Abstract:
:Variation in the presence or absence of transposable elements (TEs) is a major source of genetic variation between individuals. Here, we identified 23,095 TE presence/absence variants between 216 Arabidopsis accessions. Most TE variants were rare, and we find these rare variants associated with local extremes of gene expression and DNA methylation levels within the population. Of the common alleles identified, two thirds were not in linkage disequilibrium with nearby SNPs, implicating these variants as a source of novel genetic diversity. Many common TE variants were associated with significantly altered expression of nearby genes, and a major fraction of inter-accession DNA methylation differences were associated with nearby TE insertions. Overall, this demonstrates that TE variants are a rich source of genetic diversity that likely plays an important role in facilitating epigenomic and transcriptional differences between individuals, and indicates a strong genetic basis for epigenetic variation.
journal_name
Elifejournal_title
eLifeauthors
Stuart T,Eichten SR,Cahn J,Karpievitch YV,Borevitz JO,Lister Rdoi
10.7554/eLife.20777subject
Has Abstractpub_date
2016-12-02 00:00:00issn
2050-084Xjournal_volume
5pub_type
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