Ionic mechanisms underlying history-dependence of conduction delay in an unmyelinated axon.

Abstract:

:Axonal conduction velocity can change substantially during ongoing activity, thus modifying spike interval structures and, potentially, temporal coding. We used a biophysical model to unmask mechanisms underlying the history-dependence of conduction. The model replicates activity in the unmyelinated axon of the crustacean stomatogastric pyloric dilator neuron. At the timescale of a single burst, conduction delay has a non-monotonic relationship with instantaneous frequency, which depends on the gating rates of the fast voltage-gated Na+ current. At the slower timescale of minutes, the mean value and variability of conduction delay increase. These effects are because of hyperpolarization of the baseline membrane potential by the Na+/K+ pump, balanced by an h-current, both of which affect the gating of the Na+ current. We explore the mechanisms of history-dependence of conduction delay in axons and develop an empirical equation that accurately predicts this history-dependence, both in the model and in experimental measurements.

journal_name

Elife

journal_title

eLife

authors

Zhang Y,Bucher D,Nadim F

doi

10.7554/eLife.25382

subject

Has Abstract

pub_date

2017-07-10 00:00:00

issn

2050-084X

journal_volume

6

pub_type

杂志文章

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