A large gene family in fission yeast encodes spore killers that subvert Mendel's law.

abstract：:Pioneer factors such as Zelda (Zld) help initiate zygotic transcription in Drosophila early embryos, but whether other factors support this dynamic process is unclear. Odd-paired (Opa), a zinc-finger transcription factor expressed at cellularization, controls the transition of genes from pair-rule to segmental pattern...

journal_title：eLife

authors： Koromila T,Gao F,Iwasaki Y,He P,Pachter L,Gergen JP,Stathopoulos A

更新日期：2020-07-23 00:00:00

abstract：:Recent findings indicate a high level of specialization at the level of microcircuits and cell populations within brain structures with regards to the control of fear and anxiety. The hippocampus, however, has been treated as a unitary structure in anxiety and fear research despite mounting evidence that different hip...

journal_title：eLife

authors： Engin E,Smith KS,Gao Y,Nagy D,Foster RA,Tsvetkov E,Keist R,Crestani F,Fritschy JM,Bolshakov VY,Hajos M,Heldt SA,Rudolph U

更新日期：2016-03-14 00:00:00

abstract：:Numerous links exist between co-transcriptional RNA processing and the transcribing RNAPII. In particular, pre-mRNA splicing was reported to be associated with slowed RNAPII elongation. Here, we identify a site of ubiquitination (K1246) in the catalytic subunit of RNAPII close to the DNA entry path. Ubiquitination was...

journal_title：eLife

authors： Milligan L,Sayou C,Tuck A,Auchynnikava T,Reid JE,Alexander R,Alves FL,Allshire R,Spanos C,Rappsilber J,Beggs JD,Kudla G,Tollervey D

更新日期：2017-10-13 00:00:00

abstract：:Optogenetic approaches are leading to a better understanding of the forces that determine the plane of cell division. ...

journal_title：eLife

authors： Serra-Marques A,Dumont S

更新日期：2018-07-09 00:00:00

abstract：:Antagonistic receptive field surrounds are a near-universal property of early sensory processing. A key assumption in many models for retinal ganglion cell encoding is that receptive field surrounds are added only to the fully formed center signal. But anatomical and functional observations indicate that surrounds are...

journal_title：eLife

authors： Turner MH,Schwartz GW,Rieke F

更新日期：2018-09-06 00:00:00

abstract：:The rhythm generating network for breathing must continuously adjust to changing metabolic and behavioral demands. Here, we examined network-based mechanisms in the mouse preBötzinger complex using substance P, a potent excitatory modulator of breathing frequency and stability, as a tool to dissect network properties ...

journal_title：eLife

authors： Baertsch NA,Ramirez JM

更新日期：2019-12-05 00:00:00

abstract：:Mapping polyclonal serum responses is critical to rational vaccine design. However, most high-resolution mapping approaches involve isolating and characterizing individual antibodies, which incompletely defines the polyclonal response. Here we use two complementary approaches to directly map the specificities of the n...

journal_title：eLife

authors： Dingens AS,Pratap P,Malone KD,Hilton SK,Ketas T,Cottrell CA,Overbaugh JM,Moore JP,Klasse PJ,Ward AB,Bloom JD

更新日期：2021-01-13 00:00:00

abstract：:Little is known about venom in young developmental stages of animals. The appearance of toxins and stinging cells during early embryonic stages in the sea anemone Nematostella vectensis suggests that venom is already expressed in eggs and larvae of this species. Here, we harness transcriptomic, biochemical and transge...

journal_title：eLife

authors： Columbus-Shenkar YY,Sachkova MY,Macrander J,Fridrich A,Modepalli V,Reitzel AM,Sunagar K,Moran Y

更新日期：2018-02-09 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been shown to act as important cell biological regulators including cell fate decisions but are often ignored in human genetics. Combining differential lncRNA expression during neuronal lineage induction with copy number variation morbidity maps of a cohort of children with autism sp...

journal_title：eLife

authors： Ang CE,Ma Q,Wapinski OL,Fan S,Flynn RA,Lee QY,Coe B,Onoguchi M,Olmos VH,Do BT,Dukes-Rimsky L,Xu J,Tanabe K,Wang L,Elling U,Penninger JM,Zhao Y,Qu K,Eichler EE,Srivastava A,Wernig M,Chang HY

更新日期：2019-01-10 00:00:00

abstract：:We are writing to comment on the recent study by Olesen et al., 2018 on antibiotic use and antibiotic resistance. ...

journal_title：eLife

authors： Pouwels KB,Butler CC,Robotham JV

更新日期：2019-05-03 00:00:00

abstract：:Whether neurons encode information through their spike rates, their activity times or both is an ongoing debate in systems neuroscience. Here, we tested whether humans can discriminate between a pair of temporal odor mixtures (TOMs) composed of the same two components delivered in rapid succession in either one tempor...

journal_title：eLife

authors： Perl O,Nahum N,Belelovsky K,Haddad R

更新日期：2020-02-07 00:00:00

abstract：:Cell fate decisions are critical for life, yet little is known about how their reliability is achieved when signals are noisy and fluctuating with time. In this study, we show that in budding yeast, the decision of cell cycle commitment (Start) is determined by the time integration of its triggering signal Cln3. We fu...

journal_title：eLife

authors： Liu X,Wang X,Yang X,Liu S,Jiang L,Qu Y,Hu L,Ouyang Q,Tang C

更新日期：2015-01-14 00:00:00

abstract：:Cell growth and/or proliferation may require the reprogramming of metabolic pathways, whereby a switch from oxidative to glycolytic metabolism diverts glycolytic intermediates towards anabolic pathways. Herein, we identify a novel role for TRIM32 in the maintenance of glycolytic flux mediated by biochemical interactio...

journal_title：eLife

authors： Bawa S,Brooks DS,Neville KE,Tipping M,Sagar MA,Kollhoff JA,Chawla G,Geisbrecht BV,Tennessen JM,Eliceiri KW,Geisbrecht ER

更新日期：2020-03-30 00:00:00

abstract：:Actin filaments assemble inside the nucleus in response to multiple cellular perturbations, including heat shock, protein misfolding, integrin engagement, and serum stimulation. We find that DNA damage also generates nuclear actin filaments-detectable by phalloidin and live-cell actin probes-with three characteristic ...

journal_title：eLife

authors： Belin BJ,Lee T,Mullins RD

更新日期：2015-08-19 00:00:00

abstract：:Here, we document a collection of ∼7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to create a library of 400 GFP-tagged genes. We show that 72% of internally tagged proteins are functional, and that more than 90% can be imaged in unfixed tissue...

journal_title：eLife

authors： Nagarkar-Jaiswal S,Lee PT,Campbell ME,Chen K,Anguiano-Zarate S,Gutierrez MC,Busby T,Lin WW,He Y,Schulze KL,Booth BW,Evans-Holm M,Venken KJ,Levis RW,Spradling AC,Hoskins RA,Bellen HJ

更新日期：2015-03-31 00:00:00

abstract：:The Frank-Starling relation is a fundamental auto-regulatory property of the heart that ensures the volume of blood ejected in each heartbeat is matched to the extent of venous filling. At the cellular level, heart muscle cells generate higher force when stretched, but despite intense efforts the underlying molecular ...

journal_title：eLife

authors： Zhang X,Kampourakis T,Yan Z,Sevrieva I,Irving M,Sun YB

更新日期：2017-02-23 00:00:00

abstract：:Combining clonal analysis with a computational agent based model, we investigate how tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE) of the teleost medaka (Oryzias latipes) coordinate their growth rates. NR cell division timing is less variable, consistent with an upstream role...

journal_title：eLife

authors： Tsingos E,Höckendorf B,Sütterlin T,Kirchmaier S,Grabe N,Centanin L,Wittbrodt J

更新日期：2019-03-26 00:00:00

abstract：:Rod and cone photoreceptors are highly similar in many respects but they have important functional and molecular differences. Here, we investigate genome-wide patterns of DNA methylation and chromatin accessibility in mouse rods and cones and correlate differences in these features with gene expression, histone marks,...

journal_title：eLife

authors： Mo A,Luo C,Davis FP,Mukamel EA,Henry GL,Nery JR,Urich MA,Picard S,Lister R,Eddy SR,Beer MA,Ecker JR,Nathans J

更新日期：2016-03-07 00:00:00

abstract：:Temporary circuits amplify spontaneous activity in the visual system of neonatal rats. ...

journal_title：eLife

authors： Fogerson PM,Huguenard JR

更新日期：2016-10-11 00:00:00

abstract：:This study examined records of 2566 consecutive COVID-19 patients at five Massachusetts hospitals and sought to predict level-of-care requirements based on clinical and laboratory data. Several classification methods were applied and compared against standard pneumonia severity scores. The need for hospitalization, IC...

journal_title：eLife

authors： Hao B,Sotudian S,Wang T,Xu T,Hu Y,Gaitanidis A,Breen K,Velmahos GC,Paschalidis IC

更新日期：2020-10-12 00:00:00

abstract：:The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two m...

journal_title：eLife

authors： Patwardhan A,Brandt R,Butcher SJ,Collinson L,Gault D,Grünewald K,Hecksel C,Huiskonen JT,Iudin A,Jones ML,Korir PK,Koster AJ,Lagerstedt I,Lawson CL,Mastronarde D,McCormick M,Parkinson H,Rosenthal PB,Saalfeld S,Saibil

更新日期：2017-07-06 00:00:00

abstract：:The receptor protein Dectin-1 recognizes structures found on cancerous cells, and then triggers an anti-tumor immune response. ...

journal_title：eLife

authors： Okabe Y,Medzhitov R

更新日期：2014-09-24 00:00:00

abstract：:Phenazines are natural bacterial antibiotics that can protect crops from disease. However, for most crops it is unknown which producers and specific phenazines are ecologically relevant, and whether phenazine biodegradation can counter their effects. To better understand their ecology, we developed and environmentally...

journal_title：eLife

authors： Dar D,Thomashow LS,Weller DM,Newman DK

更新日期：2020-09-15 00:00:00

abstract：:A well-established cascade of transcription factor (TF) activity orchestrates adipogenesis in response to chemical cues, yet how cell-intrinsic determinants of differentiation such as cell shape and/or seeding density inform this transcriptional program remain enigmatic. Here, we uncover a novel mechanism licensing tr...

journal_title：eLife

authors： Cohen DM,Won KJ,Nguyen N,Lazar MA,Chen CS,Steger DJ

更新日期：2015-06-25 00:00:00

abstract：:The choroid, which provides vascular supply to the outer retina, demonstrates progressive degeneration in aging and age-related macular degeneration (AMD). However mechanisms that maintain or compromise choroidal homeostasis are obscure. We discovered that the ablation of choroidal macrophages via CSF1R blockade was a...

journal_title：eLife

authors： Yang X,Zhao L,Campos MM,Abu-Asab M,Ortolan D,Hotaling N,Bharti K,Wong WT

更新日期：2020-04-01 00:00:00

abstract：:Humans and animals construct internal models of their environment in order to select appropriate courses of action. The representation of uncertainty about the current state of the environment is a key feature of these models that controls the rate of learning as well as directly affecting choice behaviour. To maintai...

journal_title：eLife

authors： Muller TH,Mars RB,Behrens TE,O'Reilly JX

更新日期：2019-02-28 00:00:00

abstract：:Sequences of events are ubiquitous in sensory, motor, and cognitive function. Key computational operations, including pattern recognition, event prediction, and plasticity, involve neural discrimination of spatio-temporal sequences. Here, we show that synaptically-driven reaction-diffusion pathways on dendrites can pe...

journal_title：eLife

authors： Bhalla US

更新日期：2017-04-19 00:00:00

abstract：:Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P2-activated, Na+-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the channel activity of TPC1 is strongly dependent on membrane volta...

journal_title：eLife

authors： Zhang X,Chen W,Li P,Calvo R,Southall N,Hu X,Bryant-Genevier M,Feng X,Geng Q,Gao C,Yang M,Tang K,Ferrer M,Marugan JJ,Xu H

更新日期：2019-12-11 00:00:00

abstract：:Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently completed dense connectome,...

journal_title：eLife

authors： Li F,Lindsey JW,Marin EC,Otto N,Dreher M,Dempsey G,Stark I,Bates AS,Pleijzier MW,Schlegel P,Nern A,Takemura SY,Eckstein N,Yang T,Francis A,Braun A,Parekh R,Costa M,Scheffer LK,Aso Y,Jefferis GS,Abbott LF,Litwi

更新日期：2020-12-14 00:00:00

abstract：:Adipocyte differentiation is a strictly controlled process regulated by a series of transcriptional activators. Adipogenic signals activate early adipogenic activators and facilitate the transient formation of early enhanceosomes at target genes. These enhancer regions are subsequently inherited by late enhanceosomes....

journal_title：eLife

authors： Watanabe M,Takahashi H,Saeki Y,Ozaki T,Itoh S,Suzuki M,Mizushima W,Tanaka K,Hatakeyama S

更新日期：2015-04-23 00:00:00