mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding.

abstract：:Meiotic drive is the preferential transmission of a particular allele during sexual reproduction. The phenomenon is observed as spore killing in multiple fungi. In natural populations of Podospora anserina, seven spore killer types (Psks) have been identified through classical genetic analyses. Here we show that the S...

journal_title：eLife

authors： Vogan AA,Ament-Velásquez SL,Granger-Farbos A,Svedberg J,Bastiaans E,Debets AJ,Coustou V,Yvanne H,Clavé C,Saupe SJ,Johannesson H

更新日期：2019-07-26 00:00:00

abstract：:Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. Here, we demonstrate that chromatin-associated RNA contributes to the stable association of SUV39H...

journal_title：eLife

authors： Johnson WL,Yewdell WT,Bell JC,McNulty SM,Duda Z,O'Neill RJ,Sullivan BA,Straight AF

更新日期：2017-08-01 00:00:00

abstract：:The central complex is a highly conserved insect brain region composed of morphologically stereotyped neurons that arborize in distinctively shaped substructures. The region is implicated in a wide range of behaviors and several modeling studies have explored its circuit computations. Most studies have relied on assum...

journal_title：eLife

authors： Franconville R,Beron C,Jayaraman V

更新日期：2018-08-20 00:00:00

abstract：:Axons span extreme distances and are subject to significant stretch deformations during limb movements or sudden head movements, especially during impacts. Yet, axon biomechanics, and its relation to the ultrastructure that allows axons to withstand mechanical stress, is poorly understood. Using a custom developed for...

journal_title：eLife

authors： Dubey S,Bhembre N,Bodas S,Veer S,Ghose A,Callan-Jones A,Pullarkat P

更新日期：2020-04-08 00:00:00

abstract：:Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelle...

journal_title：eLife

authors： Banerjee JJ,Aerne BL,Holder MV,Hauri S,Gstaiger M,Tapon N

更新日期：2017-06-30 00:00:00

abstract：:Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR-mediated chloride and bicarbonate transport, with dysregulation of epithelial sodium channels (ENaC). These changes alter fluid and electrolyte homeostasis...

journal_title：eLife

authors： Scambler T,Jarosz-Griffiths HH,Lara-Reyna S,Pathak S,Wong C,Holbrook J,Martinon F,Savic S,Peckham D,McDermott MF

更新日期：2019-09-18 00:00:00

abstract：:The growth of preprints in the life sciences has been reported widely and is driving policy changes for journals and funders, but little quantitative information has been published about preprint usage. Here, we report how we collected and analyzed data on all 37,648 preprints uploaded to bioRxiv.org, the largest biol...

journal_title：eLife

authors： Abdill RJ,Blekhman R

更新日期：2019-04-24 00:00:00

abstract：:Hox genes are essential regulators of embryonic development. Their step-wise transcriptional activation follows their genomic topology and the various states of activation are subsequently memorized into domains of progressively overlapping gene products. We have analyzed the 3D chromatin organization of Hox clusters ...

journal_title：eLife

authors： Noordermeer D,Leleu M,Schorderet P,Joye E,Chabaud F,Duboule D

更新日期：2014-04-29 00:00:00

abstract：:The Maternal Embryonic Leucine Zipper Kinase (MELK) has been identified as a promising therapeutic target in multiple cancer types. MELK over-expression is associated with aggressive disease, and MELK has been implicated in numerous cancer-related processes, including chemotherapy resistance, stem cell renewal, and tu...

journal_title：eLife

authors： Giuliano CJ,Lin A,Smith JC,Palladino AC,Sheltzer JM

更新日期：2018-02-08 00:00:00

abstract：:The prefrontal cortex (PFC)'s functions are thought to include working memory, as its activity can reflect information that must be temporarily maintained to realize the current goal. We designed a flexible spatial working memory task that required rats to navigate - after distractions and a delay - to multiple possib...

journal_title：eLife

authors： Böhm C,Lee AK

更新日期：2020-12-24 00:00:00

abstract：:Although seasonality is widespread and can cause fluctuations in the intensity and direction of natural selection, we have little information about the consequences of seasonal fitness trade-offs for population dynamics. Here we exposed populations of Drosophila melanogaster to repeated seasonal changes in resources a...

journal_title：eLife

authors： Betini GS,McAdam AG,Griswold CK,Norris DR

更新日期：2017-02-06 00:00:00

abstract：:Studies in different animal model systems have revealed the impact of odors on immune cells; however, any understanding on why and how odors control cellular immunity remained unclear. We find that Drosophila employ an olfactory-immune cross-talk to tune a specific cell type, the lamellocytes, from hematopoietic-proge...

journal_title：eLife

authors： Madhwal S,Shin M,Kapoor A,Goyal M,Joshi MK,Ur Rehman PM,Gor K,Shim J,Mukherjee T

更新日期：2020-12-29 00:00:00

abstract：:SUMO1-conjugation of proteins at neuronal synapses is considered to be a major post-translational regulatory process in nerve cell and synapse function, but the published evidence for SUMO1-conjugation at synapses is contradictory. We employed multiple genetic mouse models for stringently controlled biochemical and im...

journal_title：eLife

authors： Daniel JA,Cooper BH,Palvimo JJ,Zhang FP,Brose N,Tirard M

更新日期：2017-06-09 00:00:00

abstract：:During sleep, the brain experiences large fluctuations in blood volume and altered coupling between neural and vascular signals. ...

journal_title：eLife

authors： Williams SD,Lewis LD

更新日期：2020-12-23 00:00:00

abstract：:Negative feedback regulation, that is the ability of a gene to repress its own synthesis, is the most abundant regulatory motif known to biology. Frequently reported for transcriptional regulators, negative feedback control relies on binding of a transcription factor to its own promoter. Here, we report a novel mechan...

journal_title：eLife

authors： Hoyos M,Huber M,Förstner KU,Papenfort K

更新日期：2020-08-03 00:00:00

abstract：:Recent studies suggested an essential role for seryl-tRNA synthetase (SerRS) in vascular development. This role is specific to SerRS among all tRNA synthetases and is independent of its well-known aminoacylation function in protein synthesis. A unique nucleus-directing domain, added at the invertebrate-to-vertebrate t...

journal_title：eLife

authors： Shi Y,Xu X,Zhang Q,Fu G,Mo Z,Wang GS,Kishi S,Yang XL

更新日期：2014-06-17 00:00:00

abstract：:Proprioception, the sense of body position, movement, and associated forces, remains poorly understood, despite its critical role in movement. Most studies of area 2, a proprioceptive area of somatosensory cortex, have simply compared neurons' activities to the movement of the hand through space. Using motion tracking...

journal_title：eLife

authors： Chowdhury RH,Glaser JI,Miller LE

更新日期：2020-01-23 00:00:00

abstract：:Animals and humans replay neural patterns encoding trajectories through their environment, both whilst they solve decision-making tasks and during rest. Both on-task and off-task replay are believed to contribute to flexible decision making, though how their relative contributions differ remains unclear. We investigat...

journal_title：eLife

authors： Eldar E,Lièvre G,Dayan P,Dolan RJ

更新日期：2020-06-17 00:00:00

abstract：:Antiviral effectors such as natural killer (NK) cells have impaired functions in chronic hepatitis B (CHB) patients. The molecular mechanism responsible for this dysfunction remains poorly characterised. We show that decreased cytokine production capacity of peripheral NK cells from CHB patients was associated with re...

journal_title：eLife

authors： Marotel M,Villard M,Drouillard A,Tout I,Besson L,Allatif O,Pujol M,Rocca Y,Ainouze M,Roblot G,Viel S,Gomez M,Loustaud V,Alain S,Durantel D,Walzer T,Hasan U,Marçais A

更新日期：2021-01-28 00:00:00

abstract：:Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses that Prp3 contains a bipartite U4/U6 di-snRNA-binding region comprising an expanded ferredoxin-like fold, which recognizes...

journal_title：eLife

authors： Liu S,Mozaffari-Jovin S,Wollenhaupt J,Santos KF,Theuser M,Dunin-Horkawicz S,Fabrizio P,Bujnicki JM,Lührmann R,Wahl MC

更新日期：2015-07-10 00:00:00

abstract：:Exhaustion of stem cells is a hallmark of aging. In the Drosophila testis, dedifferentiated germline stem cells (GSCs) derived from spermatogonia increase during lifespan, leading to the model that dedifferentiation counteracts the decline of GSCs in aged males. To test this, we blocked dedifferentiation by mis-expres...

journal_title：eLife

authors： Herrera SC,Bach EA

更新日期：2018-07-09 00:00:00

abstract：:Delineating the basic cellular components of cortical inhibitory circuits remains a fundamental issue in order to understand their specific contributions to microcircuit function. It is still unclear how current classifications of cortical interneuron subtypes relate to biological processes such as their developmental...

journal_title：eLife

authors： Niquille M,Limoni G,Markopoulos F,Cadilhac C,Prados J,Holtmaat A,Dayer A

更新日期：2018-03-20 00:00:00

abstract：:Engaging with vocal sounds is critical for children's social-emotional learning, and children with autism spectrum disorder (ASD) often 'tune out' voices in their environment. Little is known regarding the neurobiological basis of voice processing and its link to social impairments in ASD. Here, we perform the first c...

journal_title：eLife

authors： Abrams DA,Padmanabhan A,Chen T,Odriozola P,Baker AE,Kochalka J,Phillips JM,Menon V

更新日期：2019-02-26 00:00:00

abstract：:Examining whether and how the rhythms of limb and breathing movements interact is highly informative about the mechanistic origin of hyperpnoea during running exercise. However, studies have failed to reveal regularities. In particular, whether breathing frequency is inherently proportional to limb velocity and impose...

journal_title：eLife

authors： Hérent C,Diem S,Fortin G,Bouvier J

更新日期：2020-12-01 00:00:00

abstract：:Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS). We hypothesized that TMAO exerts beneficial effects on the circulatory system and pr...

journal_title：eLife

authors： Gawrys-Kopczynska M,Konop M,Maksymiuk K,Kraszewska K,Derzsi L,Sozanski K,Holyst R,Pilz M,Samborowska E,Dobrowolski L,Jaworska K,Mogilnicka I,Ufnal M

更新日期：2020-06-08 00:00:00

abstract：:Responses of sensory neurons represent stimulus information, but are also influenced by internal state. For example, when monkeys direct their attention to a visual stimulus, the response gain of specific subsets of neurons in visual cortex changes. Here, we develop a functional model of population activity to investi...

journal_title：eLife

authors： Rabinowitz NC,Goris RL,Cohen M,Simoncelli EP

更新日期：2015-11-02 00:00:00

abstract：:Aedes aegypti transmit pathogenic arboviruses while the mosquito itself tolerates the infection. We examine a piRNA-based immunity that relies on the acquisition of viral derived cDNA (vDNA) and how this pathway discriminates between self and non-self. The piRNAs derived from these vDNAs are essential for virus contro...

journal_title：eLife

authors： Tassetto M,Kunitomi M,Whitfield ZJ,Dolan PT,Sánchez-Vargas I,Garcia-Knight M,Ribiero I,Chen T,Olson KE,Andino R

更新日期：2019-10-17 00:00:00

abstract：:Intergroup conflict contributes to human discrimination and violence, but persists because individuals make costly contributions to their group's fighting capacity. Yet, how group members effectively coordinate their contributions during intergroup conflict remains poorly understood. Here, we examine the role of oxyto...

journal_title：eLife

authors： Zhang H,Gross J,De Dreu C,Ma Y

更新日期：2019-01-25 00:00:00

abstract：:Postmitotic tissues are incapable of replacing damaged cells through proliferation, but need to rely on buffering mechanisms to prevent tissue disintegration. By constitutively activating the Ras/MAPK-pathway via RasV12-overexpression in the postmitotic salivary glands of Drosophila larvae, we overrode the glands adap...

journal_title：eLife

authors： Krautz R,Khalili D,Theopold U

更新日期：2020-12-30 00:00:00

abstract：:Linking interindividual differences in psychological phenotype to variations in brain structure is an old dream for psychology and a crucial question for cognitive neurosciences. Yet, replicability of the previously-reported 'structural brain behavior' (SBB)-associations has been questioned, recently. Here, we conduct...

journal_title：eLife

authors： Kharabian Masouleh S,Eickhoff SB,Hoffstaedter F,Genon S,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2019-03-13 00:00:00