph-dr...

journal_title：eLife

authors： Höglinger D,Haberkant P,Aguilera-Romero A,Riezman H,Porter FD,Platt FM,Galione A,Schultz C

更新日期：2015-11-27 00:00:00

abstract：:Variation in the presence or absence of transposable elements (TEs) is a major source of genetic variation between individuals. Here, we identified 23,095 TE presence/absence variants between 216 Arabidopsis accessions. Most TE variants were rare, and we find these rare variants associated with local extremes of gene ...

journal_title：eLife

authors： Stuart T,Eichten SR,Cahn J,Karpievitch YV,Borevitz JO,Lister R

更新日期：2016-12-02 00:00:00

abstract：:Dendritic spines are specialized postsynaptic structures that transduce presynaptic signals, are regulated by neural activity and correlated with learning and memory. Most studies of spine function have focused on the mammalian nervous system. However, spine-like protrusions have been reported in C. elegans (Philbrook...

journal_title：eLife

authors： Cuentas-Condori A,Mulcahy B,He S,Palumbos S,Zhen M,Miller DM 3rd

更新日期：2019-10-04 00:00:00

abstract：:Signals delivered by costimulatory molecules are implicated in driving T cell expansion. The requirements for these signals, however, vary from dispensable to essential in different infections. We examined the underlying mechanisms of this differential T cell costimulation dependence and found that the viral context d...

journal_title：eLife

authors： Welten SP,Redeker A,Franken KL,Oduro JD,Ossendorp F,Čičin-Šain L,Melief CJ,Aichele P,Arens R

更新日期：2015-08-11 00:00:00

abstract：:Mating systems have profound effects on genetic diversity and compatibility. The convergent evolution of self-fertilization in three Caenorhabditis species provides a powerful lens to examine causes and consequences of mating system transitions. Among the selfers, Caenorhabditis tropicalis is the least genetically div...

journal_title：eLife

authors： Noble LM,Yuen J,Stevens L,Moya N,Persaud R,Moscatelli M,Jackson JL,Zhang G,Chitrakar R,Baugh LR,Braendle C,Andersen EC,Seidel HS,Rockman MV

更新日期：2021-01-11 00:00:00