The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion.

abstract：:Across species, sleep in young animals is critical for normal brain maturation. The molecular determinants of early life sleep remain unknown. Through an RNAi-based screen, we identified a gene, pdm3, required for sleep maturation in Drosophila. Pdm3, a transcription factor, coordinates an early developmental program ...

journal_title：eLife

authors： Chakravarti Dilley L,Szuperak M,Gong NN,Williams CE,Saldana RL,Garbe DS,Syed MH,Jain R,Kayser MS

更新日期：2020-03-23 00:00:00

abstract：:Two recently discovered transcription factors stop cells from dividing when plants face extreme heat and DNA damage. ...

journal_title：eLife

authors： Eekhout T,De Veylder L

更新日期：2019-04-09 00:00:00

abstract：:Pregnancy complications are poorly represented in the archeological record, despite their importance in contemporary and ancient societies. While excavating a Byzantine cemetery in Troy, we discovered calcified abscesses among a woman's remains. Scanning electron microscopy of the tissue revealed 'ghost cells', result...

journal_title：eLife

authors： Devault AM,Mortimer TD,Kitchen A,Kiesewetter H,Enk JM,Golding GB,Southon J,Kuch M,Duggan AT,Aylward W,Gardner SN,Allen JE,King AM,Wright G,Kuroda M,Kato K,Briggs DE,Fornaciari G,Holmes EC,Poinar HN,Pepperell CS

更新日期：2017-01-10 00:00:00

abstract：:The straight-tusked elephants Palaeoloxodon spp. were widespread across Eurasia during the Pleistocene. Phylogenetic reconstructions using morphological traits have grouped them with Asian elephants (Elephas maximus), and many paleontologists place Palaeoloxodon within Elephas. Here, we report the recovery of full mit...

journal_title：eLife

authors： Meyer M,Palkopoulou E,Baleka S,Stiller M,Penkman KEH,Alt KW,Ishida Y,Mania D,Mallick S,Meijer T,Meller H,Nagel S,Nickel B,Ostritz S,Rohland N,Schauer K,Schüler T,Roca AL,Reich D,Shapiro B,Hofreiter M

更新日期：2017-06-06 00:00:00

abstract：:Despite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior-posterior axis. Hox proteins exert their function by interaction wit...

journal_title：eLife

authors： Hudry B,Thomas-Chollier M,Volovik Y,Duffraisse M,Dard A,Frank D,Technau U,Merabet S

更新日期：2014-03-18 00:00:00

abstract：:We determined differential gene expression in response to high glucose in lymphoblastoid cell lines derived from matched individuals with type 1 diabetes with and without retinopathy. Those genes exhibiting the largest difference in glucose response were assessed for association with diabetic retinopathy in a genome-w...

journal_title：eLife

authors： Skol AD,Jung SC,Sokovic AM,Chen S,Fazal S,Sosina O,Borkar PP,Lin A,Sverdlov M,Cao D,Swaroop A,Bebu I,DCCT\/EDIC Study group.,Stranger BE,Grassi MA

更新日期：2020-11-09 00:00:00

abstract：:Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia affecting geographically distant populations of two species of mussels (Mytilus chilensis in South America and M. edulis in Eur...

journal_title：eLife

authors： Yonemitsu MA,Giersch RM,Polo-Prieto M,Hammel M,Simon A,Cremonte F,Avilés FT,Merino-Véliz N,Burioli EA,Muttray AF,Sherry J,Reinisch C,Baldwin SA,Goff SP,Houssin M,Arriagada G,Vázquez N,Bierne N,Metzger MJ

更新日期：2019-11-05 00:00:00

abstract：:Journals and other scientific organizations produce a diverse variety of plain-language summaries. ...

journal_title：eLife

authors： Shailes S

更新日期：2017-03-15 00:00:00

abstract：:Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens. RNA viruses typically have high mutation rates, resulting in frequent production of protein variants with compromised biophysical properties. Their evolution i...

journal_title：eLife

authors： Phillips AM,Gonzalez LO,Nekongo EE,Ponomarenko AI,McHugh SM,Butty VL,Levine SS,Lin YS,Mirny LA,Shoulders MD

更新日期：2017-09-26 00:00:00

abstract：:The gut microbiota of patients recently diagnosed with rheumatoid arthritis is enriched in microbes belonging to the Prevotella genus. ...

journal_title：eLife

authors： Mathis D

更新日期：2013-11-05 00:00:00

abstract：:Humans employ different strategies when making decisions. Previous research has reported reduced reliance on model-based strategies with aging, but it remains unclear whether this is due to cognitive or motivational factors. Moreover, it is not clear how aging affects the metacontrol of decision making, that is the dy...

journal_title：eLife

authors： Bolenz F,Kool W,Reiter AM,Eppinger B

更新日期：2019-08-09 00:00:00

abstract：:Pathological metabolic conditions such as ischemia induce the rupture of the mitochondrial envelope and the release of pro-apoptotic proteins, leading to cell death. At the onset of this process, the inner mitochondrial membrane becomes depolarized and permeable to osmolytes, proposedly due to the opening of a non-sel...

journal_title：eLife

authors： Zhou W,Marinelli F,Nief C,Faraldo-Gómez JD

更新日期：2017-02-10 00:00:00

abstract：:The non-canonical Wnt/Ca2+ signaling pathway plays important roles in embryonic development, tissue formation and diseases. However, it is unclear how the Wnt ligand-stimulated, G protein-coupled receptor Frizzled activates phospholipases for calcium release. Here, we report that the zebrafish/human phosphatidylinosit...

journal_title：eLife

authors： Gong B,Shen W,Xiao W,Meng Y,Meng A,Jia S

更新日期：2017-05-02 00:00:00

abstract：:Two distinct mechanisms for primordial germ cell (PGC) specification are observed within Bilatera: early determination by maternal factors or late induction by zygotic cues. Here we investigate the molecular basis for PGC specification in Nematostella, a representative pre-bilaterian animal where PGCs arise as paired ...

journal_title：eLife

authors： Chen CY,McKinney SA,Ellington LR,Gibson MC

更新日期：2020-09-24 00:00:00

abstract：:While traditional microbiological freshwater tests focus on the detection of specific bacterial indicator species, including pathogens, direct tracing of all aquatic DNA through metagenomics poses a profound alternative. Yet, in situ metagenomic water surveys face substantial challenges in cost and logistics. Here, we...

journal_title：eLife

authors： Urban L,Holzer A,Baronas JJ,Hall MB,Braeuninger-Weimer P,Scherm MJ,Kunz DJ,Perera SN,Martin-Herranz DE,Tipper ET,Salter SJ,Stammnitz MR

更新日期：2021-01-19 00:00:00

abstract：:Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR) pathways. Like mice lacking primary UPR components, hepatic Lrh-1-null m...

journal_title：eLife

authors： Mamrosh JL,Lee JM,Wagner M,Stambrook PJ,Whitby RJ,Sifers RN,Wu SP,Tsai MJ,Demayo FJ,Moore DD

更新日期：2014-04-15 00:00:00

abstract：:Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of these symptoms, yet cellular sources of neuroinflammation during malignancy are unknown. In a mouse model of pancreatic ductal adenocarcinoma (PDAC), we observed ea...

journal_title：eLife

authors： Burfeind KG,Zhu X,Norgard MA,Levasseur PR,Huisman C,Buenafe AC,Olson B,Michaelis KA,Torres ER,Jeng S,McWeeney S,Raber J,Marks DL

更新日期：2020-05-11 00:00:00

abstract：:The Hippo-YAP pathway is a central regulator of cell contact inhibition, proliferation and death. There are conflicting reports regarding the role of Angiomotin (Amot) in regulating this pathway. While some studies suggest a YAP-inhibitory function other studies indicate Amot is required for YAP activity. Here, we des...

journal_title：eLife

authors： Moleirinho S,Hoxha S,Mandati V,Curtale G,Troutman S,Ehmer U,Kissil JL

更新日期：2017-05-03 00:00:00

abstract：:The phylogenetic placement of the morphologically simple placozoans is crucial to understanding the evolution of complex animal traits. Here, we examine the influence of adding new genomes from placozoans to a large dataset designed to study the deepest splits in the animal phylogeny. Using site-heterogeneous substitu...

journal_title：eLife

authors： Laumer CE,Gruber-Vodicka H,Hadfield MG,Pearse VB,Riesgo A,Marioni JC,Giribet G

更新日期：2018-10-30 00:00:00

abstract：:During development, tissue repair, and tumor growth, most blood vessel networks are generated through angiogenesis. Vascular endothelial growth factor (VEGF) is a key regulator of this process and currently both VEGF and its receptors, VEGFR1, VEGFR2, and Neuropilin1 (NRP1), are targeted in therapeutic strategies for ...

journal_title：eLife

authors： Gelfand MV,Hagan N,Tata A,Oh WJ,Lacoste B,Kang KT,Kopycinska J,Bischoff J,Wang JH,Gu C

更新日期：2014-09-22 00:00:00

abstract：:Newly born cells either continue to proliferate or exit the cell division cycle. This decision involves delaying expression of Cyclin E that promotes DNA replication. ORC1, the Origin Recognition Complex (ORC) large subunit, is inherited into newly born cells after it binds to condensing chromosomes during the precedi...

journal_title：eLife

authors： Hossain M,Stillman B

更新日期：2016-07-26 00:00:00

abstract：:Lissencephaly ('smooth brain') is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease - lissencephaly-1 (LIS1) - has been a focus of intense scrutiny since its first identification almost 30 years ago. LIS1 is a criti...

journal_title：eLife

authors： Markus SM,Marzo MG,McKenney RJ

更新日期：2020-07-21 00:00:00

abstract：:The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome-wide association studies on 78 facial shape phenotypes quantified from 3-dimensional facial images of 10,115 Europeans identif...

journal_title：eLife

authors： Xiong Z,Dankova G,Howe LJ,Lee MK,Hysi PG,de Jong MA,Zhu G,Adhikari K,Li D,Li Y,Pan B,Feingold E,Marazita ML,Shaffer JR,McAloney K,Xu SH,Jin L,Wang S,de Vrij FM,Lendemeijer B,Richmond S,Zhurov A,Lewis S,Sharp

更新日期：2019-11-26 00:00:00

abstract：:Recent advances in single-cell transcriptomics techniques have opened the door to the study of gene regulatory networks (GRNs) at the single-cell level. Here, we studied the GRNs controlling the emergence of hematopoietic stem and progenitor cells from mouse embryonic endothelium using a combination of single-cell tra...

journal_title：eLife

authors： Bergiers I,Andrews T,Vargel Bölükbaşı Ö,Buness A,Janosz E,Lopez-Anguita N,Ganter K,Kosim K,Celen C,Itır Perçin G,Collier P,Baying B,Benes V,Hemberg M,Lancrin C

更新日期：2018-03-20 00:00:00

abstract：:The receptor protein Dectin-1 recognizes structures found on cancerous cells, and then triggers an anti-tumor immune response. ...

journal_title：eLife

authors： Okabe Y,Medzhitov R

更新日期：2014-09-24 00:00:00

abstract：:Imaging sperm as they travel through the female reproductive tract has revealed new details about fertilization at the molecular level. ...

journal_title：eLife

authors： Komondor KM,Carlson AE

更新日期：2020-12-02 00:00:00

abstract：:Negative regulators of adult neurogenesis are of particular interest as targets to enhance neuronal repair, but few have yet been identified. Planarians can regenerate their entire CNS using pluripotent adult stem cells, and this process is robustly regulated to ensure that new neurons are produced in proper abundance...

journal_title：eLife

authors： Karge A,Bonar NA,Wood S,Petersen CP

更新日期：2020-01-20 00:00:00

abstract：:Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-ra...

journal_title：eLife

authors： Fernandez LM,Vantomme G,Osorio-Forero A,Cardis R,Béard E,Lüthi A

更新日期：2018-12-25 00:00:00

abstract：:Establishing how neurocircuit activation causes particular behaviors requires modulating the activity of specific neurons. Here, we demonstrate that magnetothermal genetic stimulation provides tetherless deep brain activation sufficient to evoke motor behavior in awake mice. The approach uses alternating magnetic fiel...

journal_title：eLife

authors： Munshi R,Qadri SM,Zhang Q,Castellanos Rubio I,Del Pino P,Pralle A

更新日期：2017-08-15 00:00:00

abstract：: ...

journal_title：eLife

authors： DeAngelis BD,Zavatone-Veth JA,Clark DA

更新日期：2020-12-04 00:00:00