Abstract:
:We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.
journal_name
Elifejournal_title
eLifeauthors
Díaz-Alonso J,Morishita W,Incontro S,Simms J,Holtzman J,Gill M,Mucke L,Malenka RC,Nicoll RAdoi
10.7554/eLife.58042subject
Has Abstractpub_date
2020-08-24 00:00:00issn
2050-084Xpii
58042journal_volume
9pub_type
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