Abstract:
:Combining clonal analysis with a computational agent based model, we investigate how tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE) of the teleost medaka (Oryzias latipes) coordinate their growth rates. NR cell division timing is less variable, consistent with an upstream role as growth inducer. RPE cells divide with greater variability, consistent with a downstream role responding to inductive signals. Strikingly, the arrangement of the retinal ciliary marginal zone niche results in a spatially biased random lineage loss, where stem- and progenitor cell domains emerge spontaneously. Further, our data indicate that NR cells orient division axes to regulate organ shape and retinal topology. We highlight an unappreciated mechanism for growth coordination, where one tissue integrates cues to synchronize growth of nearby tissues. This strategy may enable evolution to modulate cell proliferation parameters in one tissue to adapt whole-organ morphogenesis in a complex vertebrate organ.
journal_name
Elifejournal_title
eLifeauthors
Tsingos E,Höckendorf B,Sütterlin T,Kirchmaier S,Grabe N,Centanin L,Wittbrodt Jdoi
10.7554/eLife.42646subject
Has Abstractpub_date
2019-03-26 00:00:00issn
2050-084Xpii
42646journal_volume
8pub_type
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