Abstract:
:Visual perception and imagery rely on similar representations in the visual cortex. During perception, visual activity is characterized by distinct processing stages, but the temporal dynamics underlying imagery remain unclear. Here, we investigated the dynamics of visual imagery in human participants using magnetoencephalography. Firstly, we show that, compared to perception, imagery decoding becomes significant later and representations at the start of imagery already overlap with later time points. This suggests that during imagery, the entire visual representation is activated at once or that there are large differences in the timing of imagery between trials. Secondly, we found consistent overlap between imagery and perceptual processing around 160 ms and from 300 ms after stimulus onset. This indicates that the N170 gets reactivated during imagery and that imagery does not rely on early perceptual representations. Together, these results provide important insights for our understanding of the neural mechanisms of visual imagery.
journal_name
Elifejournal_title
eLifeauthors
Dijkstra N,Mostert P,Lange FP,Bosch S,van Gerven MAdoi
10.7554/eLife.33904subject
Has Abstractpub_date
2018-05-29 00:00:00issn
2050-084Xpii
33904journal_volume
7pub_type
杂志文章相关文献
eLife文献大全abstract::Direct reprogramming of fibroblasts to neurons induces widespread cellular and transcriptional reconfiguration. Here, we characterized global epigenomic changes during the direct reprogramming of mouse fibroblasts to neurons using whole-genome base-resolution DNA methylation (mC) sequencing. We found that the pioneer ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40197
更新日期:2019-01-15 00:00:00
abstract::Animals seek out relevant information by moving through a dynamic world, but sensory systems are usually studied under highly constrained and passive conditions that may not probe important dimensions of the neural code. Here, we explored neural coding in the barrel cortex of head-fixed mice that tracked walls with th...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12559
更新日期:2015-12-23 00:00:00
abstract::Previous studies had shown that the integration of genome wide expression profiles, in metabolic tissues, with genetic and phenotypic variance, provided valuable insight into the underlying molecular mechanisms. We used RNA-Seq to characterize hypothalamic transcriptome in 99 inbred strains of mice from the Hybrid Mou...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.15614
更新日期:2016-09-13 00:00:00
abstract::The dynamic tyrosination-detyrosination cycle of α-tubulin regulates microtubule functions. Perturbation of this cycle impairs mitosis, neural physiology, and cardiomyocyte contraction. The carboxypeptidases vasohibins 1 and 2 (VASH1 and VASH2), in complex with the small vasohibin-binding protein (SVBP), mediate α-tub...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58157
更新日期:2020-08-10 00:00:00
abstract::Ten countries have reported pfhrp2/pfhrp3 gene deletions since the first observation of pfhrp2-deleted parasites in 2012. In a previous study (Watson et al., 2017), we characterised the drivers selecting for pfhrp2/3 deletions and mapped the regions in Africa with the greatest selection pressure. In February 2018, the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40339
更新日期:2019-05-02 00:00:00
abstract::Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases attenuate β-adrenergic signaling in white adipose tissue. Treatment of 3T3-L1 adipocytes with specific inhibitors of the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01119
更新日期:2013-12-24 00:00:00
abstract::The brain has an impressive ability to withstand neural damage. Diseases that kill neurons can go unnoticed for years, and incomplete brain lesions or silencing of neurons often fail to produce any behavioral effect. How does the brain compensate for such damage, and what are the limits of this compensation? We propos...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12454
更新日期:2016-12-09 00:00:00
abstract::Stem cells are maintained in a specialized microenvironment called niche but the nature of stem cell niche remains poorly defined in many systems. Here we demonstrate that intestinal epithelium-derived BMP serves as a niche signal for intestinal stem cell (ISC) self-renewal in Drosophila adult midgut. We find that BMP...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01857
更新日期:2014-03-11 00:00:00
abstract::Proteins can self-organize into spatial patterns via non-linear dynamic interactions on cellular membranes. Modelling and simulations have shown that small GTPases can generate patterns by coupling guanine nucleotide exchange factors (GEF) to effectors, generating a positive feedback of GTPase activation and membrane ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54434
更新日期:2020-06-08 00:00:00
abstract::Across species, sleep in young animals is critical for normal brain maturation. The molecular determinants of early life sleep remain unknown. Through an RNAi-based screen, we identified a gene, pdm3, required for sleep maturation in Drosophila. Pdm3, a transcription factor, coordinates an early developmental program ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52676
更新日期:2020-03-23 00:00:00
abstract::We present the development and in vivo application of a feedback-based tracking microscope to follow individual mitochondria in sensory neurons of zebrafish larvae with nanometer precision and millisecond temporal resolution. By combining various technical improvements, we tracked individual mitochondria with unpreced...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46059
更新日期:2019-06-10 00:00:00
abstract::To efficiently navigate through the environment and avoid potential threats, an animal must quickly detect the motion of approaching objects. Current models of primate vision place the origins of this complex computation in the visual cortex. Here, we report that detection of approaching motion begins in the retina. S...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51144
更新日期:2020-02-24 00:00:00
abstract::Responses of sensory neurons represent stimulus information, but are also influenced by internal state. For example, when monkeys direct their attention to a visual stimulus, the response gain of specific subsets of neurons in visual cortex changes. Here, we develop a functional model of population activity to investi...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.08998
更新日期:2015-11-02 00:00:00
abstract::Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes. Accordingly, T cells exhibited low basal glycolytic flux and limite...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30938
更新日期:2018-06-18 00:00:00
abstract::D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood. By virally expressing the isoforms in dopamine neurons of D2 receptor knockout mice, th...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09358
更新日期:2015-08-26 00:00:00
abstract::Mycobacterium tuberculosis (Mtb) expresses a broad-spectrum β-lactamase (BlaC) that mediates resistance to one of the highly effective antibacterials, β-lactams. Nonetheless, β-lactams showed mycobactericidal activity in combination with β-lactamase inhibitor, clavulanate (Clav). However, the mechanistic aspects of ho...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.25624
更新日期:2017-05-26 00:00:00
abstract::Conventional Ly6Chi monocytes have developmental plasticity for a spectrum of differentiated phagocytes. Here we show, using conditional deletion strategies in a mouse model of Toll-like receptor (TLR) 7-induced inflammation, that the spectrum of developmental cell fates of Ly6Chi monocytes, and the resultant inflamma...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57007
更新日期:2020-07-29 00:00:00
abstract::Appropriate generalization of learned responses to new situations is vital for adaptive behavior. We provide a circuit-level account of generalization in the electrosensory lobe (ELL) of weakly electric mormyrid fish. Much is already known in this system about a form of learning in which motor corollary discharge sign...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44032
更新日期:2019-03-14 00:00:00
abstract::bicoid mRNA localises to the Drosophila oocyte anterior from stage 9 of oogenesis onwards to provide a local source for Bicoid protein for embryonic patterning. Live imaging at stage 9 reveals that bicoid mRNA particles undergo rapid Dynein-dependent movements near the oocyte anterior, but with no directional bias. Fu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.17537
更新日期:2016-10-28 00:00:00
abstract::Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we use a 'multi-omics' approach to demonstrate that the duration of polymerase pausing generally limits the productive frequency of transcription i...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.29736
更新日期:2017-10-10 00:00:00
abstract::Previously we identified Lam/GramD1 proteins, a family of endoplasmic reticulum membrane proteins with sterol-binding StARkin domains that are implicated in intracellular sterol homeostasis. Here, we show how these proteins exchange sterol molecules with membranes. An aperture at one end of the StARkin domain enables ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53444
更新日期:2019-12-04 00:00:00
abstract::Rodents are emerging as increasingly popular models of visual functions. Yet, evidence that rodent visual cortex is capable of advanced visual processing, such as object recognition, is limited. Here we investigate how neurons located along the progression of extrastriate areas that, in the rat brain, run laterally to...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22794
更新日期:2017-04-11 00:00:00
abstract::Despite their importance in sexual differentiation and reproduction, Y chromosome genes are rarely described because they reside in repeat-rich regions that are difficult to study. Here, we show that Guy1, a unique Y chromosome gene of a major urban malaria mosquito Anopheles stephensi, confers 100% female lethality w...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.19281
更新日期:2016-09-20 00:00:00
abstract::The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury. Here, we report novel pathways in axon regeneration, identified by extending our previous function-based screen using the C. elegans...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39756
更新日期:2018-11-21 00:00:00
abstract::Establishing how neurocircuit activation causes particular behaviors requires modulating the activity of specific neurons. Here, we demonstrate that magnetothermal genetic stimulation provides tetherless deep brain activation sufficient to evoke motor behavior in awake mice. The approach uses alternating magnetic fiel...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27069
更新日期:2017-08-15 00:00:00
abstract::The design of synthetic optogenetic tools that allow precise spatiotemporal control of biological processes previously inaccessible to optogenetic control has developed rapidly over the last years. Rational design of such tools requires detailed knowledge of allosteric light signaling in natural photoreceptors. To und...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11860
更新日期:2016-01-12 00:00:00
abstract::INAD assembles key enzymes of the Drosophila compound eye photo-transduction pathway into a supramolecular complex, supporting efficient and fast light signaling. However, the molecular mechanism that governs the interaction between INAD and NORPA (phospholipase Cβ, PLCβ), a key step for the fast kinetics of the light...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.41848
更新日期:2018-12-10 00:00:00
abstract::In recent years, functional genomics approaches combining genetic information with bulk RNA-sequencing data have identified the downstream expression effects of disease-associated genetic risk factors through so-called expression quantitative trait locus (eQTL) analysis. Single-cell RNA-sequencing creates enormous opp...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.52155
更新日期:2020-03-09 00:00:00
abstract::Sparse, sequential patterns of neural activity have been observed in numerous brain areas during timekeeping and motor sequence tasks. Inspired by such observations, we construct a model of the striatum, an all-inhibitory circuit where sequential activity patterns are prominent, addressing the following key challenges...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.26084
更新日期:2017-05-08 00:00:00
abstract::The equilibrium between proliferation and quiescence of myogenic progenitor and stem cells is tightly regulated to ensure appropriate skeletal muscle growth and repair. The non-receptor tyrosine phosphatase Ptpn11 (Shp2) is an important transducer of growth factor and cytokine signals. Here we combined complex genetic...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21552
更新日期:2017-05-02 00:00:00