Multi-scale mapping along the auditory hierarchy using high-resolution functional UltraSound in the awake ferret.

abstract：:The neural control of transition between posture and movement encompasses the regulation of reflex-stabilizing mechanisms to enable motion. Optimal feedback theory suggests that such transitions require the disengagement of one motor control policy before the implementation of another. To test this possibility, we inv...

journal_title：eLife

authors： Tisserand R,Dakin CJ,Van der Loos MH,Croft EA,Inglis TJ,Blouin JS

更新日期：2018-07-10 00:00:00

abstract：:Neoangiogenesis is a pivotal therapeutic target in glioblastoma. Tumor monitoring requires imaging methods to assess treatment effects and disease progression. Until now mapping of the tumor vasculature has been difficult. We have developed a combined magnetic resonance and optical toolkit to study neoangiogenesis in ...

journal_title：eLife

authors： Breckwoldt MO,Bode J,Kurz FT,Hoffmann A,Ochs K,Ott M,Deumelandt K,Krüwel T,Schwarz D,Fischer M,Helluy X,Milford D,Kirschbaum K,Solecki G,Chiblak S,Abdollahi A,Winkler F,Wick W,Platten M,Heiland S,Bendszus M,Tews

更新日期：2016-02-02 00:00:00

abstract：:Coat protein complex II (COPII) mediates formation of the membrane vesicles that export newly synthesised proteins from the endoplasmic reticulum. The inner COPII proteins bind to cargo and membrane, linking them to the outer COPII components that form a cage around the vesicle. Regulated flexibility in coat architect...

journal_title：eLife

authors： Zanetti G,Prinz S,Daum S,Meister A,Schekman R,Bacia K,Briggs JA

更新日期：2013-09-17 00:00:00

abstract：:Recent work draws attention to community-community encounters ('coalescence') as likely an important factor shaping natural ecosystems. This work builds on MacArthur's classic model of competitive coexistence to investigate such community-level competition in a minimal theoretical setting. It is shown that the ability...

journal_title：eLife

authors： Tikhonov M

更新日期：2016-06-16 00:00:00

abstract：:Embryonic polarity of invertebrates, amphibians and fish is specified largely by maternal determinants, which fixes cell fates early in development. In contrast, amniote embryos remain plastic and can form multiple individuals until gastrulation. How is their polarity determined? In the chick embryo, the earliest know...

journal_title：eLife

authors： Torlopp A,Khan MA,Oliveira NM,Lekk I,Soto-Jiménez LM,Sosinsky A,Stern CD

更新日期：2014-12-11 00:00:00

abstract：:Signaling molecules activate distinct patterns of gene expression to coordinate embryogenesis, but how spatiotemporal expression diversity is generated is an open question. In zebrafish, a BMP signaling gradient patterns the dorsal-ventral axis. We systematically identified target genes responding to BMP and found tha...

journal_title：eLife

authors： Rogers KW,ElGamacy M,Jordan BM,Müller P

更新日期：2020-11-11 00:00:00

abstract：:V-ATPase is an energy converting enzyme, coupling ATP hydrolysis/synthesis in the hydrophilic V1 domain, with proton flow through the Vo membrane domain, via rotation of the central rotor complex relative to the surrounding stator apparatus. Upon dissociation from the V1 domain, the Vo domain of the eukaryotic V-ATPas...

journal_title：eLife

authors： Kishikawa JI,Nakanishi A,Furuta A,Kato T,Namba K,Tamakoshi M,Mitsuoka K,Yokoyama K

更新日期：2020-07-08 00:00:00

abstract：:Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness the endogenous process of intracellular lipid-sorting to enable mucosal absorption of the incret...

journal_title：eLife

authors： Garcia-Castillo MD,Chinnapen DJ,Te Welscher YM,Gonzalez RJ,Softic S,Pacheco M,Mrsny RJ,Kahn CR,von Andrian UH,Lau J,Pentelute BL,Lencer WI

更新日期：2018-05-31 00:00:00

abstract：:Bioluminescence is a powerful biological signal that scientists have repurposed as a reporter for gene expression in plants and animals. However, there are downsides associated with the need to provide a substrate to these reporters, including its high cost and non-uniform tissue penetration. In this work we reconstit...

journal_title：eLife

authors： Khakhar A,Starker CG,Chamness JC,Lee N,Stokke S,Wang C,Swanson R,Rizvi F,Imaizumi T,Voytas DF

更新日期：2020-03-25 00:00:00

abstract：:The orbitofrontal cortex (OFC) is critical for updating reward-directed behaviours flexibly when outcomes are devalued or when task contingencies are reversed. Failure to update behaviour in outcome devaluation and reversal learning procedures are considered canonical deficits following OFC lesions in non-human primat...

journal_title：eLife

authors： Panayi MC,Killcross S

更新日期：2018-07-25 00:00:00

abstract：:India comprises much of the persisting global childhood measles mortality. India implemented a mass second-dose measles immunization campaign in 2010. We used interrupted time series and multilevel regression to quantify the campaign's impact on measles mortality using the nationally representative Million Death Study...

journal_title：eLife

authors： Wong BK,Fadel SA,Awasthi S,Khera A,Kumar R,Menon G,Jha P

更新日期：2019-03-05 00:00:00

abstract：:Visual perception and imagery rely on similar representations in the visual cortex. During perception, visual activity is characterized by distinct processing stages, but the temporal dynamics underlying imagery remain unclear. Here, we investigated the dynamics of visual imagery in human participants using magnetoenc...

journal_title：eLife

authors： Dijkstra N,Mostert P,Lange FP,Bosch S,van Gerven MA

更新日期：2018-05-29 00:00:00

abstract：:We wish to identify determinants of endothelial lineage. Murine embryonic stem cells (mESC) were fused with human endothelial cells in stable, non-dividing, heterokaryons. Using RNA-seq, it is possible to discriminate between human and mouse transcripts in these chimeric heterokaryons. We observed a temporal pattern o...

journal_title：eLife

authors： Wong WT,Matrone G,Tian X,Tomoiaga SA,Au KF,Meng S,Yamazoe S,Sieveking D,Chen K,Burns DM,Chen JK,Blau HM,Cooke JP

更新日期：2017-03-21 00:00:00

abstract：:Dopamine neurons respond to errors in predicting value-neutral sensory information. These data, combined with causal evidence that dopamine transients support sensory-based associative learning, suggest that the dopamine system signals a multidimensional prediction error. Yet such complexity is not evident in the acti...

journal_title：eLife

authors： Stalnaker TA,Howard JD,Takahashi YK,Gershman SJ,Kahnt T,Schoenbaum G

更新日期：2019-11-01 00:00:00

abstract：:New ages for flowstone, sediments and fossil bones from the Dinaledi Chamber are presented. We combined optically stimulated luminescence dating of sediments with U-Th and palaeomagnetic analyses of flowstones to establish that all sediments containing Homo naledi fossils can be allocated to a single stratigraphic ent...

journal_title：eLife

authors： Dirks PH,Roberts EM,Hilbert-Wolf H,Kramers JD,Hawks J,Dosseto A,Duval M,Elliott M,Evans M,Grün R,Hellstrom J,Herries AI,Joannes-Boyau R,Makhubela TV,Placzek CJ,Robbins J,Spandler C,Wiersma J,Woodhead J,Berger LR

更新日期：2017-05-09 00:00:00

abstract：:β-Propellers arise through the amplification of a supersecondary structure element called a blade. This process produces toroids of between four and twelve repeats, which are almost always arranged sequentially in a single polypeptide chain. We found that new propellers evolve continuously by amplification from single...

journal_title：eLife

authors： Afanasieva E,Chaudhuri I,Martin J,Hertle E,Ursinus A,Alva V,Hartmann MD,Lupas AN

更新日期：2019-10-15 00:00:00

abstract：:Imaging sperm as they travel through the female reproductive tract has revealed new details about fertilization at the molecular level. ...

journal_title：eLife

authors： Komondor KM,Carlson AE

更新日期：2020-12-02 00:00:00

abstract：:Human lung adenocarcinoma exhibits a propensity for de-differentiation, complicating diagnosis and treatment, and predicting poorer patient survival. In genetically engineered mouse models of lung cancer, expression of the BRAFV600E oncoprotein kinase initiates the growth of benign tumors retaining characteristics of ...

journal_title：eLife

authors： van Veen JE,Scherzer M,Boshuizen J,Chu M,Liu A,Landman A,Green S,Trejo C,McMahon M

更新日期：2019-08-27 00:00:00

abstract：:Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is presented, the most relevant memory should be updated. In a contextual version of the object recogniti...

journal_title：eLife

authors： Morici JF,Miranda M,Gallo FT,Zanoni B,Bekinschtein P,Weisstaub NV

更新日期：2018-05-02 00:00:00

abstract：:Tissue elongation and its control by spatiotemporal signals is a major developmental question. Currently, it is thought that Drosophila ovarian follicular epithelium elongation requires the planar polarization of the basal domain cytoskeleton and of the extra-cellular matrix, associated with a dynamic process of rotat...

journal_title：eLife

authors： Alégot H,Pouchin P,Bardot O,Mirouse V

更新日期：2018-02-08 00:00:00

abstract：:Peroxiredoxins are H2O2 scavenging enzymes that also carry out H2O2 signaling and chaperone functions. In yeast, the major cytosolic peroxiredoxin, Tsa1 is required for both promoting resistance to H2O2 and extending lifespan upon caloric restriction. We show here that Tsa1 effects both these functions not by scavengi...

journal_title：eLife

authors： Roger F,Picazo C,Reiter W,Libiad M,Asami C,Hanzén S,Gao C,Lagniel G,Welkenhuysen N,Labarre J,Nyström T,Grøtli M,Hartl M,Toledano MB,Molin M

更新日期：2020-07-14 00:00:00

abstract：:The controversy surrounding 'gain-of-function' experiments on high-consequence avian influenza viruses has highlighted the role of ferret transmission experiments in studying the transmission potential of novel influenza strains. However, the mapping between influenza transmission in ferrets and in humans is unsubstan...

journal_title：eLife

authors： Buhnerkempe MG,Gostic K,Park M,Ahsan P,Belser JA,Lloyd-Smith JO

更新日期：2015-09-02 00:00:00

abstract：:A spring-loaded mechanism can explain the activation process for a protein that has a crucial role in maintaining the genomic integrity of immature eggs cells. ...

journal_title：eLife

authors： Amelio I,Melino G

更新日期：2016-05-23 00:00:00

abstract：:Forebrain precursor cells are dynamic during early brain development, yet the underlying molecular changes remain elusive. We observed major differences in transcriptional signatures of precursor cells from mouse forebrain at embryonic days E8.5 vs. E10.5 (before vs. after neural tube closure). Genes encoding protein ...

journal_title：eLife

authors： Chau KF,Shannon ML,Fame RM,Fonseca E,Mullan H,Johnson MB,Sendamarai AK,Springel MW,Laurent B,Lehtinen MK

更新日期：2018-05-10 00:00:00

abstract：:Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia affecting geographically distant populations of two species of mussels (Mytilus chilensis in South America and M. edulis in Eur...

journal_title：eLife

authors： Yonemitsu MA,Giersch RM,Polo-Prieto M,Hammel M,Simon A,Cremonte F,Avilés FT,Merino-Véliz N,Burioli EA,Muttray AF,Sherry J,Reinisch C,Baldwin SA,Goff SP,Houssin M,Arriagada G,Vázquez N,Bierne N,Metzger MJ

更新日期：2019-11-05 00:00:00

abstract：:We present the development and in vivo application of a feedback-based tracking microscope to follow individual mitochondria in sensory neurons of zebrafish larvae with nanometer precision and millisecond temporal resolution. By combining various technical improvements, we tracked individual mitochondria with unpreced...

journal_title：eLife

authors： Wehnekamp F,Plucińska G,Thong R,Misgeld T,Lamb DC

更新日期：2019-06-10 00:00:00

abstract：:New data on the relationship between two proteins, cyclin D and Rb, suggest that we need to re-evaluate our understanding of how cells enter into the cell cycle. ...

journal_title：eLife

authors： Bertoli C,de Bruin RA

更新日期：2014-07-01 00:00:00

abstract：:Experience-dependent modifications of synaptic connections are thought to change patterns of network activities and stimulus tuning with learning. However, only a few studies explored how synaptic plasticity shapes the response dynamics of cortical circuits. Here, we investigated the mechanism underlying sharpening of...

journal_title：eLife

authors： Lim S

更新日期：2019-08-08 00:00:00

abstract：:Behavior relies on the ability of sensory systems to infer properties of the environment from incoming stimuli. The accuracy of inference depends on the fidelity with which behaviorally relevant properties of stimuli are encoded in neural responses. High-fidelity encodings can be metabolically costly, but low-fidelity...

journal_title：eLife

authors： Młynarski WF,Hermundstad AM

更新日期：2018-07-10 00:00:00

abstract：:Genome sequence data from a range of animal species are raising questions about the origins of glutamate receptors. ...

journal_title：eLife

authors： Mayer ML,Jegla T

更新日期：2018-12-28 00:00:00