Abstract:
:Responses of sensory neurons represent stimulus information, but are also influenced by internal state. For example, when monkeys direct their attention to a visual stimulus, the response gain of specific subsets of neurons in visual cortex changes. Here, we develop a functional model of population activity to investigate the structure of this effect. We fit the model to the spiking activity of bilateral neural populations in area V4, recorded while the animal performed a stimulus discrimination task under spatial attention. The model reveals four separate time-varying shared modulatory signals, the dominant two of which each target task-relevant neurons in one hemisphere. In attention-directed conditions, the associated shared modulatory signal decreases in variance. This finding provides an interpretable and parsimonious explanation for previous observations that attention reduces variability and noise correlations of sensory neurons. Finally, the recovered modulatory signals reflect previous reward, and are predictive of subsequent choice behavior.
journal_name
Elifejournal_title
eLifeauthors
Rabinowitz NC,Goris RL,Cohen M,Simoncelli EPdoi
10.7554/eLife.08998subject
Has Abstractpub_date
2015-11-02 00:00:00pages
e08998issn
2050-084Xjournal_volume
4pub_type
杂志文章相关文献
eLife文献大全abstract::The immediate evolutionary space accessible to HIV is largely determined by how single amino acid mutations affect fitness. These mutational effects can shift as the virus evolves. However, the prevalence of such shifts in mutational effects remains unclear. Here, we quantify the effects on viral growth of all amino a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34420
更新日期:2018-03-28 00:00:00
abstract::Though neurotransmitters are essential elements in neuronal signal transduction, techniques for in vivo analysis are still limited. Here, we describe an organic electrochemical transistor array (OECT-array) technique for monitoring catecholamine neurotransmitters (CA-NTs) in rat brains. The OECT-array is an active sen...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.50345
更新日期:2020-02-11 00:00:00
abstract::Multiple studies have reported a male bias in incidence and/or prevalence of malaria infection in males compared to females. To test the hypothesis that sex-based differences in host-parasite interactions affect the epidemiology of malaria, we intensively followed Plasmodium falciparum infections in a cohort in a mala...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59872
更新日期:2020-10-27 00:00:00
abstract::TMEM16F is activated by elevated intracellular Ca2+, and functions as a small-conductance ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as a cation-, anion-, or non-selective ion channel, without a definite ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.45187
更新日期:2019-07-18 00:00:00
abstract::Aberrant expression of cancer genes and non-canonical RNA species is a hallmark of cancer. However, the mechanisms driving such atypical gene expression programs are incompletely understood. Here, our transcriptional profiling of a cohort of 50 primary clear cell renal cell carcinoma (ccRCC) samples from The Cancer Ge...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09214
更新日期:2015-11-17 00:00:00
abstract::Vitamin B12 (cobalamin) is the most complex B-type vitamin and is synthetized exclusively in a limited number of prokaryotes. Its biologically active variants contain rare organometallic bonds, which are used by enzymes in a variety of central metabolic pathways such as L-methionine synthesis and ribonucleotide reduct...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35828
更新日期:2018-05-29 00:00:00
abstract::The vertebral column or spine assembles around the notochord rod which contains a core made of large vacuolated cells. Each vacuolated cell possesses a single fluid-filled vacuole, and loss or fragmentation of these vacuoles in zebrafish leads to spine kinking. Here, we identified a mutation in the kinase gene dstyk tha...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51221
更新日期:2020-01-29 00:00:00
abstract::The multi-domain splicing factor RBM5 regulates the balance between antagonistic isoforms of the apoptosis-control genes FAS/CD95, Caspase-2 and AID. An OCRE (OCtamer REpeat of aromatic residues) domain found in RBM5 is important for alternative splicing regulation and mediates interactions with components of the U4/U...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14707
更新日期:2016-11-29 00:00:00
abstract::A pair of neurons is required for nematodes to be able to navigate using the Earth's magnetic field. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.09666
更新日期:2015-08-05 00:00:00
abstract::The factors that govern assembly of the gut microbiota are insufficiently understood. Here, we test the hypothesis that inter-individual microbiota variation can arise solely from differences in the order and timing by which the gut is colonized early in life. Experiments in which mice were inoculated in sequence eith...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36521
更新日期:2018-09-18 00:00:00
abstract::Viral replicase recruitment and long-range RNA interactions are essential for RNA virus replication, yet the mechanism of their interplay remains elusive. Flaviviruses include numerous important human pathogens, e.g., dengue virus (DENV) and Zika virus (ZIKV). Here, we revealed a highly conserved, conformation-tunable...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.17636
更新日期:2016-10-01 00:00:00
abstract::Acquisition of pluripotency is driven largely at the transcriptional level by activators OCT4, SOX2, and NANOG that must in turn cooperate with diverse coactivators to execute stem cell-specific gene expression programs. Using a biochemically defined in vitro transcription system that mediates OCT4/SOX2 and coactivato...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03573
更新日期:2014-11-19 00:00:00
abstract::Although respiratory syncytial virus (RSV) is responsible for more human deaths each year than influenza, its pathogenic mechanisms are poorly understood. Here high-resolution quantitative imaging, bioenergetics measurements and mitochondrial membrane potential- and redox-sensitive dyes are used to define RSV's impact...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.42448
更新日期:2019-06-27 00:00:00
abstract::Gene transcription can be activated by decreasing the duration of RNA polymerase II pausing in the promoter-proximal region, but how this is achieved remains unclear. Here we use a 'multi-omics' approach to demonstrate that the duration of polymerase pausing generally limits the productive frequency of transcription i...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.29736
更新日期:2017-10-10 00:00:00
abstract::In endoplasmic reticulum-associated protein degradation (ERAD), membrane proteins are ubiquitinated, extracted from the membrane, and degraded by the proteasome. The cytosolic ATPase Cdc48 drives extraction by pulling on polyubiquitinated substrates. How hydrophobic transmembrane (TM) segments are moved from the phosp...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56945
更新日期:2020-06-26 00:00:00
abstract::The mammalian auditory sensory epithelium has one of the most stereotyped cellular patterns known in vertebrates. Mechano-sensory hair cells are arranged in precise rows, with one row of inner and three rows of outer hair cells spanning the length of the spiral-shaped sensory epithelium. Aiding such precise cellular p...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47613
更新日期:2019-06-12 00:00:00
abstract:: ...
journal_title:eLife
pub_type: 杂志文章,已发布勘误
doi:10.7554/eLife.60401
更新日期:2020-06-30 00:00:00
abstract::Wnt plays important role during development and in various diseases. Because Wnts are lipidated and highly hydrophobic, they can only be purified in the presence of detergents, limiting their use in various in vitro and in vivo assays. We purified N-terminally tagged recombinant Wnt3a secreted from cells and accidenta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11621
更新日期:2016-02-23 00:00:00
abstract::Building a genotype-phenotype-fitness map of adaptation is a central goal in evolutionary biology. It is difficult even when adaptive mutations are known because it is hard to enumerate which phenotypes make these mutations adaptive. We address this problem by first quantifying how the fitness of hundreds of adaptive ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.61271
更新日期:2020-12-02 00:00:00
abstract::The spliceosome is a complex machine composed of small nuclear ribonucleoproteins (snRNPs) and accessory proteins that excises introns from pre-mRNAs. After assembly the spliceosome is activated for catalysis by rearrangement of subunits to form an active site. How this rearrangement is coordinated is not well-underst...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14166
更新日期:2016-05-31 00:00:00
abstract::How Mycobacterium tuberculosis (Mtb) rewires macrophage energy metabolism to facilitate survival is poorly characterized. Here, we used extracellular flux analysis to simultaneously measure the rates of glycolysis and respiration in real time. Mtb infection induced a quiescent energy phenotype in human monocyte-derive...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39169
更新日期:2018-11-16 00:00:00
abstract::Dietary restriction increases the longevity of many organisms, but the cell signaling and organellar mechanisms underlying this capability are unclear. We demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast cells activate lipid-droplet (LD) consumption through micro-lipophagy (...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21690
更新日期:2017-04-10 00:00:00
abstract::Breast cancer stem cells (BCSCs) contribute to intra-tumoral heterogeneity and therapeutic resistance. However, the binary concept of universal BCSCs co-existing with bulk tumor cells is over-simplified. Through single-cell RNA-sequencing, we found that Neu, PyMT and BRCA1-null mammary tumors each corresponded to a sp...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58810
更新日期:2020-08-25 00:00:00
abstract::Oligomeric assemblies of intraflagellar transport (IFT) particles build cilia through sequential recruitment and transport of ciliary cargo proteins within cilia. Here we present the 1.8 Å resolution crystal structure of the Chlamydomonas IFT-B protein IFT80, which reveals the architecture of two N-terminal β-propelle...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.33067
更新日期:2018-04-16 00:00:00
abstract::As part of the Reproducibility Project: Cancer Biology, we published a Registered Report (Blum et al., 2015), that described how we intended to replicate selected experiments from the paper 'Transcriptional amplification in tumor cells with elevated c-Myc' (Lin et al., 2012). Here we report the results. We found overe...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30274
更新日期:2018-01-09 00:00:00
abstract::Dietary magnesium (Mg2+) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg2+ feeding also enhances long-term memory ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.61339
更新日期:2020-11-26 00:00:00
abstract::Optogenetic approaches are leading to a better understanding of the forces that determine the plane of cell division. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.38748
更新日期:2018-07-09 00:00:00
abstract::Many postdoctoral researchers apply for faculty positions knowing relatively little about the hiring process or what is needed to secure a job offer. To address this lack of knowledge about the hiring process we conducted a survey of applicants for faculty positions: the survey ran between May 2018 and May 2019, and r...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54097
更新日期:2020-06-12 00:00:00
abstract::Sex-specific synaptic connectivity is beginning to emerge as a remarkable, but little explored feature of animal brains. We describe here a novel mechanism that promotes sexually dimorphic neuronal function and synaptic connectivity in the nervous system of the nematode Caenorhabditis elegans. We demonstrate that a ph...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59614
更新日期:2020-10-06 00:00:00
abstract::Dorsal/ventral (DV) patterning of the sea urchin embryo relies on a ventrally-localized organizer expressing Nodal, a pivotal regulator of the DV gene regulatory network. However, the inceptive mechanisms imposing the symmetry-breaking are incompletely understood. In Paracentrotus lividus, the Hbox12 homeodomain-conta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04664
更新日期:2014-12-02 00:00:00