Correction: The manifold structure of limb coordination in walking Drosophila.

abstract：:Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of precursor cells from mouse forebrain at embryonic days E8.5 vs. E10.5 (before vs. after neural tube closure). Genes encoding protein ...

journal_title：eLife

authors： Chau KF,Shannon ML,Fame RM,Fonseca E,Mullan H,Johnson MB,Sendamarai AK,Springel MW,Laurent B,Lehtinen MK

更新日期：2018-05-10 00:00:00

abstract：:Hepatitis B virus (HBV) is an important but difficult to study human pathogen. Most basics of the hepadnaviral life-cycle were unraveled using duck HBV (DHBV) as a model although DHBV has a capsid protein (CP) comprising ~260 rather than ~180 amino acids. Here we present high-resolution structures of several DHBV caps...

journal_title：eLife

authors： Makbul C,Nassal M,Böttcher B

更新日期：2020-08-14 00:00:00

abstract：:Responses of sensory neurons represent stimulus information, but are also influenced by internal state. For example, when monkeys direct their attention to a visual stimulus, the response gain of specific subsets of neurons in visual cortex changes. Here, we develop a functional model of population activity to investi...

journal_title：eLife

authors： Rabinowitz NC,Goris RL,Cohen M,Simoncelli EP

更新日期：2015-11-02 00:00:00

abstract：:Spatial and temporal cues are required to specify neuronal diversity, but how these cues are integrated in neural progenitors remains unknown. Drosophila progenitors (neuroblasts) are a good model: they are individually identifiable with relevant spatial and temporal transcription factors known. Here we test whether s...

journal_title：eLife

authors： Sen SQ,Chanchani S,Southall TD,Doe CQ

更新日期：2019-01-29 00:00:00

abstract：:Larval recruitment, the transition of pelagic larvae into reef-associated juveniles, is a critical step for the resilience of marine fish populations but its molecular control is unknown. Here, we investigate whether thyroid-hormones (TH) and their receptors (TR) coordinate the larval recruitment of the coral-reef-fis...

journal_title：eLife

authors： Holzer G,Besson M,Lambert A,François L,Barth P,Gillet B,Hughes S,Piganeau G,Leulier F,Viriot L,Lecchini D,Laudet V

更新日期：2017-10-30 00:00:00

abstract：:SUMO1-conjugation of proteins at neuronal synapses is considered to be a major post-translational regulatory process in nerve cell and synapse function, but the published evidence for SUMO1-conjugation at synapses is contradictory. We employed multiple genetic mouse models for stringently controlled biochemical and im...

journal_title：eLife

authors： Daniel JA,Cooper BH,Palvimo JJ,Zhang FP,Brose N,Tirard M

更新日期：2017-06-09 00:00:00

abstract：:The mammalian auditory sensory epithelium has one of the most stereotyped cellular patterns known in vertebrates. Mechano-sensory hair cells are arranged in precise rows, with one row of inner and three rows of outer hair cells spanning the length of the spiral-shaped sensory epithelium. Aiding such precise cellular p...

journal_title：eLife

authors： Prajapati-DiNubila M,Benito-Gonzalez A,Golden EJ,Zhang S,Doetzlhofer A

更新日期：2019-06-12 00:00:00

abstract：:Obesity produces a chronic inflammatory state involving the NFκB pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In this study, we report that these kinases attenuate β-adrenergic signaling in white adipose tissue. Treatment of 3T3-L1 adipocytes with specific inhibitors of the...

journal_title：eLife

authors： Mowers J,Uhm M,Reilly SM,Simon J,Leto D,Chiang SH,Chang L,Saltiel AR

更新日期：2013-12-24 00:00:00

abstract：:The anterior cingulate cortex (ACC) encodes information supporting mnemonic and cognitive processes. We show here that a rat's position can be decoded with high spatiotemporal resolution from ACC activity. ACC neurons encoded the current state of the animal and task, except for brief excursions that sometimes occurred...

journal_title：eLife

authors： Mashhoori A,Hashemnia S,McNaughton BL,Euston DR,Gruber AJ

更新日期：2018-04-17 00:00:00

abstract：:Goal-directed behavior involves distributed neuronal circuits in the mammalian brain, including diverse regions of neocortex. However, the cellular basis of long-range cortico-cortical signaling during goal-directed behavior is poorly understood. Here, we recorded membrane potential of excitatory layer 2/3 pyramidal n...

journal_title：eLife

authors： Yamashita T,Petersen CCh

更新日期：2016-06-21 00:00:00

abstract：:Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of either arm. What is the nature and role of activity across the two hemispheres? We recorded muscles and neurons bilaterally while monkeys cycled with each arm. Most neurons were active during movement of either arm. Responses were...

journal_title：eLife

authors： Ames KC,Churchland MM

更新日期：2019-10-09 00:00:00

abstract：:Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelle...

journal_title：eLife

authors： Banerjee JJ,Aerne BL,Holder MV,Hauri S,Gstaiger M,Tapon N

更新日期：2017-06-30 00:00:00

abstract：:Axons span extreme distances and are subject to significant stretch deformations during limb movements or sudden head movements, especially during impacts. Yet, axon biomechanics, and its relation to the ultrastructure that allows axons to withstand mechanical stress, is poorly understood. Using a custom developed for...

journal_title：eLife

authors： Dubey S,Bhembre N,Bodas S,Veer S,Ghose A,Callan-Jones A,Pullarkat P

更新日期：2020-04-08 00:00:00

abstract：:The collapse of iconic, keystone populations of sockeye (Oncorhynchus nerka) and Chinook (Oncorhynchus tshawytscha) salmon in the Northeast Pacific is of great concern. It is thought that infectious disease may contribute to declines, but little is known about viruses endemic to Pacific salmon. Metatranscriptomic sequ...

journal_title：eLife

authors： Mordecai GJ,Miller KM,Di Cicco E,Schulze AD,Kaukinen KH,Ming TJ,Li S,Tabata A,Teffer A,Patterson DA,Ferguson HW,Suttle CA

更新日期：2019-09-03 00:00:00

abstract：:A major challenge in neuroscience is to longitudinally monitor whole brain activity across multiple spatial scales in the same animal. Functional UltraSound (fUS) is an emerging technology that offers images of cerebral blood volume over large brain portions. Here we show for the first time its capability to resolve t...

journal_title：eLife

authors： Bimbard C,Demene C,Girard C,Radtke-Schuller S,Shamma S,Tanter M,Boubenec Y

更新日期：2018-06-28 00:00:00

abstract：:Optical imaging has become a powerful tool for studying brains in vivo. The opacity of adult brains makes microendoscopy, with an optical probe such as a gradient index (GRIN) lens embedded into brain tissue to provide optical relay, the method of choice for imaging neurons and neural activity in deeply buried brain s...

journal_title：eLife

authors： Meng G,Liang Y,Sarsfield S,Jiang WC,Lu R,Dudman JT,Aponte Y,Ji N

更新日期：2019-01-04 00:00:00

abstract：:Beige/brite adipocytes are induced within white adipose tissues (WAT) and, when activated, consume glucose and fatty acids to produce heat. Classically, two stimuli have been used to trigger a beiging response: cold temperatures and β3-adrenergic receptor (Adrb3) agonists. These two beiging triggers have been used int...

journal_title：eLife

authors： Jiang Y,Berry DC,Graff JM

更新日期：2017-10-11 00:00:00

abstract：:Most cellular features have a range of states, but understanding the mechanisms responsible for interspecific divergence is a challenge for evolutionary cell biology. Models are developed for the distribution of mean phenotypes likely to evolve under the joint forces of mutation and genetic drift in the face of consta...

journal_title：eLife

authors： Lynch M

更新日期：2018-06-21 00:00:00

abstract：:Macrophages derive from multiple sources of hematopoietic progenitors. Most macrophages require colony-stimulating factor 1 receptor (CSF1R), but some macrophages persist in the absence of CSF1R. Here, we analyzed mpeg1:GFP-expressing macrophages in csf1r-deficient zebrafish and report that embryonic macrophages emerg...

journal_title：eLife

authors： Kuil LE,Oosterhof N,Ferrero G,Mikulášová T,Hason M,Dekker J,Rovira M,van der Linde HC,van Strien PM,de Pater E,Schaaf G,Bindels EM,Wittamer V,van Ham TJ

更新日期：2020-05-05 00:00:00

abstract：:Breast cancer stem cells (BCSCs) contribute to intra-tumoral heterogeneity and therapeutic resistance. However, the binary concept of universal BCSCs co-existing with bulk tumor cells is over-simplified. Through single-cell RNA-sequencing, we found that Neu, PyMT and BRCA1-null mammary tumors each corresponded to a sp...

journal_title：eLife

authors： Yeo SK,Zhu X,Okamoto T,Hao M,Wang C,Lu P,Lu LJ,Guan JL

更新日期：2020-08-25 00:00:00

abstract：:Postmitotic tissues are incapable of replacing damaged cells through proliferation, but need to rely on buffering mechanisms to prevent tissue disintegration. By constitutively activating the Ras/MAPK-pathway via RasV12-overexpression in the postmitotic salivary glands of Drosophila larvae, we overrode the glands adap...

journal_title：eLife

authors： Krautz R,Khalili D,Theopold U

更新日期：2020-12-30 00:00:00

abstract：:During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity by inhibiting synaptogenesis, our knowledge about their intracellular mechanisms remains limited. Here we show that Ra...

journal_title：eLife

authors： Chen X,Shibata AC,Hendi A,Kurashina M,Fortes E,Weilinger NL,MacVicar BA,Murakoshi H,Mizumoto K

更新日期：2018-07-31 00:00:00

abstract：:Grid cells in the brain respond when an animal occupies a periodic lattice of 'grid fields' during navigation. Grids are organized in modules with different periodicity. We propose that the grid system implements a hierarchical code for space that economizes the number of neurons required to encode location with a giv...

journal_title：eLife

authors： Wei XX,Prentice J,Balasubramanian V

更新日期：2015-09-03 00:00:00

abstract：:The cellular architecture of the ventral tegmental area (VTA), the main hub of the brain reward system, remains only partially characterized. To extend the characterization to inhibitory neurons, we have identified three distinct subtypes of somatostatin (Sst)-expressing neurons in the mouse VTA. These neurons differ ...

journal_title：eLife

authors： Nagaeva E,Zubarev I,Bengtsson Gonzales C,Forss M,Nikouei K,de Miguel E,Elsilä L,Linden AM,Hjerling-Leffler J,Augustine GJ,Korpi ER

更新日期：2020-08-04 00:00:00

abstract：:Dendrites shape information flow in neurons. Yet, there is little consensus on the level of spatial complexity at which they operate. Through carefully chosen parameter fits, solvable in the least-squares sense, we obtain accurate reduced compartmental models at any level of complexity. We show that (back-propagating)...

journal_title：eLife

authors： Wybo WA,Jordan J,Ellenberger B,Marti Mengual U,Nevian T,Senn W

更新日期：2021-01-26 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Although rigorous efforts identified the presence of 'cancer stem cells (CSCs)' in PDAC and molecular markers for them, stem cell dynamics in vivo have not been clearly demonstrated. Here we focused on Doublecortin-like kinase 1 (Dclk1), known as a CSC ...

journal_title：eLife

authors： Maruno T,Fukuda A,Goto N,Tsuda M,Ikuta K,Hiramatsu Y,Ogawa S,Nakanishi Y,Yamaga Y,Yoshioka T,Takaori K,Uemoto S,Saur D,Chiba T,Seno H

更新日期：2021-01-04 00:00:00

abstract：:The ubiquitous presence of inhibitory interneurons in the thalamus of primates contrasts with the sparsity of interneurons reported in mice. Here, we identify a larger than expected complexity and distribution of interneurons across the mouse thalamus, where all thalamic interneurons can be traced back to two developm...

journal_title：eLife

authors： Jager P,Moore G,Calpin P,Durmishi X,Salgarella I,Menage L,Kita Y,Wang Y,Kim DW,Blackshaw S,Schultz SR,Brickley S,Shimogori T,Delogu A

更新日期：2021-02-01 00:00:00

abstract：:Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR-mediated chloride and bicarbonate transport, with dysregulation of epithelial sodium channels (ENaC). These changes alter fluid and electrolyte homeostasis...

journal_title：eLife

authors： Scambler T,Jarosz-Griffiths HH,Lara-Reyna S,Pathak S,Wong C,Holbrook J,Martinon F,Savic S,Peckham D,McDermott MF

更新日期：2019-09-18 00:00:00

abstract：:KdpFABC is an ATP-dependent K+ pump that ensures bacterial survival in K+-deficient environments. Whereas transcriptional activation of kdpFABC expression is well studied, a mechanism for down-regulation when K+ levels are restored has not been described. Here, we show that KdpFABC is inhibited when cells return to a ...

journal_title：eLife

authors： Sweet ME,Zhang X,Erdjument-Bromage H,Dubey V,Khandelia H,Neubert TA,Pedersen BP,Stokes DL

更新日期：2020-09-21 00:00:00

abstract：:The controversy surrounding 'gain-of-function' experiments on high-consequence avian influenza viruses has highlighted the role of ferret transmission experiments in studying the transmission potential of novel influenza strains. However, the mapping between influenza transmission in ferrets and in humans is unsubstan...

journal_title：eLife

authors： Buhnerkempe MG,Gostic K,Park M,Ahsan P,Belser JA,Lloyd-Smith JO

更新日期：2015-09-02 00:00:00