Attention stabilizes the shared gain of V4 populations.


:Responses of sensory neurons represent stimulus information, but are also influenced by internal state. For example, when monkeys direct their attention to a visual stimulus, the response gain of specific subsets of neurons in visual cortex changes. Here, we develop a functional model of population activity to investigate the structure of this effect. We fit the model to the spiking activity of bilateral neural populations in area V4, recorded while the animal performed a stimulus discrimination task under spatial attention. The model reveals four separate time-varying shared modulatory signals, the dominant two of which each target task-relevant neurons in one hemisphere. In attention-directed conditions, the associated shared modulatory signal decreases in variance. This finding provides an interpretable and parsimonious explanation for previous observations that attention reduces variability and noise correlations of sensory neurons. Finally, the recovered modulatory signals reflect previous reward, and are predictive of subsequent choice behavior.






Rabinowitz NC,Goris RL,Cohen M,Simoncelli EP




Has Abstract


2015-11-02 00:00:00










  • An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP.

    abstract::TCF/LEF factors are ancient context-dependent enhancer-binding proteins that are activated by β-catenin following Wnt signaling. They control embryonic development and adult stem cell compartments, and their dysregulation often causes cancer. β-catenin-dependent transcription relies on the NPF motif of Pygo proteins. ...


    pub_type: 杂志文章


    authors: Fiedler M,Graeb M,Mieszczanek J,Rutherford TJ,Johnson CM,Bienz M

    更新日期:2015-08-27 00:00:00

  • Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer.

    abstract::Drug treatment of 3D cancer spheroids more accurately reflects in vivo therapeutic responses compared to adherent culture studies. In EGFR-mutated lung adenocarcinoma, EGFR-TKIs show enhanced efficacy in spheroid cultures. Simultaneous inhibition of multiple parallel RTKs further enhances EGFR-TKI effectiveness. We sh...


    pub_type: 杂志文章


    authors: Theard PL,Sheffels E,Sealover NE,Linke AJ,Pratico DJ,Kortum RL

    更新日期:2020-09-08 00:00:00

  • Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1.

    abstract::Termination of messenger RNA translation in Bacteria and Archaea is initiated by release factors (RFs) 1 or 2 recognizing a stop codon in the ribosomal A site and releasing the peptide from the P-site transfer RNA. After release, RF-dissociation is facilitated by the G-protein RF3. Structures of ribosomal complexes wi...


    pub_type: 杂志文章


    authors: Pallesen J,Hashem Y,Korkmaz G,Koripella RK,Huang C,Ehrenberg M,Sanyal S,Frank J

    更新日期:2013-06-04 00:00:00

  • Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function.

    abstract::Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes. Accordingly, T cells exhibited low basal glycolytic flux and limite...


    pub_type: 杂志文章


    authors: Bettonville M,d'Aria S,Weatherly K,Porporato PE,Zhang J,Bousbata S,Sonveaux P,Braun MY

    更新日期:2018-06-18 00:00:00

  • Circuit mechanisms encoding odors and driving aging-associated behavioral declines in Caenorhabditis elegans.

    abstract::Chemosensory neurons extract information about chemical cues from the environment. How is the activity in these sensory neurons transformed into behavior? Using Caenorhabditis elegans, we map a novel sensory neuron circuit motif that encodes odor concentration. Primary neurons, AWC(ON) and AWA, directly detect the foo...


    pub_type: 杂志文章


    authors: Leinwand SG,Yang CJ,Bazopoulou D,Chronis N,Srinivasan J,Chalasani SH

    更新日期:2015-09-22 00:00:00

  • Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Although rigorous efforts identified the presence of 'cancer stem cells (CSCs)' in PDAC and molecular markers for them, stem cell dynamics in vivo have not been clearly demonstrated. Here we focused on Doublecortin-like kinase 1 (Dclk1), known as a CSC ...


    pub_type: 杂志文章


    authors: Maruno T,Fukuda A,Goto N,Tsuda M,Ikuta K,Hiramatsu Y,Ogawa S,Nakanishi Y,Yamaga Y,Yoshioka T,Takaori K,Uemoto S,Saur D,Chiba T,Seno H

    更新日期:2021-01-04 00:00:00

  • Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation.

    abstract::Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication complexes with a CRISPR screen, to identify host factors required for norovirus infection. The c...


    pub_type: 杂志文章


    authors: Hosmillo M,Lu J,McAllaster MR,Eaglesham JB,Wang X,Emmott E,Domingues P,Chaudhry Y,Fitzmaurice TJ,Tung MK,Panas MD,McInerney G,Locker N,Wilen CB,Goodfellow IG

    更新日期:2019-08-12 00:00:00

  • Strong inter-population cooperation leads to partner intermixing in microbial communities.

    abstract::Patterns of spatial positioning of individuals within microbial communities are often critical to community function. However, understanding patterning in natural communities is hampered by the multitude of cell-cell and cell-environment interactions as well as environmental variability. Here, through simulations and ...


    pub_type: 杂志文章


    authors: Momeni B,Brileya KA,Fields MW,Shou W

    更新日期:2013-01-22 00:00:00

  • The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation.

    abstract::Nucleolar protein interacting with the FHA domain of pKi-67 (NIFK) is a Ki-67-interacting protein. However, its precise function in cancer remains largely uninvestigated. Here we show the clinical significance and metastatic mechanism of NIFK in lung cancer. NIFK expression is clinically associated with poor prognosis...


    pub_type: 杂志文章


    authors: Lin TC,Su CY,Wu PY,Lai TC,Pan WA,Jan YH,Chang YC,Yeh CT,Chen CL,Ger LP,Chang HT,Yang CJ,Huang MS,Liu YP,Lin YF,Shyy JY,Tsai MD,Hsiao M

    更新日期:2016-03-17 00:00:00

  • Evidence for transmission of COVID-19 prior to symptom onset.

    abstract::We collated contact tracing data from COVID-19 clusters in Singapore and Tianjin, China and estimated the extent of pre-symptomatic transmission by estimating incubation periods and serial intervals. The mean incubation periods accounting for intermediate cases were 4.91 days (95%CI 4.35, 5.69) and 7.54 (95%CI 6.76, 8...


    pub_type: 杂志文章


    authors: Tindale LC,Stockdale JE,Coombe M,Garlock ES,Lau WYV,Saraswat M,Zhang L,Chen D,Wallinga J,Colijn C

    更新日期:2020-06-22 00:00:00

  • Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages.

    abstract::How Mycobacterium tuberculosis (Mtb) rewires macrophage energy metabolism to facilitate survival is poorly characterized. Here, we used extracellular flux analysis to simultaneously measure the rates of glycolysis and respiration in real time. Mtb infection induced a quiescent energy phenotype in human monocyte-derive...


    pub_type: 杂志文章


    authors: Cumming BM,Addicott KW,Adamson JH,Steyn AJ

    更新日期:2018-11-16 00:00:00

  • Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure.

    abstract::Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological blood pressure and contribute to hypertension in vivo. We generate...


    pub_type: 杂志文章


    authors: Bulley S,Fernández-Peña C,Hasan R,Leo MD,Muralidharan P,Mackay CE,Evanson KW,Moreira-Junior L,Mata-Daboin A,Burris SK,Wang Q,Kuruvilla KP,Jaggar JH

    更新日期:2018-12-04 00:00:00

  • Magnetothermal genetic deep brain stimulation of motor behaviors in awake, freely moving mice.

    abstract::Establishing how neurocircuit activation causes particular behaviors requires modulating the activity of specific neurons. Here, we demonstrate that magnetothermal genetic stimulation provides tetherless deep brain activation sufficient to evoke motor behavior in awake mice. The approach uses alternating magnetic fiel...


    pub_type: 杂志文章


    authors: Munshi R,Qadri SM,Zhang Q,Castellanos Rubio I,Del Pino P,Pralle A

    更新日期:2017-08-15 00:00:00

  • Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons.

    abstract::Prion diseases are caused by PrPSc, a self-replicating pathologically misfolded protein that exerts toxicity predominantly in the brain. The administration of PrPSc causes a robust, reproducible and specific disease manifestation. Here, we have applied a combination of translating ribosome affinity purification and ri...


    pub_type: 杂志文章


    authors: Scheckel C,Imeri M,Schwarz P,Aguzzi A

    更新日期:2020-09-22 00:00:00

  • Control of entropy in neural models of environmental state.

    abstract::Humans and animals construct internal models of their environment in order to select appropriate courses of action. The representation of uncertainty about the current state of the environment is a key feature of these models that controls the rate of learning as well as directly affecting choice behaviour. To maintai...


    pub_type: 杂志文章


    authors: Muller TH,Mars RB,Behrens TE,O'Reilly JX

    更新日期:2019-02-28 00:00:00

  • A new answer to old questions.

    abstract::Sudden changes in the level of a coenzyme called NADPH might be the underlying cause of aging in cells. ...


    pub_type: 杂志文章


    authors: Barral Y

    更新日期:2013-02-05 00:00:00

  • Building customizable auto-luminescent luciferase-based reporters in plants.

    abstract::Bioluminescence is a powerful biological signal that scientists have repurposed as a reporter for gene expression in plants and animals. However, there are downsides associated with the need to provide a substrate to these reporters, including its high cost and non-uniform tissue penetration. In this work we reconstit...


    pub_type: 杂志文章


    authors: Khakhar A,Starker CG,Chamness JC,Lee N,Stokke S,Wang C,Swanson R,Rizvi F,Imaizumi T,Voytas DF

    更新日期:2020-03-25 00:00:00

  • Epimutations are associated with CHROMOMETHYLASE 3-induced de novo DNA methylation.

    abstract::In many plant species, a subset of transcribed genes are characterized by strictly CG-context DNA methylation, referred to as gene body methylation (gbM). The mechanisms that establish gbM are unclear, yet flowering plant species naturally without gbM lack the DNA methyltransferase, CMT3, which maintains CHG (H = A, C...


    pub_type: 杂志文章


    authors: Wendte JM,Zhang Y,Ji L,Shi X,Hazarika RR,Shahryary Y,Johannes F,Schmitz RJ

    更新日期:2019-07-29 00:00:00

  • Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo.

    abstract::Though neurotransmitters are essential elements in neuronal signal transduction, techniques for in vivo analysis are still limited. Here, we describe an organic electrochemical transistor array (OECT-array) technique for monitoring catecholamine neurotransmitters (CA-NTs) in rat brains. The OECT-array is an active sen...


    pub_type: 杂志文章


    authors: Xie K,Wang N,Lin X,Wang Z,Zhao X,Fang P,Yue H,Kim J,Luo J,Cui S,Yan F,Shi P

    更新日期:2020-02-11 00:00:00

  • A stable mode of bookmarking by TBP recruits RNA polymerase II to mitotic chromosomes.

    abstract::Maintenance of transcription programs is challenged during mitosis when chromatin becomes condensed and transcription is silenced. How do the daughter cells re-establish the original transcription program? Here, we report that the TATA-binding protein (TBP), a key component of the core transcriptional machinery, remai...


    pub_type: 杂志文章


    authors: Teves SS,An L,Bhargava-Shah A,Xie L,Darzacq X,Tjian R

    更新日期:2018-06-25 00:00:00

  • Adaptation in protein fitness landscapes is facilitated by indirect paths.

    abstract::The structure of fitness landscapes is critical for understanding adaptive protein evolution. Previous empirical studies on fitness landscapes were confined to either the neighborhood around the wild type sequence, involving mostly single and double mutants, or a combinatorially complete subgraph involving only two am...


    pub_type: 杂志文章


    authors: Wu NC,Dai L,Olson CA,Lloyd-Smith JO,Sun R

    更新日期:2016-07-08 00:00:00

  • DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.

    abstract::The circadian transcriptional repressors cryptochrome 1 (Cry1) and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this study, we report that while they have lost DNA repair activity, Cry1/2 adapted to protect genomic integrity by responding to DNA damage through posttranslational m...


    pub_type: 杂志文章


    authors: Papp SJ,Huber AL,Jordan SD,Kriebs A,Nguyen M,Moresco JJ,Yates JR,Lamia KA

    更新日期:2015-03-10 00:00:00

  • Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex.

    abstract::Complexin regulates spontaneous and activates Ca(2+)-triggered neurotransmitter release, yet the molecular mechanisms are still unclear. Here we performed single molecule fluorescence resonance energy transfer experiments and uncovered two conformations of complexin-1 bound to the ternary SNARE complex. In the cis con...


    pub_type: 杂志文章


    authors: Choi UB,Zhao M,Zhang Y,Lai Y,Brunger AT

    更新日期:2016-06-02 00:00:00

  • Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis.

    abstract::Intermittent hypoxia (IH) is the predominant pathophysiological disturbance in obstructive sleep apnea (OSA), known to be independently associated with cardiovascular diseases. However, the effect of IH on cardiac fibrosis and molecular events involved in this process are unclear. Here, we tested IH in angiotensin II ...


    pub_type: 杂志文章


    authors: Bao Q,Zhang B,Suo Y,Liu C,Yang Q,Zhang K,Yuan M,Yuan M,Zhang Y,Li G

    更新日期:2020-01-14 00:00:00

  • Plasticity and evolutionary convergence in the locomotor skeleton of Greater Antillean Anolis lizards.

    abstract::Plasticity can put evolution on repeat if development causes species to generate similar morphologies in similar environments. Anolis lizards offer the opportunity to put this role of developmental plasticity to the test. Following colonization of the four Greater Antillean islands, Anolis lizards independently and re...


    pub_type: 杂志文章


    authors: Feiner N,Jackson IS,Munch KL,Radersma R,Uller T

    更新日期:2020-08-13 00:00:00

  • Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization.

    abstract::Skeletal muscle degeneration is a complication arising from a variety of chronic diseases including advanced cancer. Pro-inflammatory cytokine TNF-α plays a pivotal role in mediating cancer-related skeletal muscle degeneration. Here, we show a novel function for retinoblastoma protein (Rb), where Rb causes sarcomeric ...


    pub_type: 杂志文章


    authors: Araki K,Kawauchi K,Hirata H,Yamamoto M,Taya Y

    更新日期:2013-12-03 00:00:00

  • Cannabidiol interactions with voltage-gated sodium channels.

    abstract::Voltage-gated sodium channels are targets for a range of pharmaceutical drugs developed for the treatment of neurological diseases. Cannabidiol (CBD), the non-psychoactive compound isolated from cannabis plants, was recently approved for treatment of two types of epilepsy associated with sodium channel mutations. This...


    pub_type: 杂志文章


    authors: Sait LG,Sula A,Ghovanloo MR,Hollingworth D,Ruben PC,Wallace BA

    更新日期:2020-10-22 00:00:00

  • Towards a mechanistic foundation of evolutionary theory.

    abstract::Most evolutionary thinking is based on the notion of fitness and related ideas such as fitness landscapes and evolutionary optima. Nevertheless, it is often unclear what fitness actually is, and its meaning often depends on the context. Here we argue that fitness should not be a basal ingredient in verbal or mathemati...


    pub_type: 杂志文章


    authors: Doebeli M,Ispolatov Y,Simon B

    更新日期:2017-02-15 00:00:00

  • Does diversity beget diversity in microbiomes?

    abstract::Microbes are embedded in complex communities where they engage in a wide array of intra- and inter-specific interactions. The extent to which these interactions drive or impede microbiome diversity is not well understood. Historically, two contrasting hypotheses have been suggested to explain how species interactions ...


    pub_type: 杂志文章


    authors: Madi N,Vos M,Murall CL,Legendre P,Shapiro BJ

    更新日期:2020-11-20 00:00:00

  • Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse.

    abstract::Understanding the molecular mechanism of glaucoma and development of neuroprotectants is significantly hindered by the lack of a reliable animal model that accurately recapitulates human glaucoma. Here, we sought to develop a mouse model for the secondary glaucoma that is often observed in humans after silicone oil (S...


    pub_type: 杂志文章


    authors: Zhang J,Li L,Huang H,Fang F,Webber HC,Zhuang P,Liu L,Dalal R,Tang PH,Mahajan VB,Sun Y,Li S,Zhang M,Goldberg JL,Hu Y

    更新日期:2019-05-15 00:00:00