Area 2 of primary somatosensory cortex encodes kinematics of the whole arm.

abstract：:Unrepaired DNA damage during embryonic development can be potentially inherited by a large population of cells. However, the quality control mechanisms that minimize the contribution of damaged cells to developing embryos remain poorly understood. Here, we uncovered an ATR- and CHK1-mediated transcriptional response t...

journal_title：eLife

authors： Atashpaz S,Samadi Shams S,Gonzalez JM,Sebestyén E,Arghavanifard N,Gnocchi A,Albers E,Minardi S,Faga G,Soffientini P,Allievi E,Cancila V,Bachi A,Fernández-Capetillo Ó,Tripodo C,Ferrari F,López-Contreras AJ,Costanzo V

更新日期：2020-03-12 00:00:00

abstract：:Animals exhibit innate behaviours to a variety of sensory stimuli including olfactory cues. In Drosophila, one higher olfactory centre, the lateral horn (LH), is implicated in innate behaviour. However, our structural and functional understanding of the LH is scant, in large part due to a lack of sparse neurogenetic t...

journal_title：eLife

authors： Dolan MJ,Frechter S,Bates AS,Dan C,Huoviala P,Roberts RJ,Schlegel P,Dhawan S,Tabano R,Dionne H,Christoforou C,Close K,Sutcliffe B,Giuliani B,Li F,Costa M,Ihrke G,Meissner GW,Bock DD,Aso Y,Rubin GM,Jefferis GS

更新日期：2019-05-21 00:00:00

abstract：:Voltage-gated potassium (Kv) channels enable potassium efflux and membrane repolarization in excitable tissues. Many Kv channels undergo a progressive loss of ion conductance in the presence of a prolonged voltage stimulus, termed slow inactivation, but the atomic determinants that regulate the kinetics of this proces...

journal_title：eLife

authors： Pless SA,Galpin JD,Niciforovic AP,Kurata HT,Ahern CA

更新日期：2013-12-10 00:00:00

abstract：:Despite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior-posterior axis. Hox proteins exert their function by interaction wit...

journal_title：eLife

authors： Hudry B,Thomas-Chollier M,Volovik Y,Duffraisse M,Dard A,Frank D,Technau U,Merabet S

更新日期：2014-03-18 00:00:00

abstract：:Congenital diaphragmatic hernia (CDH) is a severe birth defect. Wt1-null mouse embryos develop CDH but the mechanisms regulated by WT1 are unknown. We have generated a murine model with conditional deletion of WT1 in the lateral plate mesoderm, using the G2 enhancer of the Gata4 gene as a driver. 80% of G2-Gata4(Cre);...

journal_title：eLife

authors： Carmona R,Cañete A,Cano E,Ariza L,Rojas A,Muñoz-Chápuli R

更新日期：2016-09-19 00:00:00

abstract：:The speed at which a cell fate decision in nematode worms evolves is due to the number of genes that control the decision, rather than to a high mutation rate. ...

journal_title：eLife

authors： Yang B,Rifkin SA

更新日期：2020-10-14 00:00:00

abstract：:An 'interactome' screen of all Drosophila cell-surface and secreted proteins containing immunoglobulin superfamily (IgSF) domains discovered a network formed by paralogs of Beaten Path (Beat) and Sidestep (Side), a ligand-receptor pair that is central to motor axon guidance. Here we describe a new method for interacto...

journal_title：eLife

authors： Li H,Watson A,Olechwier A,Anaya M,Sorooshyari SK,Harnett DP,Lee HP,Vielmetter J,Fares MA,Garcia KC,Özkan E,Labrador JP,Zinn K

更新日期：2017-08-15 00:00:00

abstract：:Holliday junctions (HJs) are key DNA intermediates in homologous recombination. They link homologous DNA strands and have to be faithfully removed for proper DNA segregation and genome integrity. Here, we present the crystal structure of human HJ resolvase GEN1 complexed with DNA at 3.0 Å resolution. The GEN1 core is ...

journal_title：eLife

authors： Lee SH,Princz LN,Klügel MF,Habermann B,Pfander B,Biertümpfel C

更新日期：2015-12-18 00:00:00

abstract：:Although activation/deactivation of specific brain regions has been shown to be predictive of successful memory encoding, the relationship between time-varying large-scale brain networks and fluctuations of memory encoding performance remains unclear. Here, we investigated time-varying functional connectivity patterns...

journal_title：eLife

authors： Keerativittayayut R,Aoki R,Sarabi MT,Jimura K,Nakahara K

更新日期：2018-06-18 00:00:00

abstract：:Microtubules control different aspects of cell polarization. In cells with a radial microtubule system, a pivotal role in setting up asymmetry is attributed to the relative positioning of the centrosome and the nucleus. Here, we show that centrosome loss had no effect on the ability of endothelial cells to polarize an...

journal_title：eLife

authors： Martin M,Veloso A,Wu J,Katrukha EA,Akhmanova A

更新日期：2018-03-16 00:00:00

abstract：:Numerous links exist between co-transcriptional RNA processing and the transcribing RNAPII. In particular, pre-mRNA splicing was reported to be associated with slowed RNAPII elongation. Here, we identify a site of ubiquitination (K1246) in the catalytic subunit of RNAPII close to the DNA entry path. Ubiquitination was...

journal_title：eLife

authors： Milligan L,Sayou C,Tuck A,Auchynnikava T,Reid JE,Alexander R,Alves FL,Allshire R,Spanos C,Rappsilber J,Beggs JD,Kudla G,Tollervey D

更新日期：2017-10-13 00:00:00

abstract：:Dietary magnesium (Mg2+) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg2+ feeding also enhances long-term memory ...

journal_title：eLife

authors： Wu Y,Funato Y,Meschi E,Jovanoski KD,Miki H,Waddell S

更新日期：2020-11-26 00:00:00

abstract：:Genome-wide association analyses have uncovered multiple genomic regions associated with T2D, but identification of the causal variants at these remains a challenge. There is growing interest in the potential of deep learning models - which predict epigenome features from DNA sequence - to support inference concerning...

journal_title：eLife

authors： Wesolowska-Andersen A,Zhuo Yu G,Nylander V,Abaitua F,Thurner M,Torres JM,Mahajan A,Gloyn AL,McCarthy MI

更新日期：2020-01-27 00:00:00

abstract：:To efficiently navigate through the environment and avoid potential threats, an animal must quickly detect the motion of approaching objects. Current models of primate vision place the origins of this complex computation in the visual cortex. Here, we report that detection of approaching motion begins in the retina. S...

journal_title：eLife

authors： Appleby TR,Manookin MB

更新日期：2020-02-24 00:00:00

abstract：:Neurotransmitter release requires formation of trans-SNARE complexes between the synaptic vesicle and plasma membranes, which likely underlies synaptic vesicle priming to a release-ready state. It is unknown whether Munc18-1, Munc13-1, complexin-1 and synaptotagmin-1 are important for priming because they mediate tran...

journal_title：eLife

authors： Prinslow EA,Stepien KP,Pan YZ,Xu J,Rizo J

更新日期：2019-01-18 00:00:00

abstract：:Many species, including rats, are sensitive to social signals and their valuation is important in social learning. Here we introduce a task that investigates if mutual reward delivery in male rats can drive associative learning. We found that when actor rats have fully learned a stimulus-self-reward association, addin...

journal_title：eLife

authors： van Gurp S,Hoog J,Kalenscher T,van Wingerden M

更新日期：2020-10-01 00:00:00

abstract：:Cells use molecular circuits to interpret and respond to extracellular cues, such as hormones and cytokines, which are often released in a temporally varying fashion. In this study, we combine microfluidics, time-lapse microscopy, and computational modeling to investigate how the type I interferon (IFN)-responsive reg...

journal_title：eLife

authors： Mudla A,Jiang Y,Arimoto KI,Xu B,Rajesh A,Ryan AP,Wang W,Daugherty MD,Zhang DE,Hao N

更新日期：2020-09-18 00:00:00

abstract：:Mitochondrial dysfunction is associated with activation of the integrated stress response (ISR) but the underlying triggers remain unclear. We systematically combined acute mitochondrial inhibitors with genetic tools for compartment-specific NADH oxidation to trace mechanisms linking different forms of mitochondrial d...

journal_title：eLife

authors： Mick E,Titov DV,Skinner OS,Sharma R,Jourdain AA,Mootha VK

更新日期：2020-05-28 00:00:00

abstract：:Aging is an intricate phenomenon associated with the gradual loss of physiological functions, and both nutrient sensing and proteostasis control lifespan. Although multiple approaches have facilitated the identification of candidate genes that govern longevity, the molecular mechanisms that link aging pathways are sti...

journal_title：eLife

authors： Chen YC,Jiang PH,Chen HM,Chen CH,Wang YT,Chen YJ,Yu CJ,Teng SC

更新日期：2018-12-05 00:00:00

abstract：:Drug treatment of 3D cancer spheroids more accurately reflects in vivo therapeutic responses compared to adherent culture studies. In EGFR-mutated lung adenocarcinoma, EGFR-TKIs show enhanced efficacy in spheroid cultures. Simultaneous inhibition of multiple parallel RTKs further enhances EGFR-TKI effectiveness. We sh...

journal_title：eLife

authors： Theard PL,Sheffels E,Sealover NE,Linke AJ,Pratico DJ,Kortum RL

更新日期：2020-09-08 00:00:00

abstract：:Organisms possessing genetic codes with unassigned codons raise the question of how cellular machinery resolves such codons and how this could impact horizontal gene transfer. Here, we use a genomically recoded Escherichia coli to examine how organisms address translation at unassigned UAG codons, which obstruct propa...

journal_title：eLife

authors： Ma NJ,Hemez CF,Barber KW,Rinehart J,Isaacs FJ

更新日期：2018-10-30 00:00:00

abstract：:Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson's disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin ligase Parkin is important to trigger selective autophagy. Although autop...

journal_title：eLife

authors： Yamano K,Wang C,Sarraf SA,Münch C,Kikuchi R,Noda NN,Hizukuri Y,Kanemaki MT,Harper W,Tanaka K,Matsuda N,Youle RJ

更新日期：2018-01-23 00:00:00

abstract：:Burkholderia thailandensis uses acyl-homoserine lactone-mediated quorum sensing systems to regulate hundreds of genes. Here we show that cell-cell contact-dependent type VI secretion (T6S) toxin-immunity systems are among those activated by quorum sensing in B. thailandensis. We also demonstrate that T6S is required t...

journal_title：eLife

authors： Majerczyk C,Schneider E,Greenberg EP

更新日期：2016-05-16 00:00:00

abstract：:Improving the peer review process, overcoming the limitations of print journals and providing open access to the very best work in the life and biomedical sciences are three highlights of our first year. ...

journal_title：eLife

authors： Schekman R,Watt FM,Weigel D

更新日期：2013-10-15 00:00:00

abstract：:Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks. We found that activating dorsal raphe nucleus (DRN) 5-HT neurons induced a stro...

journal_title：eLife

authors： Correia PA,Lottem E,Banerjee D,Machado AS,Carey MR,Mainen ZF

更新日期：2017-02-14 00:00:00

abstract：:Two gene variants provide different levels of protection against sleeping sickness, but this comes with an increased risk of developing chronic kidney disease. ...

journal_title：eLife

authors： Kruzel-Davila E,Skorecki K

更新日期：2017-07-03 00:00:00

abstract：:Interactions between membrane protein interfaces in lipid bilayers play an important role in membrane protein folding but quantification of the strength of these interactions has been challenging. Studying dimerization of ClC-type transporters offers a new approach to the problem, as individual subunits adopt a stable...

journal_title：eLife

authors： Chadda R,Krishnamani V,Mersch K,Wong J,Brimberry M,Chadda A,Kolmakova-Partensky L,Friedman LJ,Gelles J,Robertson JL

更新日期：2016-08-03 00:00:00

abstract：:Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the molecular and cellular mechanisms underpinning these ageing processes re...

journal_title：eLife

authors： Baran-Gale J,Morgan MD,Maio S,Dhalla F,Calvo-Asensio I,Deadman ME,Handel AE,Maynard A,Chen S,Green F,Sit RV,Neff NF,Darmanis S,Tan W,May AP,Marioni JC,Ponting CP,Holländer GA

更新日期：2020-08-25 00:00:00

abstract：:Optogenetic approaches are leading to a better understanding of the forces that determine the plane of cell division. ...

journal_title：eLife

authors： Serra-Marques A,Dumont S

更新日期：2018-07-09 00:00:00

abstract：:Understanding how genes and experience work in concert to generate phenotypic variability will provide a better understanding of individuality. Here, we considered this in the main olfactory epithelium, a chemosensory structure with over a thousand distinct cell types in mice. We identified a subpopulation of olfactor...

journal_title：eLife

authors： Vihani A,Hu XS,Gundala S,Koyama S,Block E,Matsunami H

更新日期：2020-11-24 00:00:00