Attention stabilizes the shared gain of V4 populations.


:Responses of sensory neurons represent stimulus information, but are also influenced by internal state. For example, when monkeys direct their attention to a visual stimulus, the response gain of specific subsets of neurons in visual cortex changes. Here, we develop a functional model of population activity to investigate the structure of this effect. We fit the model to the spiking activity of bilateral neural populations in area V4, recorded while the animal performed a stimulus discrimination task under spatial attention. The model reveals four separate time-varying shared modulatory signals, the dominant two of which each target task-relevant neurons in one hemisphere. In attention-directed conditions, the associated shared modulatory signal decreases in variance. This finding provides an interpretable and parsimonious explanation for previous observations that attention reduces variability and noise correlations of sensory neurons. Finally, the recovered modulatory signals reflect previous reward, and are predictive of subsequent choice behavior.






Rabinowitz NC,Goris RL,Cohen M,Simoncelli EP




Has Abstract


2015-11-02 00:00:00










  • ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly.

    abstract::Oncogenic human papillomaviruses (HPV) are small DNA viruses that infect keratinocytes. After HPV binding to cell surface receptors, a cascade of molecular interactions mediates the infectious cellular internalization of virus particles. Aside from the virus itself, important molecular players involved in virus entry ...


    pub_type: 杂志文章


    authors: Mikuličić S,Finke J,Boukhallouk F,Wüstenhagen E,Sons D,Homsi Y,Reiss K,Lang T,Florin L

    更新日期:2019-05-20 00:00:00

  • Cell non-autonomous regulation of health and longevity.

    abstract::As the demographics of the modern world skew older, understanding and mitigating the effects of aging is increasingly important within biomedical research. Recent studies in model organisms demonstrate that the aging process is frequently modified by an organism's ability to perceive and respond to changes in its envi...


    pub_type: 杂志文章


    authors: Miller HA,Dean ES,Pletcher SD,Leiser SF

    更新日期:2020-12-10 00:00:00

  • Diminished responses to bodily threat and blunted interoception in suicide attempters.

    abstract::Psychological theories of suicide suggest that certain traits may reduce aversion to physical threat and increase the probability of transitioning from suicidal ideation to action. Here, we investigated whether blunted sensitivity to bodily signals is associated with suicidal action by comparing individuals with a his...


    pub_type: 杂志文章


    authors: DeVille DC,Kuplicki R,Stewart JL,Tulsa 1000 Investigators.,Paulus MP,Khalsa SS

    更新日期:2020-04-07 00:00:00

  • ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis.

    abstract::A well-established cascade of transcription factor (TF) activity orchestrates adipogenesis in response to chemical cues, yet how cell-intrinsic determinants of differentiation such as cell shape and/or seeding density inform this transcriptional program remain enigmatic. Here, we uncover a novel mechanism licensing tr...


    pub_type: 杂志文章


    authors: Cohen DM,Won KJ,Nguyen N,Lazar MA,Chen CS,Steger DJ

    更新日期:2015-06-25 00:00:00

  • Palaeogenomes of Eurasian straight-tusked elephants challenge the current view of elephant evolution.

    abstract::The straight-tusked elephants Palaeoloxodon spp. were widespread across Eurasia during the Pleistocene. Phylogenetic reconstructions using morphological traits have grouped them with Asian elephants (Elephas maximus), and many paleontologists place Palaeoloxodon within Elephas. Here, we report the recovery of full mit...


    pub_type: 杂志文章


    authors: Meyer M,Palkopoulou E,Baleka S,Stiller M,Penkman KEH,Alt KW,Ishida Y,Mania D,Mallick S,Meijer T,Meller H,Nagel S,Nickel B,Ostritz S,Rohland N,Schauer K,Schüler T,Roca AL,Reich D,Shapiro B,Hofreiter M

    更新日期:2017-06-06 00:00:00

  • Nucleosome breathing and remodeling constrain CRISPR-Cas9 function.

    abstract::The CRISPR-Cas9 bacterial surveillance system has become a versatile tool for genome editing and gene regulation in eukaryotic cells, yet how CRISPR-Cas9 contends with the barriers presented by eukaryotic chromatin is poorly understood. Here we investigate how the smallest unit of chromatin, a nucleosome, constrains t...


    pub_type: 杂志文章


    authors: Isaac RS,Jiang F,Doudna JA,Lim WA,Narlikar GJ,Almeida R

    更新日期:2016-04-28 00:00:00

  • CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold.

    abstract::The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase. Until now, the regulation that restricts CMG ubiquitylation to terminatio...


    pub_type: 杂志文章


    authors: Deegan TD,Mukherjee PP,Fujisawa R,Polo Rivera C,Labib K

    更新日期:2020-08-17 00:00:00

  • Calcium-mediated actin reset (CaAR) mediates acute cell adaptations.

    abstract::Actin has well established functions in cellular morphogenesis. However, it is not well understood how the various actin assemblies in a cell are kept in a dynamic equilibrium, in particular when cells have to respond to acute signals. Here, we characterize a rapid and transient actin reset in response to increased in...


    pub_type: 杂志文章


    authors: Wales P,Schuberth CE,Aufschnaiter R,Fels J,García-Aguilar I,Janning A,Dlugos CP,Schäfer-Herte M,Klingner C,Wälte M,Kuhlmann J,Menis E,Hockaday Kang L,Maier KC,Hou W,Russo A,Higgs HN,Pavenstädt H,Vogl T,Roth J,Qual

    更新日期:2016-12-06 00:00:00

  • Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior.

    abstract::Habit formation is a behavioral adaptation that automates routine actions. Habitual behavior correlates with broad reconfigurations of dorsolateral striatal (DLS) circuit properties that increase gain and shift pathway timing. The mechanism(s) for these circuit adaptations are unknown and could be responsible for habi...


    pub_type: 杂志文章


    authors: O'Hare JK,Li H,Kim N,Gaidis E,Ade K,Beck J,Yin H,Calakos N

    更新日期:2017-09-05 00:00:00

  • A common mechanism underlies changes of mind about decisions and confidence.

    abstract::Decisions are accompanied by a degree of confidence that a selected option is correct. A sequential sampling framework explains the speed and accuracy of decisions and extends naturally to the confidence that the decision rendered is likely to be correct. However, discrepancies between confidence and accuracy suggest ...


    pub_type: 杂志文章


    authors: van den Berg R,Anandalingam K,Zylberberg A,Kiani R,Shadlen MN,Wolpert DM

    更新日期:2016-02-01 00:00:00

  • Large protein organelles form a new iron sequestration system with high storage capacity.

    abstract::Iron storage proteins are essential for cellular iron homeostasis and redox balance. Ferritin proteins are the major storage units for bioavailable forms of iron. Some organisms lack ferritins, and it is not known how they store iron. Encapsulins, a class of protein-based organelles, have recently been implicated in m...


    pub_type: 杂志文章


    authors: Giessen TW,Orlando BJ,Verdegaal AA,Chambers MG,Gardener J,Bell DC,Birrane G,Liao M,Silver PA

    更新日期:2019-07-08 00:00:00

  • The functional organization of descending sensory-motor pathways in Drosophila.

    abstract::In most animals, the brain controls the body via a set of descending neurons (DNs) that traverse the neck. DN activity activates, maintains or modulates locomotion and other behaviors. Individual DNs have been well-studied in species from insects to primates, but little is known about overall connectivity patterns acr...


    pub_type: 杂志文章


    authors: Namiki S,Dickinson MH,Wong AM,Korff W,Card GM

    更新日期:2018-06-26 00:00:00

  • De-repression of the RAC activator ELMO1 in cancer stem cells drives progression of TGFβ-deficient squamous cell carcinoma from transition zones.

    abstract::Squamous cell carcinomas occurring at transition zones are highly malignant tumors with poor prognosis. The identity of the cell population and the signaling pathways involved in the progression of transition zone squamous cell carcinoma are poorly understood, hence representing limited options for targeted therapies....


    pub_type: 杂志文章


    authors: McCauley HA,Chevrier V,Birnbaum D,Guasch G

    更新日期:2017-02-21 00:00:00

  • Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways.

    abstract::Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving cytotoxic conformations of Cu, Zn superoxide dismutase (SOD1). A major challenge in understanding ALS disease pathology has been the identification and atomic-level characterization of these conformers. Here, we use a combination ...


    pub_type: 杂志文章


    authors: Sekhar A,Rumfeldt JA,Broom HR,Doyle CM,Bouvignies G,Meiering EM,Kay LE

    更新日期:2015-06-23 00:00:00

  • Analysis of SUMO1-conjugation at synapses.

    abstract::SUMO1-conjugation of proteins at neuronal synapses is considered to be a major post-translational regulatory process in nerve cell and synapse function, but the published evidence for SUMO1-conjugation at synapses is contradictory. We employed multiple genetic mouse models for stringently controlled biochemical and im...


    pub_type: 杂志文章


    authors: Daniel JA,Cooper BH,Palvimo JJ,Zhang FP,Brose N,Tirard M

    更新日期:2017-06-09 00:00:00

  • Assembling the Tat protein translocase.

    abstract::The twin-arginine protein translocation system (Tat) transports folded proteins across the bacterial cytoplasmic membrane and the thylakoid membranes of plant chloroplasts. The Tat transporter is assembled from multiple copies of the membrane proteins TatA, TatB, and TatC. We combine sequence co-evolution analysis, mo...


    pub_type: 杂志文章


    authors: Alcock F,Stansfeld PJ,Basit H,Habersetzer J,Baker MA,Palmer T,Wallace MI,Berks BC

    更新日期:2016-12-03 00:00:00

  • Mapping residual transmission for malaria elimination.

    abstract::Eliminating malaria from a defined region involves draining the endemic parasite reservoir and minimizing local malaria transmission around imported malaria infections . In the last phases of malaria elimination, as universal interventions reap diminishing marginal returns, national resources must become increasingly ...


    pub_type: 杂志文章


    authors: Reiner RC,Le Menach A,Kunene S,Ntshalintshali N,Hsiang MS,Perkins TA,Greenhouse B,Tatem AJ,Cohen JM,Smith DL

    更新日期:2015-12-29 00:00:00

  • Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration.

    abstract::Axolotls are uniquely able to mobilize neural stem cells to regenerate all missing regions of the spinal cord. How a neural stem cell under homeostasis converts after injury to a highly regenerative cell remains unknown. Here, we show that during regeneration, axolotl neural stem cells repress neurogenic genes and rea...


    pub_type: 杂志文章


    authors: Rodrigo Albors A,Tazaki A,Rost F,Nowoshilow S,Chara O,Tanaka EM

    更新日期:2015-11-14 00:00:00

  • Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition.

    abstract::Malaria infection starts with injection of Plasmodium sporozoites by an Anopheles mosquito into the skin of the mammalian host. How sporozoites locate and enter a blood vessel is a critical, but poorly understood process. In this study, we examine sporozoite motility and their interaction with dermal blood vessels, us...


    pub_type: 杂志文章


    authors: Hopp CS,Chiou K,Ragheb DR,Salman AM,Khan SM,Liu AJ,Sinnis P

    更新日期:2015-08-13 00:00:00

  • Trisomy 21 consistently activates the interferon response.

    abstract::Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently activated by trisomy 21 in human cells. Transcriptome analysis rev...


    pub_type: 杂志文章


    authors: Sullivan KD,Lewis HC,Hill AA,Pandey A,Jackson LP,Cabral JM,Smith KP,Liggett LA,Gomez EB,Galbraith MD,DeGregori J,Espinosa JM

    更新日期:2016-07-29 00:00:00

  • ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis.

    abstract::Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR-mediated chloride and bicarbonate transport, with dysregulation of epithelial sodium channels (ENaC). These changes alter fluid and electrolyte homeostasis...


    pub_type: 杂志文章


    authors: Scambler T,Jarosz-Griffiths HH,Lara-Reyna S,Pathak S,Wong C,Holbrook J,Martinon F,Savic S,Peckham D,McDermott MF

    更新日期:2019-09-18 00:00:00

  • Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock.

    abstract::Segmentation of the axial skeleton in amniotes depends on the segmentation clock, which patterns the paraxial mesoderm and the sclerotome. While the segmentation clock clearly operates in teleosts, the role of the sclerotome in establishing the axial skeleton is unclear. We severely disrupt zebrafish paraxial segmenta...


    pub_type: 杂志文章


    authors: Lleras Forero L,Narayanan R,Huitema LF,VanBergen M,Apschner A,Peterson-Maduro J,Logister I,Valentin G,Morelli LG,Oates AC,Schulte-Merker S

    更新日期:2018-04-06 00:00:00

  • Ser/Thr kinase Trc controls neurite outgrowth in Drosophila by modulating microtubule-microtubule sliding.

    abstract::Correct neuronal development requires tailored neurite outgrowth. Neurite outgrowth is driven in part by microtubule-sliding - the transport of microtubules along each other. We have recently demonstrated that a 'mitotic' kinesin-6 (Pavarotti in Drosophila) effectively inhibits microtubule-sliding and neurite outgrowt...


    pub_type: 杂志文章


    authors: Norkett R,Del Castillo U,Lu W,Gelfand VI

    更新日期:2020-02-05 00:00:00

  • The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation.

    abstract::Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic evolution. Whereas the molecular architecture of SAS-6 and its role...


    pub_type: 杂志文章


    authors: Rogala KB,Dynes NJ,Hatzopoulos GN,Yan J,Pong SK,Robinson CV,Deane CM,Gönczy P,Vakonakis I

    更新日期:2015-05-29 00:00:00

  • Gene autoregulation by 3' UTR-derived bacterial small RNAs.

    abstract::Negative feedback regulation, that is the ability of a gene to repress its own synthesis, is the most abundant regulatory motif known to biology. Frequently reported for transcriptional regulators, negative feedback control relies on binding of a transcription factor to its own promoter. Here, we report a novel mechan...


    pub_type: 杂志文章


    authors: Hoyos M,Huber M,Förstner KU,Papenfort K

    更新日期:2020-08-03 00:00:00

  • Arabidopsis plants perform arithmetic division to prevent starvation at night.

    abstract::Photosynthetic starch reserves that accumulate in Arabidopsis leaves during the day decrease approximately linearly with time at night to support metabolism and growth. We find that the rate of decrease is adjusted to accommodate variation in the time of onset of darkness and starch content, such that reserves last al...


    pub_type: 杂志文章


    authors: Scialdone A,Mugford ST,Feike D,Skeffington A,Borrill P,Graf A,Smith AM,Howard M

    更新日期:2013-06-25 00:00:00

  • Distinct effects of prefrontal and parietal cortex inactivations on an accumulation of evidence task in the rat.

    abstract::Numerous brain regions have been shown to have neural correlates of gradually accumulating evidence for decision-making, but the causal roles of these regions in decisions driven by accumulation of evidence have yet to be determined. Here, in rats performing an auditory evidence accumulation task, we inactivated the f...


    pub_type: 杂志文章


    authors: Erlich JC,Brunton BW,Duan CA,Hanks TD,Brody CD

    更新日期:2015-04-14 00:00:00

  • The neuropeptide tachykinin is essential for pheromone detection in a gustatory neural circuit.

    abstract::Gustatory pheromones play an essential role in shaping the behavior of many organisms. However, little is known about the processing of taste pheromones in higher order brain centers. Here, we describe a male-specific gustatory circuit in Drosophila that underlies the detection of the anti-aphrodisiac pheromone (3R,11...


    pub_type: 杂志文章


    authors: Shankar S,Chua JY,Tan KJ,Calvert ME,Weng R,Ng WC,Mori K,Yew JY

    更新日期:2015-06-17 00:00:00

  • Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.

    abstract::Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover of metabolites relative to the time needed to isolate cells. To overcome this cha...


    pub_type: 杂志文章


    authors: Lau AN,Li Z,Danai LV,Westermark AM,Darnell AM,Ferreira R,Gocheva V,Sivanand S,Lien EC,Sapp KM,Mayers JR,Biffi G,Chin CR,Davidson SM,Tuveson DA,Jacks T,Matheson NJ,Yilmaz O,Vander Heiden MG

    更新日期:2020-07-10 00:00:00

  • Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation.

    abstract::Knowledge of the host factors required for norovirus replication has been hindered by the challenges associated with culturing human noroviruses. We have combined proteomic analysis of the viral translation and replication complexes with a CRISPR screen, to identify host factors required for norovirus infection. The c...


    pub_type: 杂志文章


    authors: Hosmillo M,Lu J,McAllaster MR,Eaglesham JB,Wang X,Emmott E,Domingues P,Chaudhry Y,Fitzmaurice TJ,Tung MK,Panas MD,McInerney G,Locker N,Wilen CB,Goodfellow IG

    更新日期:2019-08-12 00:00:00